2012
DOI: 10.1128/jvi.06009-11
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Enhanced Growth of Influenza Vaccine Seed Viruses in Vero Cells Mediated by Broadening the Optimal pH Range for Virus Membrane Fusion

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Cited by 64 publications
(66 citation statements)
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“…Differences in M2 activity of the pLAIV viruses compared to that of the corresponding wt virus may have a detrimental effect on the acid stability of the pLAIV viruses. The pLAIV viruses may be more suited to replication in cells with a higher endosomal pH (69). It is apparent from our study and others that the compatibility between HA and M requires an optimal functional interaction (63).…”
Section: Figmentioning
confidence: 53%
“…Differences in M2 activity of the pLAIV viruses compared to that of the corresponding wt virus may have a detrimental effect on the acid stability of the pLAIV viruses. The pLAIV viruses may be more suited to replication in cells with a higher endosomal pH (69). It is apparent from our study and others that the compatibility between HA and M requires an optimal functional interaction (63).…”
Section: Figmentioning
confidence: 53%
“…The reduced stability of (H1N1)pdm09 HA likely makes it more susceptible to pH or other environmental stresses. Several groups have shown that the stability of HA varies greatly among different virus strains that have adapted to different environmental conditions and hosts (21,(58)(59)(60)(61)(62)(63)(64)(65)(66) (58). Pathogenic H7 HA proteins can vary up to 0.6 pH unit in their pH of fusion activation (9).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have provided evidence that the pH of fusion is crucial for influenza virus infection in distinct organisms (23)(24)(25). It was further shown that viral adaptation to different host cells and species often necessitates mutations in the HA protein, altering the fusion pH to account for host-specific variations in the endosomal pH and/or for different transmission modes (36,(54)(55)(56)(57)(58). In particular, it has been shown that a high pH of fusion increases the pathogenicity of the virus in infected chicken and ducks (22,24), whereas a high pH is not favorable for infection of and spread between mammals (23,25,36,54,55,58).…”
Section: Discussionmentioning
confidence: 99%