2010
DOI: 10.1152/ajpendo.00741.2009
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Enhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization

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Cited by 12 publications
(10 citation statements)
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References 37 publications
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“…Basal adipocyte metabolism was unaffected by glycogen accumulation since similar cellular respiratory rates, metabolic gene expression and lactate release were observed in glycogen-loaded adipocytes and control cells ( Figure S4 ). Nevertheless, an increase in the sensitivity to the lipolytic agents isoproterenol and CL-316243 was evident in glycogen-loaded adipocytes ( Figure 2 H), supporting the metabolic link proposed previously between lipid and carbohydrate metabolism [16] , [32] .…”
Section: Resultssupporting
confidence: 87%
See 1 more Smart Citation
“…Basal adipocyte metabolism was unaffected by glycogen accumulation since similar cellular respiratory rates, metabolic gene expression and lactate release were observed in glycogen-loaded adipocytes and control cells ( Figure S4 ). Nevertheless, an increase in the sensitivity to the lipolytic agents isoproterenol and CL-316243 was evident in glycogen-loaded adipocytes ( Figure 2 H), supporting the metabolic link proposed previously between lipid and carbohydrate metabolism [16] , [32] .…”
Section: Resultssupporting
confidence: 87%
“…Interestingly, although adipocyte function appeared to be maintained in these animals, leptin, but not adiponectin, protein content in adipose tissue was increased, and the associated hyperleptinemia was independent of fat mass [15] . Further studies showed that upon caloric excess-induced expansion of adipose tissue mass, the elevated levels of glycogen in this model inhibited the mobilization of triglyceride and impeded weight loss following the return to chow feeding [16] .…”
Section: Introductionmentioning
confidence: 83%
“…An induction of adipose tissue lipogenesis (rather than hepatic lipogenesis) could mirror an increased efficiency of lipid storage during HFO, as reflected by the reduced fasting plasma NEFA and triacylglycerol levels observed in the young men after HFO. Moreover, the finding that genes involved in glycogen synthesis (GYS1 and GYS2) were among those most strongly upregulated by HFO is consistent with the suggestion that adipose glycogen turnover may help coordinate glucose and lipid metabolism in adipose tissue [35].…”
Section: Discussionsupporting
confidence: 83%
“…The relationship between the over-accumulation of glycogen and improved lipid retention was demonstrated by prior investigations that manipulated glycogen dynamics through use of a transgenic mouse model, which resulted in the marked, permanent over-accumulation of glycogen in EPI and IBAT. Persistent elevation of WAT glycogen levels slowed weight loss following a transition from high-fat diet to normal chow diet through the enhanced retention of free fatty acids in adipocytes [36], [63]. During the present study glycogen over-accumulation in the major WAT and BAT adipose depots may have enabled a similar lipid-retention effect.…”
Section: Discussionsupporting
confidence: 52%