Enhanced expression of CYP2C9 and tolerance to sulfonylurea herbicides in transgenic rice plants

Hirose, Sakiko; Kawahigashi, Hiroyuki; Inoue, Tomomi; Inui, Hideyuki; Ohkawa, Hideo; Ohkawa, Yasunobu

doi:10.5511/plantbiotechnology.22.89

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…Furthermore, several P450s were described as able to metabolize polycyclic aromatic hydrocarbons (PAHs) [66]. Besides detoxification of pollutants, engineered plants were also developed to contain mammalian CYPs, conferring a resistance to herbicides [67]. docking studies and high conservation of CYPs sequences alignment analysis, an engineered biocatalyst demonstrated enhanced activity for the terminal hydroxylation of short to long chain fatty acids [26].…”

Section: Deployment Of P450s In Bioremediation Processmentioning

confidence: 99%

An Overview of P450 Enzymes: Opportunity and Challenges in Industrial Applications

Notonier¹,

Alex²,

er³

et al. 2016

Enz Eng

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Cytochrome P450 enzymes (P450s) containing a heme-iron center, are biocatalysts from all kingdoms, involved in a large variety of reactions. Their potential in catalyzing a broad range of substrates makes perfect candidates for biotechnology applications and the production of high-value compounds. Biocatalytic reactions performed by P450s have a great interest in the pharmaceutical industry, fine chemicals, cosmetics, and for bioremediation procedures. However, the complex nature of this protein is still a major hurdle in the prospect of using their promising ability for expanding the number of industrial applications. Multiple approaches of protein engineering are currently conducted to improve activity, stability and/or substrate specificity for a given reaction. Furthermore, in combination with the appropriate biocatalyst, a suitable bioengineering process is a key step in the implementation of P450s at the industrial scale.

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Section: Deployment Of P450s In Bioremediation Processmentioning

confidence: 99%