Enhanced Glucose Sensor Linearity Using Poly(Vinyl Alcohol) Hydrogels

Vaddiraju, Santhisagar; Singh, Hardeep; Burgess, Diane J.; Jain, F.; Papadimitrakopoulos, Fotios

doi:10.1177/193229680900300434

Cited by 42 publications

(41 citation statements)

References 39 publications

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“…This leads to the production of H 2 O 2 as shown in reaction 2 of Figure 2A. 9,10 The glucose concentration can be correlated to the amperometric signal obtained either via the electrochemical oxidation of the produced H 2 O 2 (reaction 3 of Figure 2A) or via the electrochemical reduction of O 2 (reaction 4 of Figure 2A) at the working electrode.…”

Section: Figure 2 Illustrates Various Enzymaticmentioning

confidence: 99%

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Vaddiraju

Burgess

Tomazos

et al. 2010

J Diabetes Sci Technol

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Devices for continuous glucose monitoring (CGM) are currently a major focus of research in the area of diabetes management. It is envisioned that such devices will have the ability to alert a diabetes patient (or the parent or medical care giver of a diabetes patient) of impending hypoglycemic/hyperglycemic events and thereby enable the patient to avoid extreme hypoglycemic/hyperglycemic excursions as well as minimize deviations outside the normal glucose range, thus preventing both life-threatening events and the debilitating complications associated with diabetes. It is anticipated that CGM devices will utilize constant feedback of analytical information from a glucose sensor to activate an insulin delivery pump, thereby ultimately realizing the concept of an artificial pancreas. Depending on whether the CGM device penetrates/breaks the skin and/or the sample is measured extracorporeally, these devices can be categorized as totally invasive, minimally invasive, and noninvasive. In addition, CGM devices are further classified according to the transduction mechanisms used for glucose sensing (i.e., electrochemical, optical, and piezoelectric). However, at present, most of these technologies are plagued by a variety of issues that affect their accuracy and long-term performance. This article presents a critical comparison of existing CGM technologies, highlighting critical issues of device accuracy, foreign body response, calibration, and miniaturization. An outlook on future developments with an emphasis on long-term reliability and performance is also presented.

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Section: Figure 2 Illustrates Various Enzymaticmentioning

confidence: 99%

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Vaddiraju

Burgess

Tomazos

et al. 2010

J Diabetes Sci Technol

Self Cite

230

224

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“…[15] In addition, the PVA hydrogel possess sufficient permeability to small molecules (such as glucose and O 2 ) and is capable of supplemental oxygen storage both of which lead to adequate sensor sensitivity and linearity. [16] In this manuscript, we present yet another advantage of the dexamethasone-releasing PLGA/PVA composite which is the increase in glucose permeability following microsphere degradation. It was shown that PLGA microsphere degradation within the PVA hydrogel results in a 50% increase in glucose flux over a period of 30 days when investigated in simple PBS buffer solutions, with a concomitant increase in the sensitivity of PLGA/PVA-coated glucose sensors.…”

Section: Introductionmentioning

confidence: 97%

Macroscopic porosity generation in outer hydrogel membranes to offset sensitivity loss in implantable glucose sensors

Vaddiraju

Wang

Qiang

et al. 2013

2013 IEEE International Conference on Body Sensor Networks

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The function of implantable glucose sensor is hindered by post-implantation effects such as biofouling and negative tissue responses both of which lead to permeability reducing fibrous encapsulation. Utilization of drug-eluting composite coatings based on dexamethasone-containing poly (lactic-coglycolic) acid (PLGA) microspheres and poly (vinyl alcohol) (PVA) hydrogel matrix has been shown to suppress inflammation over a period of 1-3 months. Herein, it is shown that these coatings provide another auxiliary venue to offset the negative effects of protein adsorption through generation of macroscopic porosity following microsphere degradation. Long-term studies in serum have indicated that, while biofouling clogs the microporosity of the hydrogel, it has been offset by the generated macroscopic porosity following microsphere degradation. This resulted in a two-fold recovery in sensor sensitivity as compared to controls. These findings suggest that the use of macroscopic porosity can reduce biofouling-induced sensitivity losses, an approach synergistic with drug-delivery based methodologies to mitigate negative tissue responses.

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“…Biocompatible polymeric membranes and coatings have been implemented in the field of biosensors such as the implantable glucose sensors, which have played a leading role on the blood glucose continuous monitoring. Several types of polymers have been employed for preparation of glucose biosensors, such as poly(vinyl alcohol) hydrogels [29], hydrophilic polyurethane with polyvinyl alcohol/ vinyl butyral copolymer [30], poly(2-hydroxyethylmethacrylate) (polyHEMA) [31], polylactic-co-glycolicacid (PLGA) [32], etc.…”

Section: Introductionmentioning

confidence: 99%

Experimental investigation of the transport mechanism of several gases during the CVD post-treatment of nanoporous membranes

Labropoulos

Athanasekou

Kakizis

et al. 2014

Chemical Engineering Journal

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Enhanced Glucose Sensor Linearity Using Poly(Vinyl Alcohol) Hydrogels

Cited by 42 publications

References 39 publications

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Macroscopic porosity generation in outer hydrogel membranes to offset sensitivity loss in implantable glucose sensors

Experimental investigation of the transport mechanism of several gases during the CVD post-treatment of nanoporous membranes

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