Advancements in wearable sensors technologies provide prominent effects in the daily life activities of humans. These wearable sensors are gaining more awareness in healthcare for the elderly to ensure their independent living and to improve their comfort. In this paper, we present a human activity recognition model that acquires signal data from motion node sensors including inertial sensors, i.e., gyroscopes and accelerometers. First, the inertial data is processed via multiple filters such as Savitzky–Golay, median and hampel filters to examine lower/upper cutoff frequency behaviors. Second, it extracts a multifused model for statistical, wavelet and binary features to maximize the occurrence of optimal feature values. Then, adaptive moment estimation (Adam) and AdaDelta are introduced in a feature optimization phase to adopt learning rate patterns. These optimized patterns are further processed by the maximum entropy Markov model (MEMM) for empirical expectation and highest entropy, which measure signal variances for outperformed accuracy results. Our model was experimentally evaluated on University of Southern California Human Activity Dataset (USC-HAD) as a benchmark dataset and on an Intelligent Mediasporting behavior (IMSB), which is a new self-annotated sports dataset. For evaluation, we used the “leave-one-out” cross validation scheme and the results outperformed existing well-known statistical state-of-the-art methods by achieving an improved recognition accuracy of 91.25%, 93.66% and 90.91% when compared with USC-HAD, IMSB, and Mhealth datasets, respectively. The proposed system should be applicable to man–machine interface domains, such as health exercises, robot learning, interactive games and pattern-based surveillance.