Enhanced IL‐4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy

Pala, Pietro; Bjarnason, Ragnar; Sigurbergsson, Fridrik; Metcalfe, Chris; Sigurs, Nele; Openshaw, Peter

doi:10.1183/09031936.02.00249902

Cited by 70 publications

(58 citation statements)

References 23 publications

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“…Many reports have shown that AB due to RSV may be associated with a Th2-lymphocyte response (4,5,12,13). IL-4 production during AB could be induced by RSV infection and could be associated with the development of lower airway tract disease in infancy.…”

mentioning

confidence: 99%

Th-1 and Th-2 cytokine production in infants with virus-associated wheezing

Pitrez

Jones

Andrade

et al. 2005

Braz J Med Biol Res

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Wheezing associated with respiratory viral infections in infancy is very common and results in high morbidity worldwide. The Th1/Th2 pattern of immune response in these patients remains unclear and previous studies have shown controversial results. The aim of the present study was to compare the type of Th1/Th2 cytokine response between infants with acute bronchiolitis, recurrent wheezing and upper respiratory infections from a developing country. Infants younger than 2 years of age admitted to Hospital São Lucas, Porto Alegre, RS, Brazil, between May and November 2001, with an acute episode of wheezing associated with viral respiratory infection were selected. Subjects with upper respiratory infections from the emergency department were selected for the control group. Interferon-γ (IFN-γ) and interleukin-4 (IL-4) levels from nasal aspirates were determined by ELISA from peripheral mononuclear cell cultures. Twenty-nine subjects with acute bronchiolitis, 18 with recurrent wheezing and 15 with upper respiratory infections were enrolled. There were no differences in family history of atopy or parental smoking between groups. Oxygen requirement was similar for the acute bronchiolitis and recurrent wheezing groups. The percentage of positive tests for the cytokines studied and the IFN-γ/IL-4 ratio was similar for all groups. Comparison of the polarized Th1/Th2 cytokine results for the various groups showed no specific pattern of cytokine production. Infants with wheezing from a developing country do not show any specific predominant pattern of Th1/Th2 cytokine production, suggesting that multiple factors may be involved in the pathogenesis of this illness.

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mentioning

confidence: 99%

Th-1 and Th-2 cytokine production in infants with virus-associated wheezing

Pitrez

Jones

Andrade

et al. 2005

Braz J Med Biol Res

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“…An interesting paper in the previous issue of this journal [25] throws new light on the RSV-reactive airways disease (RAD) link. Children with a history of severe RSV bronchiolitis were found to have higher frequencies of RSVspecific IL-4 producing T-cells in their blood, whereas there was no difference in IFN-c responses.…”

mentioning

confidence: 99%

Respiratory syncytial virus and subsequent asthma: one step closer to unravelling the Gordian knot?

Piedimonte

Simões

2002

Eur Respir J

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“…26 In se ve ral stu di es, it was shown that IL-4, IL-13 and IFN-γ le vels in cre a sed af ter RSV in fec tion. [27][28][29] However no re la ti on was shown bet we en IL-4, IFN-γ le vels and re cur rent whe e zing epi sodes. 30 In our study, IL-13 levels were not dif fe rent in RSV po si ti ve and ne ga ti ve ca ses but IL-4 and IFN-γ le vels we re sig ni fi cantly hig her in the non-RSV gro up.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Wheezing Episodes in Children with Respiratory Syncytial Virus and Non-Respiratory Syncytial Virus Bronchiolitis

Karaman¹,

Gunes²,

Erbayraktar³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : It has be en shown that many chil dren who ex pe ri en ce res pi ra tory syncyti al vi rus (RSV) in fec ti on in in fancy de ve lop re cur rent whe e zing epi so des and ast hma la ter. Viral ro le in pat ho ge ne sis of ast hma is still a de ba te. We ai med to in ves ti ga te the re cur ren ce of whe e zing epi so des, atopy and se rum cyto ki ne le vels in chil dren en co un te red with RSV in fec tion. Ad di ti o nally, we ai med to com pa re the se pa ra me ters in chil dren with non-RSV bronc hi o litis. M Ma at te er ri ia al l a an nd d M Me et t h ho od ds s: : The study was con duc ted bet we en Ja nu ary 2006 and No vem ber 2008 in Do kuz Ey lul Uni ver sity hos pi tal. Se venty chil dren aged bet we en 0-36 months who we re diag no sed with acu te bronc hi o li tis for the first ti me we re rec ru i ted for the study. Na sop hary ngeal la va ge flu id was analy zed with poly me ra se cha in re ac ti on (PCR) for RSV an ti gen in all pa ti ents. Se rum im mu nog lo bu lin E, to tal eo si nop hil co unt, in ter le u kin (IL)-4, IL-13 and γ-in terfe ron (IFN-γ) le vels we re ob ta i ned at the last exa mi na ti on of the pa ti ents af ter a fol low up pe riod of 1-3 ye ars. R Re e s su ul lt ts s: : Re cur ren ce of a whe e zing epi so de was ob ser ved in 35% and 53.3% of the pa ti ents in RSV gro up and non-RSV gro up, res pec ti vely (p= 0.064). Me an se rum IFN-γ and IL-4 le vels we re de tec ted to be sig ni fi cantly hig her in non-RSV gro up. No sig ni fi cant re la ti on was de tec ted bet we en re cur ren ce of whe e zing epi so des and to tal eo si nop hil co unt, se rum IgE, IL-4, IL-13, and IFN-γ le vels. C Co on nc c l lu u s si i o on n: : No dif fe ren ce co uld be de tec ted bet we en RSV and non-RSV bronc hi o li tis re gar ding sub se qu ent whe e zing epi so des. Alt ho ugh se rum IL-4 and IFN-γ levels we re hig her in non-RSV bronc hi o li tis gro up, no sig ni fi cant cor re la ti on was ob ser ved bet we en the se pa ra me ters and re cur ren ce of whe e zing epi so des. K Ke ey y W Wo or rd ds s: : Asthma; bronchiolitis Ö ÖZ ZE ET T A Am ma aç ç: : Süt çocukluğu döneminde respiratuvar sinsityal virus (RSV) infeksiyonu geçiren çocukların daha sonra hışıltı atakları ve astım geçirdikleri gösterilmiştir. Astımın patogenezinde virüslerin rolü halen tartışmalıdır. RSV infeksiyonu ile karşılaşan çocuklarda hışıltı ataklarının tekrarlamasını, atopi ve serum sitokin düzeylerini araştırmayı ,ayrıca bu parametreleri RSV-dışı bronşioliti olan çocukların sonuçları ile karşılaştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma Ocak 2006 ile Kasım 2008 arasında Dokuz Eylül Üniversitesi Hastanesinde gerçekleştirildi. İlk kez akut bronşiolit tanısı koyulan 0-36 ay yaş aralığında 70 çocuk çalışmaya alındı. Tüm hastalarda nazofarenjiyal lavaj sıvısı RSV antijeni bakımından polimeraz zincir reaksiyonu (PCR) ile incelendi. Bir ila üç yıllık takip süresinden sonra hastaların son muayenelerinde serum immunoglobuli...

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Enhanced IL‐4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy

Cited by 70 publications

References 23 publications

Th-1 and Th-2 cytokine production in infants with virus-associated wheezing

Th-1 and Th-2 cytokine production in infants with virus-associated wheezing

Respiratory syncytial virus and subsequent asthma: one step closer to unravelling the Gordian knot?

Recurrence of Wheezing Episodes in Children with Respiratory Syncytial Virus and Non-Respiratory Syncytial Virus Bronchiolitis

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