Enhanced efficacy of transforming growth factor-β1 loaded an injectable cross-linked thiolated chitosan and carboxymethyl cellulose-based hydrogels for cartilage tissue engineering

Zhang, Zefeng; Lin, Shufeng; Yan, Yipeng; You, Xiaoxuan; Ye, Hui

doi:10.1080/09205063.2021.1971823

Cited by 14 publications

(6 citation statements)

References 60 publications

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“…In their study, Cui and colleagues fabricated a sustained release platform of anhydroicaritin from chitosan hydrogel and mesoporous SiO 2 nanoparticles, which would lead to chondrogenesis of articular cartilage stem cells, promotion of ECM formation, and consequent in vivo cartilage regeneration [ 66 ]. Zhang and colleagues investigated the efficiency of transforming growth factor-β1 (TGF-β1) alone or in cross-linked thiolated chitosan and carboxymethyl cellulose hydrogel [ 67 ]. As a result of their study, it was reported that TGF-β1-loaded hydrogels had a higher curative performance as cells within regenerated cartilage tissue and acquired uniform morphology and the ability to produce ECM components and were distributed throughout the scaffold [ 67 ].…”

Section: Bone Cartilage and Dental Tissuesmentioning

confidence: 99%

Chitosan-Based Biomaterials for Tissue Regeneration

et al. 2023

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Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It has numerous qualities that make it attractive for biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, and many others. Importantly, chitosan can be fabricated into a variety of structures including nanoparticles, scaffolds, hydrogels, and membranes, which can be tailored to deliver a desirable outcome. Composite chitosan-based biomaterials have been demonstrated to stimulate in vivo regeneration and the repair of various tissues and organs, including but not limited to, bone, cartilage, dental, skin, nerve, cardiac, and other tissues. Specifically, de novo tissue formation, resident stem cell differentiation, and extracellular matrix reconstruction were observed in multiple preclinical models of different tissue injuries upon treatment with chitosan-based formulations. Moreover, chitosan structures have been proven to be efficient carriers for medications, genes, and bioactive compounds since they can maintain the sustained release of these therapeutics. In this review, we discuss the most recently published applications of chitosan-based biomaterials for different tissue and organ regeneration as well as the delivery of various therapeutics.

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Section: Bone Cartilage and Dental Tissuesmentioning

confidence: 99%

Chitosan-Based Biomaterials for Tissue Regeneration

et al. 2023

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“…The physical capabilities of cellulose depend on the presence of three hydroxyl groups (OH) at the C-6, C-3, and C-2 positions. Cellulose injectable hydrogels made from carboxymethyl cellulose (CMC), methylcellulose (MC), and hydroxypropyl cellulose (HPC) have good mechanical properties and are biocompatible ( Zhang et al, 2021b ).…”

Section: Materials Of Injectable Hydrogelsmentioning

confidence: 99%

“…TGF-β1 is abundant in natural cartilage and controls cartilage ECM production by affecting the synthesis of fibronectin, proteoglycan, and collagen ( Zheng et al, 2022 ). Zhang et al 2(2021b) developed an injectable hydrogel system based on cross-linked thiolated chitosan and carboxymethyl cellulose as carriers for TGF-β1 in cartilage tissue engineering applications. At 8 weeks postoperatively, hydrogels loaded with TGF-β1 showed excellent repairability in a rat model of full-thickness cartilage defects of the knee.…”

Section: Materials Of Injectable Hydrogelsmentioning

confidence: 99%

Advanced injectable hydrogels for cartilage tissue engineering

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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The rapid development of tissue engineering makes it an effective strategy for repairing cartilage defects. The significant advantages of injectable hydrogels for cartilage injury include the properties of natural extracellular matrix (ECM), good biocompatibility, and strong plasticity to adapt to irregular cartilage defect surfaces. These inherent properties make injectable hydrogels a promising tool for cartilage tissue engineering. This paper reviews the research progress on advanced injectable hydrogels. The cross-linking method and structure of injectable hydrogels are thoroughly discussed. Furthermore, polymers, cells, and stimulators commonly used in the preparation of injectable hydrogels are thoroughly reviewed. Finally, we summarize the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.

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“…In addition, chitosan has also been used for the development of systems that load bioactive molecules, such as growth factors (for example, transforming growth factor-β1 [131,132]) and stem cells (such as synovial mesenchymal [133] or adipose-derived stem cells [134]) for cartilage regeneration.…”

Section: Cartilage Regeneration and Viscosupplementationmentioning

confidence: 99%

Applications of Chitosan in Surgical and Post-Surgical Materials

et al. 2022

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The continuous advances in surgical procedures require continuous research regarding materials with surgical applications. Biopolymers are widely studied since they usually provide a biocompatible, biodegradable, and non-toxic material. Among them, chitosan is a promising material for the development of formulations and devices with surgical applications due to its intrinsic bacteriostatic, fungistatic, hemostatic, and analgesic properties. A wide range of products has been manufactured with this polymer, including scaffolds, sponges, hydrogels, meshes, membranes, sutures, fibers, and nanoparticles. The growing interest of researchers in the use of chitosan-based materials for tissue regeneration is obvious due to extensive research in the application of chitosan for the regeneration of bone, nervous tissue, cartilage, and soft tissues. Chitosan can serve as a substance for the administration of cell-growth promoters, as well as a support for cellular growth. Another interesting application of chitosan is hemostasis control, with remarkable results in studies comparing the use of chitosan-based dressings with traditional cotton gauzes. In addition, chitosan-based or chitosan-coated surgical materials provide the formulation with antimicrobial activity that has been highly appreciated not only in dressings but also for surgical sutures or meshes.

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Enhanced efficacy of transforming growth factor-β1 loaded an injectable cross-linked thiolated chitosan and carboxymethyl cellulose-based hydrogels for cartilage tissue engineering

Cited by 14 publications

References 60 publications

Chitosan-Based Biomaterials for Tissue Regeneration

Chitosan-Based Biomaterials for Tissue Regeneration

Advanced injectable hydrogels for cartilage tissue engineering

Applications of Chitosan in Surgical and Post-Surgical Materials

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