Enhanced high-temperature electrical response of hydroxyapatite upon grain size refinement

Lukić, Miodrag J.; Jovalekić, Čedomir; Marković, Smilja; Uskoković, Dragan

doi:10.1016/j.materresbull.2014.10.072

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…The room for such improvements is apparently limitless. As for the control of microstructure, it is known that parameters such as morphology [6], crystallinity [7], grain [8] and particle size [9,10], topography [11], porosity [12] or compositional gradient [13] have an immense effect on the physical properties and bioactivity of HAp. As for doping HAp, each of its three constitutive ions — calcium, phosphate and hydroxyl — can be substituted with other ions and dozens of chemically different forms of HAp are known so far [14].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissues

Ignjatović

Ajduković

et al. 2016

Materials Science and Engineering: C

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Composite biomaterials comprising nanostructured hydroxyapatite (HAp) have an enormous potential for natural bone tissue reparation, filling and augmentation. Chitosan (Ch) as a naturally derived polymer has many physicochemical and biological properties that make it an attractive material for use in bone tissue engineering. On the other hand, poly-D,L-lactide-co-glycolide (PLGA) is a synthetic polymer with a long history of use in sustained drug delivery and tissue engineering. However, while chitosan can disrupt the cell membrane integrity and may induce blood thrombosis, PLGA releases acidic byproducts that may cause tissue inflammation and interfere with the healing process. One of the strategies to improve the biocompatibility of Ch and PLGA is to combine them with compounds that exhibit complementary properties. In this study we present the synthesis and characterization, as well as in vitro and in vivo analyses of a nanoparticulate form of HAp coated with two different polymeric systems: (a) Ch and (b) a Ch-PLGA polymer blend. Solvent/non-solvent precipitation and freeze-drying were used for synthesis and processing, respectively, whereas thermogravimetry coupled with mass spectrometry was used for phase identification purposes in the coating process. HAp/Ch composite particles exhibited the highest antimicrobial activity against all four microbial strains tested in this work, but after the reconstruction of the bone defect they also caused inflammatory reactions in the newly formed tissue where the defect had lain. Coating HAp with a polymeric blend composed of Ch and PLGA led to a decrease in the reactivity and antimicrobial activity of the composite particles, but also to an increase in the quality of the newly formed bone tissue in the reconstructed defect area.

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Section: Introductionmentioning

confidence: 99%

Chitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissues

Ignjatović

Ajduković

et al. 2016

Materials Science and Engineering: C

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“…The effects of microstructural refinement on the enhanced electrical properties of hydroxyapatite should be understood from the point of view of the prevented depletion of OH -, as the main charge carriers, and the shortening of charge transport pathways in dense nano-grained hydroxyapatite ceramics. 27 The chemical precipitation method was also used for the preparation of hydroxyapatite nano-powders in the presence of different concentrations of zirconium ions. 28 HAp/ZrO 2 composites had improved properties, especially mechanical, while biocompatibility was not impaired, when compared to pure HAp.…”

Section: Full Density Nanostructured Calcium Phosphate and Functionalmentioning

confidence: 99%

Molecular designing of nanoparticles and functional materials

Ignjatović

Marković

Jugović

et al. 2017

JSCS

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The interdisciplinary research team implemented the program titled "Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them" (MODENAFUNA), between 2011 and 2016, gaining new knowledge significant to the further improvement of nanomaterials and nanotechnologies. It gathered under its umbrella six main interrelated topics pertaining to the design and control of morphological and physicochemical properties of nanoparticles and functional material based on them using new methods of synthesis and processing: 1) inorganic nanoparticles, 2) cathode materials for lithium-ion batteries, 3) functional ceramics with improved electrical and optical properties, 4) full density nanostructured calcium phosphate and functionally-graded materials, 5) nano-calcium phosphate in bone tissue engineering and 6) biodegradable micro-and nano-particles for the controlled delivery of medicaments.

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“…Materials based on hydroxyapatite (HAp) ceramics are widely studied as components for medical applications, sensors, magnetic separations, catalyst support, etc [1][2][3][4]. Different engineering and scientific approaches, like microstructural optimization [5][6][7][8] and addition of different additives [9,10], were implemented for enhancement of functional response. Numerous alkali-based compounds were investigated as useful additives for inducing liquid phase formation during HAp sintering [11].…”

Section: Introductionmentioning

confidence: 99%

Inert atmosphere processing of hydroxyapatite in the presence of lithium iron phosphate

Lukić

Kuzmanović

Sezen

et al. 2018

Journal of the European Ceramic Society

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The present study describes sintering behaviour of hydroxyapatite (HAp) upon addition of lithium iron phosphate (LFP) (1-10 wt. %) system in inert (Ar) atmosphere. The interaction between materials and melting of LFP influenced early and intermediate stages of HAp sintering, shifting the densification curves towards low-temperature side. Analysis of densification process indicated significant differences upon LFP addition. The reaction mechanism that assumes the initial interaction between phosphates from LFP and calcium from HAp was proposed, generating calcium vacancies and contributing to HAp densification. Cross-sections of sintered samples showed changes in microstructural properties, with uniform atomic distribution and presence of Li 2 Fe 3 O 4 spherical inclusions (200 nm) located at grain boundaries of calcium phosphate matrix. The Rietveld refinement analysis indicated changes in structural and microstructural parameters like crystallite size, anisotropy and microstructural strain of HAp upon LFP addition. Mechanical characterisation indicated improvements in fracture behaviour upon LFP addition.

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Enhanced high-temperature electrical response of hydroxyapatite upon grain size refinement

Cited by 8 publications

References 20 publications

Chitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissues

Chitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissues

Molecular designing of nanoparticles and functional materials

Inert atmosphere processing of hydroxyapatite in the presence of lithium iron phosphate

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