Enhanced Electrochemiluminescence Employed for the Selective Detection of Methyl Parathion Based on a Zirconia Nanoparticle Film Modified Electrode

Zhou, Heng; Gan, Ning; Hou, J. G.; Li, Tianhua; Cao, Yuting

doi:10.2116/analsci.28.267

Cited by 11 publications

(7 citation statements)

References 51 publications

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“…ECL investigation and determination of GSK-3β were performed using the lab-built quartz ECL cell containing the prepared sensor, Pt wire, Ag wire as the working, counter, and reference electrodes, respectively. , The ECL emission of luminol was generated when an impulse voltage was applied to the working electrode, then recorded after being converted to an electrical signal by the photomultiplier tube . Afterward, 30 μL of H-buffer containing GSK-3β was spread onto the surface of sensor and allowed to equilibrate for 4 h at 35 °C to ensure complete reaction, then rinsed and dried.…”

Section: Methodsmentioning

confidence: 99%

Clinical Chemistry Route for Investigation of Alzheimer’s Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta

Tan

2019

ACS Chem. Neurosci.

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Herein, we report a novel label-free electrochemiluminescent (ECL) biosensor for the detection of glycogen synthase kinase-3 beta (GSK-3β). A simple and feasible sensor was prepared by a two-step process. A polymeric coordination layer of phosphorylated poly vinyl with Zr 4+ was used as the sensory hosting matrix because it efficiently formed a complex. The exterior Zr 4+ can further combine with another phosphate through coordination, and GSK-3β catalyzes the phosphorylation of protein molecules. Thus, the biosensor can detect GSK-3β using luminol as an ECL probe. The ECL intensity of the proposed sensor responded proportionally to the concentration of GSK-3β under direct immersion mode with a linear response in a logarithmic scale over the wide range from 0.5 to 91.5 ng L −1 and a detection limit of 0.055 ng L −1 . Excellent selectivity, stability, and reproducibility were achieved using the prepared biosensor, which has a simple preparation, low cost, and disposable suitability. This work aims to provide a novel tool for early diagnosis and pathological mechanism exploration about AD by detecting inchoate change of GSK-3β content in body fluid, thus to precaution the risk of Alzheimer's disease. It is of great importance for clinical chemistry for the investigation of Alzheimer's disease.

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Section: Methodsmentioning

confidence: 99%

Clinical Chemistry Route for Investigation of Alzheimer’s Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta

Tan

2019

ACS Chem. Neurosci.

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“…Based on this, Lin's group [ 23 ] prepared an electrochemical sensor utilizing ZrO 2 as an OPs selective adsorbent for trace detection of methyl parathion. Cao et al [ 24 ] proposed an electrochemiluminescence (ECL) sensor for direct measurements of OPs pesticides based on the strong affinity of a nano ZrO 2 modified film on the electrode to the phosphoric group.…”

Section: Introductionmentioning

confidence: 99%

“…Cao et al [24] proposed an electrochemiluminescence (ECL) sensor for direct measurements of OPs pesticides based on the strong affinity of a nano ZrO 2 modified film on the electrode to the phosphoric group.…”

mentioning

confidence: 99%

Au@ZrO₂ core‐shell nanoparticles as a surface‐enhanced Raman scattering substrate for organophosphorus compounds detection

Wen

Zhang

et al. 2022

J Raman Spectroscopy

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Organophosphorus (OPs) compounds have received enormous attention due to high neurotoxicity. However, the complex detection environment makes it very difficult to detect the OPs compounds at extremely low‐concentration. Therefore, it is vital to develop a high sensitive analytical method for the detection of low‐concentration OPs compounds at complex environment. Here, we proposed a novel surface‐enhanced Raman scattering (SERS) substrate based on the core‐shell structure Au@ZrO2 for the detection of extremely low‐concentration OPs compounds. By using above SERS substrate, we tested different kinds of OPs compounds and obtained excellent detection results. The detection limit of methyl parathion and triazophos can reach 0.01 mg/kg. Meanwhile, under the actual system (orange peel), the detection limit of the methyl parathion and triazophos also can reach 0.5 and 0.1 mg/kg, respectively. In addition, the above substrate is also very effective for the detection of dimethyl methylphosphonate (DMMP), a simulant for the chemical warfare agent (sarin), and the detection limit can reach 100 mg/kg. Besides, we also verified the reproducibility and stability of Au@ZrO2, which showed excellent properties. The relative standard deviation (RSD) of the SERS signal intensity for 20 tests was 6.38% and the enhancement ability of Au@ZrO2 can remain stable within 30 days. These results show that the proposed Au@ZrO2 SERS substrate has great potential in the detection of OPs compounds at extremely low‐concentration in the complex detection environment.

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“…1), is typical OPPs and most extensively used in agriculture due to its insecticidal properties, and its residues display low toxicity to human health when absorbed by the human body [10,11]. High consumption of malathion and its durability compared with other pesticides (e.g., organochlorines) have been linked to its lower potency [12][13][14]. Malathion and its commercial formulations could adversely affect the immune and central nervous systems, liver, blood, and adrenal glands [15,16].…”

Section: Introductionmentioning

confidence: 99%

A Highly Sensitive Electrochemical Sensor Based on Electrocatalytic Reduction Effect of Cu2+ on Trace Determination of Malathion in Soil and Other Complex Matrices

Alshareef

Orif

Al-Harbi

et al. 2021

International Journal of Electrochemistry

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The current strategy reports a highly sensitive and selective square wave-cathodic stripping voltammetric protocol for malathion determination. The established method was based on the controlled adsorptive accumulation of malathion in the presence of Cu2+ ions in an aqueous solution of pH 2 onto the hanging mercury dropping electrode (HMDE) and measuring the resulting cathodic peak current of the adsorbed species at −0.42 V versus Ag/AgCl electrode. The low limits of detection (LOD) and quantification (LOQ) of malathion of the assay were estimated to be 3.1 × 10−10 and 1.03 × 10−9 M with a linear dynamic range of 1.03×10−9 – 2.0 × 10−7 M, respectively. The method was satisfactorily applied and validated for malathion determination in environmental samples. The experimental Student texp and Fexp values did not exceed the tabulated ttab (2.78) and Ftab (6.39) at 95% (P = 0.05) confidence (n = 5), confirming the precision and independence on the matrix. The developed sensing platform for the detection of malathion shows superior performance to conventional electrochemical methods. The proposed sensor offered simple, economical, reproducible, and applicable approach for the determination of malathion in environmental samples.

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Enhanced Electrochemiluminescence Employed for the Selective Detection of Methyl Parathion Based on a Zirconia Nanoparticle Film Modified Electrode

Cited by 11 publications

References 51 publications

Clinical Chemistry Route for Investigation of Alzheimer’s Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta

Clinical Chemistry Route for Investigation of Alzheimer’s Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta

Au@ZrO₂ core‐shell nanoparticles as a surface‐enhanced Raman scattering substrate for organophosphorus compounds detection

A Highly Sensitive Electrochemical Sensor Based on Electrocatalytic Reduction Effect of Cu2+ on Trace Determination of Malathion in Soil and Other Complex Matrices

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Enhanced Electrochemiluminescence Employed for the Selective Detection of Methyl Parathion Based on a Zirconia Nanoparticle Film Modified Electrode

Cited by 11 publications

References 51 publications

Clinical Chemistry Route for Investigation of Alzheimer’s Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta

Clinical Chemistry Route for Investigation of Alzheimer’s Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta

Au@ZrO2 core‐shell nanoparticles as a surface‐enhanced Raman scattering substrate for organophosphorus compounds detection

A Highly Sensitive Electrochemical Sensor Based on Electrocatalytic Reduction Effect of Cu2+ on Trace Determination of Malathion in Soil and Other Complex Matrices

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Au@ZrO₂ core‐shell nanoparticles as a surface‐enhanced Raman scattering substrate for organophosphorus compounds detection