Enhanced efficiency of calcium-derived oleoyl serine on osteoporosis via Wnt/β-catenin pathway

Chen, Yujiong; Ke, Chunhai; Zhong, Jiaqi; Cao, Wen‐Qiang; Hu, Xiaodong; Hao, Mingming; Dong, Jieyang; Zhang, Zhewei; Weng, Hangbin; Liu, Botao; Jin, Chunhua; Peng, Zhaoxiang

doi:10.1016/j.biopha.2023.114326

Cited by 2 publications

(1 citation statement)

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“…Osx gene expression is promoted to initiate target gene transcription, promote osteoblast differentiation and proliferation and exert its effects. This is the classic Wnt/β-catenin signalling pathway [36,37].…”

Section: Discussionmentioning

confidence: 99%

Bone protection mechanism of Zuogui Pill in an osteoporosis model of breast cancer rats after endocrine therapy

ao,

Chunhui,

Lei

et al. 2023

Preprint

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Background Postmenopausal breast cancer patients treated with aromatase inhibitors (AIs) have an increased risk of developing secondary osteoporosis. Zuogui Pill has been proven to have obvious preventative and therapeutic effects against osteoporosis in the clinic. However, the possible mechanism of this bone-protective mechanism of Zuogui Pill is still largely unknown.Methods An osteoporosis model of postmenopausal breast cancer was generated by gavage of letrozole in ovariectomized mice with breast cancer. Serum oestradiol (E2), bone alkaline phosphatase (BALP), and amino terminal propeptide of type Ⅰ collagen (PINP) were detected by enzyme-related immunosorbent assays (ELISAs). After death, the right femur and tibia were taken and stained with HE to observe the bone histopathology. Microcomputed tomography (µCT) was used to detect bone density and trabecular microstructure in vitro. The protein expression levels of Wnt3a, β-catenin and Runx2 in bone tissue were detected by Western blots.Results Zuogui Pill significantly decreased the serum level of bone alkaline phosphatase (BALP) and the level of amino terminal procollagen Ⅰ propeptide (PINP) but had no significant effect on oestradiol (E2). Zuogui Pill improved bone tissue morphology, bone microstructure and bone mineral density. The protein expression levels of Wnt3a, β-catenin and Runx2 in the Zuogui Pill groups were significantly increased.Conclusion Zuogui Pill exerts a bone-protective effect through the Wnt/β-catenin and Wnt/Runx2 pathways and has good application value for the treatment of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Bone protection mechanism of Zuogui Pill in an osteoporosis model of breast cancer rats after endocrine therapy

ao,

Chunhui,

Lei

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Advanced Hybrid Strategies of GelMA Composite Hydrogels in Bone Defect Repair

Yu,

Luo,

et al. 2024

Polymers

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To date, severe bone defects remain a significant challenge to the quality of life. All clinically used bone grafts have their limitations. Bone tissue engineering offers the promise of novel bone graft substitutes. Various biomaterial scaffolds are fabricated by mimicking the natural bone structure, mechanical properties, and biological properties. Among them, gelatin methacryloyl (GelMA), as a modified natural biomaterial, possesses a controllable chemical network, high cellular stability and viability, good biocompatibility and degradability, and holds the prospect of a wide range of applications. However, because they are hindered by their mechanical properties, degradation rate, and lack of osteogenic activity, GelMA hydrogels need to be combined with other materials to improve the properties of the composites and endow them with the ability for osteogenesis, vascularization, and neurogenesis. In this paper, we systematically review and summarize the research progress of GelMA composite hydrogel scaffolds in the field of bone defect repair, and discuss ways to improve the properties, which will provide ideas for the design and application of bionic bone substitutes.

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Enhanced efficiency of calcium-derived oleoyl serine on osteoporosis via Wnt/β-catenin pathway

Cited by 2 publications

References 29 publications

Bone protection mechanism of Zuogui Pill in an osteoporosis model of breast cancer rats after endocrine therapy

Bone protection mechanism of Zuogui Pill in an osteoporosis model of breast cancer rats after endocrine therapy

Advanced Hybrid Strategies of GelMA Composite Hydrogels in Bone Defect Repair

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