Enhanced growth of animal and human endothelial cells on biodegradable polymers

Chu, Cecilia F.L; Lu, Albert K.; Liszkowski, Mark; Sipehia, R.

doi:10.1016/s0304-4165(99)00151-8

Cited by 90 publications

(58 citation statements)

References 16 publications

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“…The topographical features of a scaffold have a significant effect in tissue engineering and it has been demonstrated that the surface roughness of scaffolds affects cell behaviour, including cell attachment, proliferation and differentiation (Chen et al, 2007;Naji and Harmand, 1990;Meyer et al, 1993;Steele et al, 1993;Chu et al, 1999;Xu et al, 2004b). Moreover, the topographical features are described to have a positive effect on axonal orientation, where the physical guidance of axons is a vital component of nerve repair.…”

Section: Topographical Modification Of Conductive Scaffoldsmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

618

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Topographical Modification Of Conductive Scaffoldsmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

618

389

View full text Add to dashboard Cite

show abstract

“…Growth and organization of fibrovascular tissues inside polymer scaffolds lead to the occlusion of the regenerated blood vessel. Chu et al have employed a novel ammonia plasma technique to surface modify PLLA substrates and to provide regulatory mechanisms to control the development of an inner capsule and endothelialization of the materials [215]. In this work, an rf plasma generator is capacitively coupled to a plasma reactor.…”

Section: Other Polymersmentioning

confidence: 99%

Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,424

652

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Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #

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“…Certain polymer surfaces exposed to N2 and O2 in Helium display enhanced attachment properties, with the extent of surface modification depending upon the polymer surface itself [21,47]. Other surfaces exposed to nitrogen gases have been known to exhibit reduced thrombotic properties [3,88]. As with etching, plasma processes cause the formation of free radicals at the material surface, causing the formation of cross-links [25].…”

Section: Chemical Modification Of the Surfacementioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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Enhanced growth of animal and human endothelial cells on biodegradable polymers

Cited by 90 publications

References 16 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Plasma-surface modification of biomaterials

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

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