Enhanced fibroblast cell adhesion on Al/Al2O3 nanowires

Aktas, Oral Cenk; Sander, M.; Miró, Marina Martinez; Lee, Juhan; Akkan, Cağrı Kaan; Smail, Heman A.; Ott, Albrecht; Veith, Michael

doi:10.1016/j.apsusc.2010.11.054

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…We have shown that our surface composed of Al/Al 2 O 3 bi-phasic and stoichiometric nanowires promotes the adhesion of fibroblast cells. 75 Fibroblasts grow well on this inorganic layer and keep proliferating. Using the cell monolayer rheology (CMR) technique, we have shown that the adhesion of fibroblasts on surfaces composed of Al/Al 2 O 3 nanowires is quantitatively comparable to fibronectin coated surfaces.…”

Section: Quantisation Of Cell Adhesion On Al/al 2 O 3 Nanowiresmentioning

confidence: 99%

Bi-phasic nanostructures for functional applications

et al. 2012

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Biphasic solid state composites of the type metal/metal oxide or element/element oxide can be synthesized in one pot chemical reactions using so called molecular "single source precursors". Due to their singular genesis these composites show peculiar hetero-structures based on core-shell hierarchies such as superlattices and composite nanospheres or nanowires. They exhibit superior or new functional properties compared to their individual constituent compounds. In the current work, we review in particular the synthetical and mechanistical approach of bi-phasic (Al/Al(2)O(3)) nanostructures such as nanospheres, nanowires and nanoloops using a single source precursor. Other bi-phasic materials of the general formula M/MO(x) (for example M = Ge, Sn, Pb) are addressed for comparison. The impact of different synthetical conditions as well as of modification of surfaces by laser techniques and their technological relevance are presented briefly. Additionally, functional applications of the prepared surfaces are explained with some outstanding case studies. These case studies are primarily concerned with their use as biomaterials and their application in medicine as well as with their use as thin films for optics and functional surfaces.

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Section: Quantisation Of Cell Adhesion On Al/al 2 O 3 Nanowiresmentioning

confidence: 99%

Bi-phasic nanostructures for functional applications

et al. 2012

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“…Previously we have shown the effect of the topography (regardless from the surface chemistry) on the cell adhesion and proliferation using randomly distributed Al 2 O 3 structures prepared by pulsed laser treatment of biphasic Al/Al 2 O 3 nanowires (NWs). Especially surfaces which are composed Al 2 O 3 nano‐ and microstructures seem to improve adhesion and proliferation of normal human dermal fibroblasts (NHDF) . On the other hand in some applications such as targeted re‐innovation, a directional growth of cells is also desired in addition to improved adhesion and proliferation.…”

Section: Introductionmentioning

confidence: 99%

Guidance of glial cells and neurites from dorsal root ganglia by laser induced periodic patterning of biphasic core/shell nanowires

Lee

Schwarz

Akkan

et al. 2013

Physica Status Solidi (a)

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Modification of topography is an effective tool to control the cellular response such as cell function, adhesion and proliferation on surfaces. In this work, we present a novel method for fabrication of periodic surface structures by laser interference patterning (LIP) of biphasic Al/Al 2 O 3 nanowires (NWs). These structures have a periodicity of 1-8 mm and a depth of 300-600 nm, depending on the incidence angle of the laser beam. Such hierarchical structures are composed of both micro-and nanofeatures. These periodic patterns lead to an alignment of glial cells and an axonal guidance from cultured dorsal root ganglia (DRG), along defined directions. The most pronounced alignment was seen at a periodicity of 2 mm.(a) Random growth of neurites on as-deposited chaotic NWs. (b) Aligned growth of neurites on patterned NWs.

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“…It was reported that even a small amount of vitronectin and fibronectin at the surface of ferrogel substantially promoted the adhesion of cells due to the presence of a specific amino acid sequence (Arg-Gly-Asp) in their chemical structure, which is favorable for the interaction with membrane receptors of fibroblasts [48,49]. Similar results were obtained for the adhesion and proliferation of human fibroblasts on the surface of Al/Al 2 O 3 bi-phasic nanowires (NWs) [50].…”

Section: Discussionmentioning

confidence: 52%

Magnetic Properties of Iron Oxide Nanoparticles Do Not Essentially Contribute to Ferrogel Biocompatibility

et al. 2021

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Two series of composite polyacrylamide (PAAm) gels with embedded superparamagnetic Fe2O3 or diamagnetic Al2O3 nanoparticles were synthesized, aiming to study the direct contribution of the magnetic interactions to the ferrogel biocompatibility. The proliferative activity was estimated for the case of human dermal fibroblast culture grown onto the surfaces of these types of substrates. Spherical non-agglomerated nanoparticles (NPs) of 20–40 nm in diameter were prepared by laser target evaporation (LTE) electrophysical technique. The concentration of the NPs in gel was fixed at 0.0, 0.3, 0.6, or 1.2 wt.%. Mechanical, electrical, and magnetic properties of composite gels were characterized by the dependence of Young’s modulus, electrical potential, magnetization measurements on the content of embedded NPs. The fibroblast monolayer density grown onto the surface of composite substrates was considered as an indicator of the material biocompatibility after 96 h of incubation. Regardless of the superparamagnetic or diamagnetic nature of nanoparticles, the increase in their concentration in the PAAm composite provided a parallel increase in the cell culture proliferation when grown onto the surface of composite substrates. The effects of cell interaction with the nanostructured surface of composites are discussed in order to explain the results.

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Enhanced fibroblast cell adhesion on Al/Al2O3 nanowires

Cited by 9 publications

References 16 publications

Bi-phasic nanostructures for functional applications

Bi-phasic nanostructures for functional applications

Guidance of glial cells and neurites from dorsal root ganglia by laser induced periodic patterning of biphasic core/shell nanowires

Magnetic Properties of Iron Oxide Nanoparticles Do Not Essentially Contribute to Ferrogel Biocompatibility

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