2016
DOI: 10.1159/000445655
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Enhanced Eryptosis Following Exposure to Dolutegravir

Abstract: Background/Aims: The viral integrase enzyme inhibitor dolutegravir is utilized for the treatment of immunodeficiency virus (HIV) infection. Knowledge on cytotoxicity of dolutegravir is limited. The present study thus explored, whether dolutegravir is able to trigger suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Cellular mechanisms involved in the triggering of eryptosis include inc… Show more

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Cited by 41 publications
(23 citation statements)
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“…In SLE patients, however, the anemia prevails despite the increased reticulocyte count, implying that anemia is not the result of the reduced formation of erythrocytes but rather a consequence of enhanced eryptosis. Simultaneously, a significant decrease in average cell volume in fresh erythrocyte from SLE patients could be observed, which is another characteristic of eryptosis [14].…”
Section: Discussionmentioning
confidence: 84%
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“…In SLE patients, however, the anemia prevails despite the increased reticulocyte count, implying that anemia is not the result of the reduced formation of erythrocytes but rather a consequence of enhanced eryptosis. Simultaneously, a significant decrease in average cell volume in fresh erythrocyte from SLE patients could be observed, which is another characteristic of eryptosis [14].…”
Section: Discussionmentioning
confidence: 84%
“…Signaling involved in the triggering of eryptosis further includes oxidative stress [18], ceramide [19], hyperosmotic shock [20], energy deficiency [21], caspase activation [22] and deranged activity of several kinases such as CK1α, PKC, AMPK, GK, PAK2, JAK3, p38-MAPK [14,17,19,[23][24][25].…”
Section: +mentioning
confidence: 99%
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“…Многочисленными исследованиями установлено, что эриптоз запускается прежде всего повышением внутриклеточной концентрации свободных ионов кальция, а также рядом веществ эндогенного и экзо генного происхождения: металлами и их соединениями, лекарственными препаратами и ксенобиотиками [26,27,51,90,91,267,268]. Воздействие этих веществ либо запускает механизмы, связанные с повышением внутриклеточной концентрации свободных ионов кальция и усилением выработки эндогенного церамида, либо активирует дополнительные механизмы, такие как энергетическое истощение по АТФ, окислительный стресс и/или активация каспазы 3.…”
Section: молекулярные механизмы процесса эриптозаunclassified
“…Erythrocytes from newborns are highly sensitive to oxidative stress leading to rapid eryptosis and subsequent clearance of those erythrocytes following birth . Eryptosis is triggered by complement, hyperosmotic shock, energy depletion, oxidative stress, cellular K + loss, hyperthermia and a wide variety of xenobiotics including diverse cytostatic drugs (see below).…”
Section: Introductionmentioning
confidence: 99%