Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology

Attari, Zenab; Bhandari, Amita; Jagadish, P C; Lewis, Shaila

doi:10.1016/j.jsps.2015.03.008

Cited by 56 publications

(29 citation statements)

References 18 publications

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“…Pneumothorax then occur after bullae rupture. Many scholars hold based on research that the mechanism described above belong to one-way valve mechanism; third, for a small number of patients, lung tumor tissue and visceral pleura can have direct invasion (ATTARI et al, 2016;ABDEL et al, 2016). In this study, there were 1900 patients having lung cancer with distal visceral pleura rupture.…”

Section: Discussionmentioning

confidence: 85%

Application of VATS in Diagnosis and Treatment of Lung Cancer Complicated with Pneumothorax

Lv¹,

Zhao²,

Zhang³

et al. 2018

Biosci. J.

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ABSTRACT:The paper aims to explore clinical symptoms and complication characteristic of lung cancer complicated with pneumothorax, analyze clinical diagnostic value of VATS, and elaborate on specific clinical programs and significance. To investigate diagnosis and therapeutic value of VATS for lung cancer complicated with pneumothorax, 1900 cases of patients with lung cancer complicated with pneumothorax were randomly selected as research objects to be treated with VATS, and then analysis of their clinical data was done. The clinical data showed that many patients were not clearly diagnosed before operation. In VATS operation, lung tumor tissue was removed and then immediately frozen and sliced. Appropriate surgical approach was chosen based on specific circumstances of patients. As can be known from the results, 1000 cases were treated with wedge resection of lung tumor under thoracoscopy, 900 cases were treated with assisted small incision surgery under thoracoscopy. 1400 cases of lung metastasis were treated with pleural friction fixation. All the operations were successful, with pathology being clearly diagnosed. After surgery, 8 patients had mild air leakage, which could be heal without special treatment. There was no perioperative death. The above analysis shows that VATS can clearly diagnose peripheral lung tumor, and fundamentally cure pneumothorax and lung cancer, which is thus recommended in clinic.

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Section: Discussionmentioning

confidence: 85%

Application of VATS in Diagnosis and Treatment of Lung Cancer Complicated with Pneumothorax

Lv¹,

Zhao²,

Zhang³

et al. 2018

Biosci. J.

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“…The ex-vivo permeation study of DE-NLCs was carried out using non-averted gut sac method with modification (21,22) , male SD rats, weighing approximately 250-300 g, were fasted overnight with free access to water, anesthetized with ether and a longitudinal abdominal incision was made then the small intestine was removed and the mesentery was stripped manually and washed out carefully with cold normal saline solution using a syringe equipped with blunt end needle. The clean intestine was cut into 10 ± 0.2 cm long sacs having a diameter of 0.25mm.…”

Section: Ex-vivo Intestinal Permeation Studymentioning

confidence: 99%

Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model

Abed

Hussein²

2019

IJPS

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Abstract The purpose of our study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DE-NLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral absorption of low bioavailability drug, different Oleic acid ratios effect on particle size, zeta potential, entrapment efficiency and loading capacity were studied, the optimized DE-NLCs shows a particle size within the nanorange, the zeta potential (ZP) was 33.81±0.73mV with drug entrapment efficiency (EE%) of 92.42±2.31% and a loading capacity (DL%) of 7.69±0.17%. about 92% of drug was released in 24hr in a controlled manner, the ex-vivo intestinal permeation study using the non-everted sac model shows four folds increment in the permeation of DE-NLCs compared to dabigatran etexilate suspension (DE-S).

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“…by precipitation (Du et al, 2015), solvent evaporation (Jallouli et al, 2015) or emulsion congealing (Hassan et al, 1995;Matos-Jr et al, 2015) or by a top-down approach from pre-existing solid particles (e.g. by wet milling (Afolabi et al, 2014;Li et al, 2015), high-pressure homogenisation (Möschwitzer, 2013;Tuomela et al, 2016) or their combination (Attari et al, 2016;Hatahet et al, 2016). Each approach has its advantages and disadvantages, related not only to the ability to control particle size distribution (mono-vs.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Scale-up from batch to flow-through wet milling process for injectable depot formulation

Lehocký

Pěček²,

Štěpánek

2016

European Journal of Pharmaceutical Sciences

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Injectable depot formulations are aimed at providing long-term sustained release of a drug into systemic circulation, thus reducing plasma level fluctuations and improving patient compliance. The particle size distribution of the formulation in the form of suspension is a key parameter that controls the release rate. In this work, the process of wet stirred media milling (ball milling) of a poorly water-soluble substance has been investigated with two main aims: (i) to determine the parametric sensitivity of milling kinetics; and (ii) to develop scaleup methodology for process transfer from batch to flow-through arrangement. Ball milling experiments were performed in two types of ball mills, a batch mill with a 30 ml maximum working volume, and a flow-through mill with a 250 ml maximum working volume. Milling parameters were investigated in detail by methodologies of QbD to map the parametric space.Specifically, the effects of ball size, ball fill level, and rpm on the particle breakage kinetics were systematically investigated at both mills, with an additional parameter (flow-rate) in the case of the flow-through mill. The breakage rate was found to follow power-law kinetics with respect to dimensionless time, with an asymptotic d 50 particle size in the range of 200-300 nm.In the case of the flow-through mill, the number of theoretical passes through the mill was found to be an important scale-up parameter.

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Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology

Cited by 56 publications

References 18 publications

Application of VATS in Diagnosis and Treatment of Lung Cancer Complicated with Pneumothorax

Application of VATS in Diagnosis and Treatment of Lung Cancer Complicated with Pneumothorax

Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model

Scale-up from batch to flow-through wet milling process for injectable depot formulation

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