Enhanced <i>in vivo</i> antiviral activity against pseudorabies virus through transforming gallic acid into graphene quantum dots with stimulation of interferon-related immune responses

Ye, Shiyi; Su, Fei; Li, Junxing; Yu, Bin; Xu, Lihua; Xiong, Tao; Shao, Kang; Yuan, Xiufang

doi:10.1039/d3tb01844j

Cited by 7 publications

(1 citation statement)

References 43 publications

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“…Raghavan et al evaluated the potential of GQDs as neurotrophic agents and found the upregulation of neurotrophic factors in GQDs treating mouse neuroblastoma cells [290]. Ye et al reported that gallic acid derived GQDs showed antiviral activity against pseudorabies virus and regulated the expression of interferon-related antiviral proteins in vero cells [291].…”

Section: Therapeutic Agentsmentioning

confidence: 99%

A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)

Bae,

Cho,

Hong

2024

Nanotechnology

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A new type of 0-dimensional carbon-based materials called graphene quantum dots (GQDs) is gaining significant attention as a non-toxic and eco-friendly nanomaterial. GQDs are nanomaterials composed of sp2 hybridized carbon domains and functional groups, with their lateral size less than 10 nm. The unique and exceptional physical, chemical, and optical properties arising from the combination of graphene structure and quantum confinement effect due to their nano-size make GQDs more intriguing than other nanomaterials. Particularly, the low toxicity and high solubility derived from the carbon core and abundant edge functional groups offer significant advantages for the application of GQDs in the biomedical field. In this review, we summarize various synthetic methods for preparing GQDs and important factors influencing the physical, chemical, optical, and biological properties of GQDs. Furthermore, the recent application of GQDs in the biomedical field, including biosensor, bioimaging, drug delivery, and therapeutics are discussed. Through this, we provide a brief insight on the tremendous potential of GQDs in biomedical applications and the challenges that need to be overcome in the future.

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Section: Therapeutic Agentsmentioning

confidence: 99%

A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)

Bae,

Cho,

Hong

2024

Nanotechnology

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The role of graphene quantum dots in cutting‐edge medical therapies

Arab,

Jafari,

Shahi

2024

Polymers for Advanced Techs

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Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical properties, have emerged as promising nanomaterials for various biomedical applications. This review provides a comprehensive overview of the latest advancements in the utilization of GQDs in tissue engineering, wound healing, drug delivery systems, and other biomedical therapies. The inherent properties of GQDs, including high biocompatibility, tunable photoluminescence, and significant surface area, make them ideal candidates for enhancing medical treatments and diagnostics. In tissue engineering, GQDs improve the mechanical and biological performance of scaffolds, promoting cell proliferation and differentiation. For wound healing, GQDs enhance antimicrobial activity and facilitate faster tissue regeneration. Their potential in DDS is highlighted by their ability to deliver therapeutic agents efficiently, ensuring targeted and controlled release. Additionally, GQDs play a crucial role in biomedical therapies, particularly in cancer treatment, by enhancing drug efficacy and reducing side effects. While GQDs offer significant potential in enhancing medical treatments and diagnostics, challenges such as understanding their long‐term biocompatibility, potential cytotoxicity at higher concentrations, and the need for standardized synthesis methods remain critical areas for further research. This review also discusses the future directions and opportunities for GQDs, emphasizing their transformative potential in advancing modern healthcare solutions. The insights presented here contribute to the expanding field of GQD research, highlighting their potential to significantly enhance patient outcomes and drive healthcare innovations.

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Graphene Quantum Dots‐Based Materials as an Emerging Nanoplatform in Disease Diagnosis and Therapy

Bhatt,

Pathak,

Punetha

et al. 2024

Part & Part Syst Charact

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Graphene quantum dots are a subclass of graphene‐based materials that exhibit unique properties due to their nanoscale size and quantum confinement effects. Discovered in the early 21st century, these zero‐dimensional carbon nanomaterials have rapidly become important in nanotechnology research due to their diverse applications. In recent years, the medical community has been greatly benefited from these materials, significantly enhancing human health and well‐being with theranostic approaches. The present review explores various applications of graphene quantum dots in diagnostic and therapeutic, unraveling their potential contributions to advancing healthcare. Furthermore, this review elucidates the synthesis methods utilized for graphene quantum dots, encompassing a range of top‐down and bottom‐up approaches. Next, the unique fundamental properties including structural, optical, and electrical that make them a potent nanomaterial for use in healthcare have been elucidated for enhanced reader comprehension. Additionally, the review explores the opportunities and challenges ahead, offering valuable insights to help the scientific community strategically expand the potential of graphene quantum dot‐based materials for advanced theranostic healthcare applications.

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Enhanced in vivo antiviral activity against pseudorabies virus through transforming gallic acid into graphene quantum dots with stimulation of interferon-related immune responses

Abstract: With the urgent need of antiviral agents, antiviral materials with high biocompatibility and antiviral effects have attracted numerous attentions. In this study, gallic acid, a nature polyphenolic compound, was transformed...

Cited by 7 publications

References 43 publications

A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)

A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)

The role of graphene quantum dots in cutting‐edge medical therapies

Graphene Quantum Dots‐Based Materials as an Emerging Nanoplatform in Disease Diagnosis and Therapy

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