Enhanced Formation of Methylglyoxal-Derived Advanced Glycation End Products in Arabidopsis Under Ammonium Nutrition

Borysiuk, Klaudia; Ostaszewska-Bugajska, Monika; Vaultier, Marie‐Noëlle; Hasenfratz‐Sauder, Marie‐Paule; Szal, Bożena

doi:10.3389/fpls.2018.00667

Cited by 35 publications

(46 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned above, based on our own observations [67] and the data obtained by other groups [61,107], the main glycation pathways in plants are mediated by α-dicarbonyls. Although the most abundant plant α-dicarbonyl is GO, MGO is much better studied in terms of its formation, reactivity and biological role in plants.…”

Section: Possible Role Of Protein Glycation In Plant Physiologymentioning

confidence: 84%

Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?

Shumilina

Kusnetsova

Tsarev

et al. 2019

IJMS

View full text Add to dashboard Cite

Glycation can be defined as an array of non-enzymatic post-translational modifications of proteins formed by their interaction with reducing carbohydrates and carbonyl products of their degradation. Initial steps of this process rely on reducing sugars and result in the formation of early glycation products—Amadori and Heyns compounds via Schiff base intermediates, whereas their oxidative degradation or reactions of proteins with α-dicarbonyl compounds yield a heterogeneous group of advanced glycation end products (AGEs). These compounds accompany thermal processing of protein-containing foods and are known to impact on ageing, pathogenesis of diabetes mellitus and Alzheimer’s disease in mammals. Surprisingly, despite high tissue carbohydrate contents, glycation of plant proteins was addressed only recently and its physiological role in plants is still not understood. Therefore, here we summarize and critically discuss the first steps done in the field of plant protein glycation during the last decade. We consider the main features of plant glycated proteome and discuss them in the context of characteristic metabolic background. Further, we address the possible role of protein glycation in plants and consider its probable contribution to protein degradation, methylglyoxal and sugar signalling, as well as interplay with antioxidant defense.

show abstract

Section: Possible Role Of Protein Glycation In Plant Physiologymentioning

confidence: 84%

Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?

Shumilina

Kusnetsova

Tsarev

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…3P4 and 4P11, has revealed an increase in GLYI and GLYII activities in the plants subjected to both N-deficient and N-excess conditions, especially in the case, where ammonium was used as a N source [58]. In a similar context, the impact of MG in contributing towards NH 4 + toxicity symptoms in Arabidopsis has been recently studied [59]. Since effective incorporation of ammonium ions into the amino acid structures entails high activity of mitochondrial TCA and engagement of the glycolytic pathway, generation of MG is unavoidable under such circumstances.…”

Section: Discussionmentioning

confidence: 99%

From methylglyoxal to pyruvate: a genome-wide study for the identification of glyoxalases and D-lactate dehydrogenases in Sorghum bicolor

et al. 2020

View full text Add to dashboard Cite

Background: The glyoxalase pathway is evolutionarily conserved and involved in the glutathione-dependent detoxification of methylglyoxal (MG), a cytotoxic by-product of glycolysis. It acts via two metallo-enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII), to convert MG into D-lactate, which is further metabolized to pyruvate by D-lactate dehydrogenases (D-LDH). Since D-lactate formation occurs solely by the action of glyoxalase enzymes, its metabolism may be considered as the ultimate step of MG detoxification. By maintaining steady state levels of MG and other reactive dicarbonyl compounds, the glyoxalase pathway serves as an important line of defence against glycation and oxidative stress in living organisms. Therefore, considering the general role of glyoxalases in stress adaptation and the ability of Sorghum bicolor to withstand prolonged drought, the sorghum glyoxalase pathway warrants an in-depth investigation with regard to the presence, regulation and distribution of glyoxalase and D-LDH genes. Result: Through this study, we have identified 15 GLYI and 6 GLYII genes in sorghum. In addition, 4 D-LDH genes were also identified, forming the first ever report on genome-wide identification of any plant D-LDH family. Our in silico analysis indicates homology of putatively active SbGLYI, SbGLYII and SbDLDH proteins to several functionally characterised glyoxalases and D-LDHs from Arabidopsis and rice. Further, these three gene families exhibit development and tissue-specific variations in their expression patterns. Importantly, we could predict the distribution of putatively active SbGLYI, SbGLYII and SbDLDH proteins in at least four different sub-cellular compartments namely, cytoplasm, chloroplast, nucleus and mitochondria. Most of the members of the sorghum glyoxalase and D-LDH gene families are indeed found to be highly stress responsive.Conclusion: This study emphasizes the role of glyoxalases as well as that of D-LDH in the complete detoxification of MG in sorghum. In particular, we propose that D-LDH which metabolizes the specific end product of glyoxalases pathway is essential for complete MG detoxification. By proposing a cellular model for detoxification of MG via glyoxalase pathway in sorghum, we suggest that different sub-cellular organelles are actively involved in MG metabolism in plants.

show abstract

“…The glycolytic metabolism produces methylglyoxal (MG) as a toxic by-product, which severely inhibits cell growth in plants. The MG content steeply increases during abiotic stresses and is required to be neutralized in order to maintain the cellular physiology [73]. Banu et al [74] reported the exogenous application of GB to decrease the MG and H2O2 content in tobacco cells cultured in a saline medium.…”

Section: Glycinebetaine-induced Antioxidant Defensementioning

confidence: 99%

Targeting Glycinebetaine for Abiotic Stress Tolerance in Crop Plants: Physiological Mechanism, Molecular Interaction and Signaling

Hasanuzzaman¹,

Banerjee²,

Bhuyan³

et al. 2019

Phyton

View full text Add to dashboard Cite

In the era of climate change, abiotic stresses (e.g., salinity, drought, extreme temperature, flooding, metal/metalloid(s), UV radiation, ozone, etc.) are considered as one of the most complex environmental constraints that restricts crop production worldwide. Introduction of stress-tolerant crop cultivars is the most auspicious way of surviving this constraint, and to produce these types of tolerant crops. Several bioengineering mechanisms involved in stress signaling are being adopted in this regard. One example of this kind of manipulation is the osmotic adjustment. The quarternary ammonium compound glycinebetaine (GB), also originally referred to as betaine is a methylated glycine derivative. Among the betaines, GB is the most abundant one in plants, which is mostly produced in response to dehydration caused by different abiotic stresses like drought, salinity, and extreme temperature. Glycinebetaine helps in decreased accumulation and detoxification of ROS, thereby restoring photosynthesis and reducing oxidative stress. It takes part in stabilizing membranes and macromolecules. It is also involved in the stabilization and protection of photosynthetic components, such as ribulose-1, 5-bisphosphate carboxylase/oxygenase, photosystem II and quarternary enzyme and protein complex structures under environmental stresses. Glycinebetaine was found to perform in chaperone-induced protein disaggregation. In addition, GB can confer stress tolerance in very low concentrations, and it acts in activating defense responsive genes with stress protection. Recently, field application of GB has also shown protective effects against environmental adversities increasing crop yield and quality. In this review, we will focus on the role of GB in conferring abiotic stress tolerance and the possible ways to engineer GB biosynthesis in plants.

show abstract

Enhanced Formation of Methylglyoxal-Derived Advanced Glycation End Products in Arabidopsis Under Ammonium Nutrition

Cited by 35 publications

References 92 publications

Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?

Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?

From methylglyoxal to pyruvate: a genome-wide study for the identification of glyoxalases and D-lactate dehydrogenases in Sorghum bicolor

Targeting Glycinebetaine for Abiotic Stress Tolerance in Crop Plants: Physiological Mechanism, Molecular Interaction and Signaling

Contact Info

Product

Resources

About