Enhanced enteric properties and stability of shellac films through composite salts formation

Limmatvapirat, Sontaya; Limmatvapirat, Chutima; Puttipipatkhachorn, Satit; Nuntanid, Jurairat; Luangtana‐anan, Manee

doi:10.1016/j.ejpb.2007.04.008

Cited by 119 publications

(83 citation statements)

References 11 publications

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“…These results were in agreement with the results of investigation of solubility and swelling rate of 100% [w/w] shellac films (insolubility and the low swelling rate at pH 1.2 as well as the low solubility at pH 6.8, see Figs. 1 and 3), and also in agreement with the results of other investigators (Limmatvapirat et al, 2004(Limmatvapirat et al, , 2007Pearnchob, Dashevsky, & Bodmeier, 2004).…”

Section: Discussionsupporting

confidence: 93%

“…In general, shellac possesses good resistance to gastric fluid, suggesting its use for enteric coating purposes. However, the low solubility of shellac in the intestinal fluid, especially in the case of enteric coating of hydrophobic substances limits its use as an enteric coating polymer (Limmatvapirat et al, 2004;Limmatvapirat, Limmatvapirat, Puttipipatkhachorn, Nuntanid, & Luangtana-anan, 2007;McGuire & Hagenmaier, 1996;Pearnchob, Dashevsky, & Bodmeier, 2004;Pearnchob, Dashevsky, Siepmann, & Bodmeier, 2003;Qussi & Suess, 2005).…”

Section: Introductionmentioning

confidence: 98%

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Application of shellac for the development of probiotic formulations

Stummer

Salar-Behzadi

Unger

et al. 2010

Food Research International

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Application of shellac for the development of probiotic formulations

Stummer

Salar-Behzadi

Unger

et al. 2010

Food Research International

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“…The probe moved down at 1 mm s −1 and during the test the velocity was kept constant (0.1 mm s −1 ). The trigger force was 0.005 kg and the force versus displacement curves were recorded until the film rupture and used to determine the puncture strength (P s ), elongation at break (E b ) and perforation energy (E p ) parameters according equations below (Limmatvapirat, Limmatvapirat, Puttipipatkhachorn, Nuntanid, & Luangtana-Anan, 2007;Muschert et al, 2009;Sungthongjeen, Puttipipatkhachorn, Paeratakul, Dashevsky, & Bodmeier, 2004):…”

Section: Mechanical Properties Of Free Filmsmentioning

confidence: 99%

Films from resistant starch-pectin dispersions intended for colonic drug delivery

Meneguin

Cury

Evangelista

2014

Carbohydrate Polymers

107

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Free films were obtained by the solvent casting method from retrograded starch-pectin dispersions at different polymer proportions and concentrations with and without plasticizer. Film forming dispersions were characterized according to their hardness, birefringence and rheological properties. The polymer dispersions showed a predominantly viscous behavior (G″>G') and the absence of plasticizers lead to building of stronger structures, while the occurrence of Maltese crosses in the retrograded dispersions indicates the occurrence of a crystalline organization. Analyses of the films included mechanical properties, thickness, superficial and cross sectional morphology, water vapor permeability, liquid uptake ability, X-ray diffractometry, in vitro dissolution and enzymatic digestion. The high resistant starch content (65.8-96.8%) assured the resistance of materials against enzymatic digestion by pancreatin. Changes in the X-ray diffraction patterns indicated a more organized and crystalline structure of free films in relation to isolated polymers. Increasing of pectin proportion and pH values favored the dissolution and liquid uptake of films. Films prepared with lower polymer concentration presented better barrier function (WVP and mechanical properties).

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“…This can have consequences for shellac-coated dosage forms. Due to the already poor water solubility of shellac and its comparatively high dissolution pH of about 7.3 (14), a further reduction in the solubility might lead to incomplete drug release. On the other hand, acid-labile drug substances could be degraded because of an increased permeability to gastric fluid caused by the loss of gastric resistance.…”

Section: Figure 2 Correlation Of Acid Values and Glass Transition Tementioning

confidence: 99%

Physicochemical Properties of Various Shellac Types

Farag¹,

Leopold

2009

Dissolution Technol.

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Shellac in its acid form undergoes aging, resulting in the change of its physicochemical properties. Therefore, various shellac types were investigated as free films prepared from ammoniacal solutions and as micronized powder in its acid form. Due to its acidic character, shellac shows a pH-dependent solubility. The dissolution properties of shellac films prepared from ammoniacal solution were investigated at various pH values using a dissolution apparatus with basket holder. Micronized shellac in its acid form was analyzed using the intrinsic dissolution method (Ph. Eur.) with a paddleover-disk apparatus. The dissolution properties of the investigated shellac types were correlated with their acid values and their thermal properties. Aging of shellac results in an increase in the glass transition temperature and a decrease in the acid value and the solubility. However, the extent of this change in physicochemical properties depends on the type of shellac, its origin, and type of refining process. Besides the acid value and the glass transition temperature, the intrinsic dissolution rate is an important parameter for the characterization of different shellac types.

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Enhanced enteric properties and stability of shellac films through composite salts formation

Cited by 119 publications

References 11 publications

Application of shellac for the development of probiotic formulations

Application of shellac for the development of probiotic formulations

Films from resistant starch-pectin dispersions intended for colonic drug delivery

Physicochemical Properties of Various Shellac Types

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