Enhanced hemostasis with a sealant consisting of Hydrofit and Surgicel

Ishii, Hikaru; Endo, Hidehito; Kubota, Hiroshi

doi:10.1111/jocs.13202

Cited by 10 publications

(3 citation statements)

References 3 publications

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“…Hydrofit (Sanyo Medical Industry, Ltd., Kyoto, Japan) is a novel synthetic sealant recently developed in Japan and formed by a reaction between a copolymer of PEG and fluorinated hexamethylene diisocyanate (FHD). Hydrofit has a high hemostatic ability and is safe and effective in thoracic aortic surgery [5]. However, this liquid agent can be difficult to use, thus requiring skill and experience [6].…”

Section: Discussionmentioning

confidence: 99%

In vivo hemostatic capability of a novel Tetra-PEG hydrogel

Okata

Hoshina

Hanada

et al. 2021

Preprint

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TetraStat is a novel synthetic sealant created with a tetra-armed polyethylene glycol (PEG) hydrogel. It has no risk of infection from biological pathogens and has a hemostatic mechanism independent of the blood coagulation pathway and controllable gelation. We evaluated the hemostatic effect of TetraStat in ex vivo and in vivo experiments for future clinical application. In ex vivo experiments using a circulatory system filled with phosphate-buffered saline under high pressure, needle punctures were astricted with TetraStat and two commercially available hemostatic agents (SURGICEL and TachoSil). For in vivo experiments, rat vena cavae were punctured with 14, 18, and 20 gauge needles, and hemorrhage occurred for several seconds. A porous PEG sponge soaked with TetraStat was applied as a hemostatic system for the massive hemorrhage. In the ex vivo experiment, punctures were sealed completely after 1 min astriction with TetraStat gel; in contrast, SURGICEL and TachoSil failed to seal the hole. In vivo experiments demonstrated that TetraStat successfully caused hemostasis in the punctured vena cava within 1 min of application in a dose-dependent manner. For SURGICEL and TachoSil, successful hemostasis occurred after 5 min astriction but was less frequent after 1 min astriction. Ex vivo and in vivo experiments revealed TetraStat’s high hemostatic ability under high pressure and in rat vena cava injuries under massive hemorrhage. A porous PEG sponge soaked with TetraStat is a promising advancement in hemostatic systems.

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Section: Discussionmentioning

confidence: 99%

In vivo hemostatic capability of a novel Tetra-PEG hydrogel

Okata

Hoshina

Hanada

et al. 2021

Preprint

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“…Hydrofit has high hemostatic ability and is safe and effective in thoracic aortic surgery. [6] We assumed that this sealant could be strongly competitive with TetraStat as it has similar PEG components and hemostatic procedures.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Hemostatic Capability of a Novel Tetra-Polyethylene Glycol Hydrogel

Okata

Hoshina

Hanada

et al. 2022

Annals of Vascular Surgery

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“…Several techniques have been reported for preventing anastomotic bleeding. [1][2][3] The most common technique is reinforcing the anastomosis site with a felt strip. However, regarding needle-hole bleeding, transfelt strip oozing is a concern because of the high porosity of felt strips.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcome of the Type A Acute Aortic Dissection Repair Using the “Tailored Stand-Up Collar” Technique

Umeda,

Inoue,

Mitta

et al. 2024

ATCS

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Purpose: Achieving a secure anastomosis and complete hemostasis is essential for surgically treating type A acute aortic dissection (TAAAD). This study assessed the clinical feasibility of “tailored stand-up collar (TSC)” technique for constructing the distal stump. Methods: We enrolled 68 patients who underwent ascending aortic repair for TAAAD. Patients were categorized according to the technique for distal stump construction: conventional (C) group using only a felt strip (32 cases); post-aortotomy (P) group, with a Hydrofit-felt strip attached after aortotomy (18 cases), and TSC group, where a Hydrofit-felt strip attached during cooling (18 cases). Pre-operative characteristics, procedural profiles, and post-operative outcomes were evaluated. Results: The pre-operative characteristics were identical among the groups. The durations of cardiopulmonary bypass, hemostasis, and surgery were significantly shorter in the P and TSC groups. The duration of open distal in the TSC group (21 min) was significantly shorter than the other two groups. Post-operative additional procedures were not required for the TSC group and their post-operative hospital stay was significantly shorter (47.1% of patients were discharged within 2 weeks). Conclusion: The TSC technique would be practical because of its high reproducibility in terms of ease of use, shorter anastomotic time, and secure hemostasis.

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Enhanced hemostasis with a sealant consisting of Hydrofit and Surgicel

Cited by 10 publications

References 3 publications

In vivo hemostatic capability of a novel Tetra-PEG hydrogel

In vivo hemostatic capability of a novel Tetra-PEG hydrogel

Hemostatic Capability of a Novel Tetra-Polyethylene Glycol Hydrogel

Clinical Outcome of the Type A Acute Aortic Dissection Repair Using the “Tailored Stand-Up Collar” Technique

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