Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation

Matsumoto, Hisatake; Yamakawa, Kazuma; Ogura, Hiroshi; Koh, Taichin; Matsumoto, Naoya; Shimazu, Takeshi

doi:10.1097/shk.0000000000000331

Cited by 48 publications

(55 citation statements)

References 36 publications

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“…As such, MV-TF activity and IL-8 may have utility as an early prognostic marker for patients with influenza A/H1N1. These findings build on and extend observations made in bacterial sepsis and acute allograft rejection, where TF+ MVs correlate with adverse clinical outcomes (9–11). Moreover, since early plasma-based biomarkers for predicting influenza-related mortality remain largely absent, these results may be utilized to improve prognostication and risk-stratification efforts in the early stages of treatment for patients with severe influenza.…”

Section: Discussionsupporting

confidence: 85%

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

Rondina

Tatsumi

Bastarache

et al. 2016

Critical Care Medicine

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Objective To identify plasma biomarkers that can be early predictors of mortality in critically ill patients with primary influenza A/H1N1. Design A prospective, multicenter, case-cohort pilot study. Setting Three academic ICUs. Patients Fifteen patients with primary influenza A/H1N1 that included 7 survivors and 8 non-survivors. For comparison, age- and gender-matched healthy controls (n=27) were also studied. Interventions Plasma was prepared from whole blood drawn upon ICU admission in influenza patients (ICU day 1). Microvesicle tissue factor (MV-TF) activity, thrombin-antithrombin complexes (TATc), and D-dimers were measured as procoagulant markers and markers of activation of coagulation. Plasma cytokine levels were measured on the same blood samples in a subset of 12 influenza patients using the Luminex Multi-Analyte Profiling system. Patients were followed for the primary outcome of 28-day mortality. Measurements and Main Results The average admission APACHE II score of the patients was 25.5±9.3, 60% of patients had shock, and the 28-day mortality rate was 53.3% (n=8/15). Influenza patients had dysregulated indices of coagulation and inflammation compared to controls. Among the markers of activation of coagulation measured on ICU day 1, only increased MV-TF activity was significantly associated with subsequent influenza-related mortality (5.6±1.2 pg/ml in non-survivors vs. 1.8±0.8 pg/mL in survivors, p < 0.05). IL-8 was significantly higher in non-survivors compared with survivors (71.8±29.1 pg/ml, n=5 vs. 17.3±3.7 pg/mL, n=7, p < 0.05). In addition, MV-TF activity and IL-8 levels were significantly and positively correlated (r2 = 0.60, P=0.003). Other cytokines, TATc, and D-dimer were not different between non-survivors and survivors and did not correlate with illness severity or mortality. Conclusions This study identifies an association between plasma IL-8 and MV-TF activity measured upon admission in patients with severe, primary influenza A/H1N1 infection and subsequent mortality. Thus, these biomarkers may serve as very early prognostic markers for patients with influenza A/H1N1.

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Section: Discussionsupporting

confidence: 85%

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

Rondina

Tatsumi

Bastarache

et al. 2016

Critical Care Medicine

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“…For example, antithrombin and activated protein C concentrations decrease, as does endothelial glycosaminoglycans, such as heparan sulfate 83 . Inhibition of both thrombomodulin and endothelial cell protein C receptor contributes to the decrease in activated protein C concentrations 84 . Simultaneously, fibrinolysis is dramatically decreased.…”

Section: Mechanisms/pathophysiologymentioning

confidence: 99%

Sepsis and septic shock

Hotchkiss

Moldawer

Opal

et al. 2016

Nat Rev Dis Primers

1,191

1,005

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For more than two decades, sepsis was defined as a microbial infection that produces fever (or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now increasingly being considered a dysregulated systemic inflammatory and immune response to microbial invasion that produces organ injury for which mortality rates are declining to 15–25%. Septic shock remains defined as sepsis with hyperlactataemia and concurrent hypotension requiring vasopressor therapy, with in-hospital mortality rates approaching 30–50%. With earlier recognition and more compliance to best practices, sepsis has become less of an immediate life-threatening disorder and more of a long-term chronic critical illness, often associated with prolonged inflammation, immune suppression, organ injury and lean tissue wasting. Furthermore, patients who survive sepsis have continuing risk of mortality after discharge, as well as long-term cognitive and functional deficits. Earlier recognition and improved implementation of best practices have reduced in-hospital mortality, but results from the use of immunomodulatory agents to date have been disappointing. Similarly, no biomarker can definitely diagnose sepsis or predict its clinical outcome. Because of its complexity, improvements in sepsis outcomes are likely to continue to be slow and incremental.

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“…Additionally, we included 25 publications that fulfilled inclusion criteria but were found otherwise. Final analysis was performed on 65 publications (Fig. ).…”

Section: Designmentioning

confidence: 99%

Applicability of extracellular vesicles in clinical studies

Vozel

Uršič

Krek

et al. 2017

Eur J Clin Investigation

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Background Extracellular vesicles (EVs) are submicron cellular fragments that mediate intercellular communication. EVs have in the last decade attracted major interest as biomarkers or platforms for biomarkers of health and disease. To better understand the reasons why despite great expectations and considerable effort, EV-based methods have not yet been introduced into clinical practice, we present a systematic analysis of published results of clinical studies.

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Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation

Cited by 48 publications

References 36 publications

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

Sepsis and septic shock

Applicability of extracellular vesicles in clinical studies

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