Enhanced formation of advanced oxidation protein products in IBD

Krzystek−Korpacka, Małgorzata; Neubauer, Katarzyna; Berdowska, Izabela; Boehm, Dorota; Zieliński, Bogdan; Petryszyn, Paweł; Terlecki, Grzegorz; Paradowski, Leszek; Gamian, Andrzej

doi:10.1002/ibd.20383

Cited by 63 publications

(56 citation statements)

References 36 publications

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“…In diabetic patients, correlation of IMA with the urinary albumin/ creatinine ratio and plasma creatinine concentration was observed. 32 Thus, IMA has been proposed as a biological marker of myocardial ischemia in suspected cases of acute coronary syndrome. Extracardiac oxidative stress could elevate IMA levels and thereby limit the usefulness of elevated IMA in the detection of cardiac ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…7,11 Plasma levels of IMA in T2DM is connected with parameters of oxidative processes such as AOPP and thiol groups (SH). 32 The ROC curve has become popular in recent years for evaluating the discriminatory power of tests, methods or parameters, and displays graphically the relationship between sensitivity and specificity over all possible decision values. The ROC curve also allows for comparison of the sensitivity and specificity over a wide range of cut-off points and the selection of the best diagnostic criterion for the test, methods or parameters.…”

Section: Discussionmentioning

confidence: 99%

“…12 Others showed that the diagnostic power of relative AOPP (plasma AOPP divided by plasma albumin) in discriminating patients with inflammatory states (inflammatory bowel disease) from nondiseased subjects was less than that of C-reactive protein (CRP), an often useful marker of inflammation. 32 Comparing the diagnostic usefulness of AOPP and IMA in estimating kidney dysfunction required evaluation of their ability to distinguishing individuals without any kidney disturbances (normoalbuminuria) from those with "upper normal" albuminuria manifested both by micro-and macroalbuminuria. According to these criteria, we observed that the mean AUC for IMA was larger than for AOPP but with appropriate cut-off values for AOPP and IMA, resulting from these ROC plots, we found similar sensitivity for these two parameters (87.38 and 81.55%, respectively), but different specificity (51.52 and 78.79%, respectively).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the usefulness of plasma levels of oxidatively modified forms of albumin in estimating kidney dysfunction in diabetic patients

Piwowar¹,

Knapik-Kordecka²,

Warwas³

2010

CIM

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Clin Invest Med 2010; 33 (2): E109-E116. AbstractPurpose: Advanced oxidation protein products (AOPP) and ischemia-modified albumin (IMA) are forms of oxidatidatively modified albumin and have recently been investigated as indicators of oxidative stress. They are increased in different disorders, including diabetes mellitus, as a result of hyperglycaemia, oxidative stress and hypoxia. The usefulness of the plasma levels of these two parameters in estimating kidney dysfunction in type 2 diabetic patients (T2DM) was compared in this study. Methods: Plasma levels of AOPP and IMA were determined spectrophotometrically in 218 individuals, 153 patients with T2DM and 65 healthy people.. The urinary albumin/creatinine ratio (UACR) was used as the reference to define the stage of kidney dysfunction by the assessment of the degree of albuminuria. Results: Receiver Operating Characteristic (ROC) curve analysis, likelihood ratio (LR), and Youden's index (J) revealed that AOPP and IMA had acceptable sensitivities and specificities in individuals with different degrees of albuminuria; however, AOPP had higher values of the area under the curve (AUC: 0.934) than IMA, as well as 100% sensitivity and 77.01% specificity for distinguishing patients with micro-and macroalbuminuria. Conclusions: Both AOPP and IMA may be helpful clinical markers for estimating kidney dysfunction, but AOPP is better able to identify diabetic patients with nephropathy. We suggest that AOPP is almost ideal for discriminating between T2DM patients with micro-and macroalbuminuria.In the plasma of diabetic patients, the albumin molecule is modified under conditions of chronic hypoxia, provoked mainly by the hyperglycaemia and oxidative stress (OS) existing in these patients. This leads to many changes in the structure and function of albumin including the formation of advanced oxidation protein products (AOPP) and ischemia-modified albumin (IMA). 1-4 AOPP were first detected in uremic and haemodialysed patients. They are formed during OS by the action of free radicals, mainly chloraminated oxidants (hypochlorous acid and chloramines) produced by myeloperoxidase in activated neutrophils. This leads to the formation of dityrosine residues and protein cross-linking, which results in abnormal albumin molecules in the plasma. AOPP are recognized as very good markers of oxidative damage to proteins and as indicators of disturbances in the oxidant/ antioxidant balance. 3,5,6 IMA is an albumin molecule modified by hypoxic conditions, which causes a ORIGINAL RESEARCH

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of the usefulness of plasma levels of oxidatively modified forms of albumin in estimating kidney dysfunction in diabetic patients

Piwowar¹,

Knapik-Kordecka²,

Warwas³

2010

CIM

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“…A large body of evidence exists that high-grade OxS has one of the crucial roles in the pathogenesis of disorders/diseases of the vascular system (atherosclerosis, myocardial infarction, stroke, peripheral artery disease), the nervous system (Alzheimer's disease, Parkinson's disease), the liver (cirrhosis, ethanol damage), the skin (dermatoses), the pancreas (diabetes mellitus), metabolic syndrome, obesity, premature ageing, the eyes (age-related macular degeneration, retinopathy), development of some tumors and the GI (inflammatory bowel disease, coeliac disease, etc), etc (Halliwell & Gutterridge, 1999;Stocker & Keaney, 2004;Kals et al, 2006;Stojiljkovic et al, 2007;Krzystek-Korpacka et al, 2008;Tsukahara, 2007;Suzuki et al, 2007;Vincent et al, 2007;Castellani et al, 2008). It has recently reviewed that harmful GI consequences of radiation therapy have OxS-related background (Spyropoulos et al, 2011).…”

Section: Short Survey Of Oxidative Stress-related Pathological Statesmentioning

confidence: 99%

Probiotics and Oxidative Stress

Kullisaar¹,

Songisepp²,

Zilmer³

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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“…Elevated levels of AOPPs are detected in many types of diseases, including osteoporosis (9)(10)(11)(12)(13)(14). Certain studies have demonstrated that oxidative stress leads to increased levels of AOPPs in osteoblastic MC3T3-E1 cells (15,16); AOPPs have been shown to inhibit the proliferation and differentiation of rat osteoblastic cells through NF-κB (17); these data suggest that AOPPs are associated with the progression of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Effect of advanced oxidation protein products on the proliferation and osteogenic differentiation of rat mesenchymal stem cells

Sun

Yang

et al. 2013

International Journal of Molecular Medicine

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Abstract. Advanced oxidation protein products (AOPPs) as a novel marker of oxidative stress, are involved in a variety of diseases, including osteoporosis. Although a number of studies have shown the possible functions of AOPPs in biological processes, little is known about the role of AOPPs in the pathogenesis of osteoporosis. In this study, we aimed to investigate the effect of AOPPs on the proliferation and osteogenic differentiation of rat mesenchymal stem cells (MSCs). MSCs, isolated from bone marrow, were cultured in the absence or presence of AOPPs (50, 100, 200 and 400 mg/ml). MTT assay was used to determine the proliferative ability of the cells. Alkaline phosphatase (ALP) activity, the mRNA expression of ALP and collagen I and bone nodule formation were detected to assess osteogenic differentiation. Reactive oxygen species (ROS) generation was analyzed with the probe 2' ,7'-dichlorodihydrofluorescein diacetate (DCFH-DA). The expression of receptor of advanced glycation end-products (RAGE) at the mRNA and protein level was detected by real-time PCR and western blot analysis, respectively. Compared with the control group, AOPPs inhibited MSC proliferation in a dose-and timedependent manner. Moreover, AOPPs induced a significant reduction in ALP activity, as well as a decrease in ALP and collagen I mRNA levels in the MSCs; bone nodule formation was also inhibited. Furthermore, AOPPs increased ROS generation in the MSCs, and upregulated the expression of RAGE at the mRNA and protein level. These results suggest that AOPPs inhibit the proliferation and osteogenic differentiation of MSCs, possibly through the AOPPs-RAGE-ROS pathway; this may be an important mechanism in the development of osteoporosis.

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Enhanced formation of advanced oxidation protein products in IBD

Cited by 63 publications

References 36 publications

Comparison of the usefulness of plasma levels of oxidatively modified forms of albumin in estimating kidney dysfunction in diabetic patients

Comparison of the usefulness of plasma levels of oxidatively modified forms of albumin in estimating kidney dysfunction in diabetic patients

Probiotics and Oxidative Stress

Effect of advanced oxidation protein products on the proliferation and osteogenic differentiation of rat mesenchymal stem cells

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