Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage

Jasiewicz, Małgorzata; Knapp,; Waszkiewicz, Ewa; Ptaszyńska‐Kopczyńska, Katarzyna; Szpakowicz, Anna; Sobkowicz, Bożena; Musiał, Włodzimierz J.; Kamiński, Karol

doi:10.1016/j.cyto.2015.06.018

Cited by 40 publications

(26 citation statements)

References 31 publications

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“…Our research focused on the examination of interleukin (IL-6) and C-reactive protein (CRP). IL-6, an inflammatory and fibrogenic cytokine, is thought to play an important role in the development of lung disease (Jasiewicz et al, 2015). Recent studies demonstrated that IL-6 is marked increased in CS exposed animals .…”

Section: Discussionmentioning

confidence: 99%

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

Zhao

Yang

Shang

et al. 2018

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

Zhao

Yang

Shang

et al. 2018

Journal of Ethnopharmacology

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“…In detail, IL-6 classic signaling is implicated in the synthesis of acute-phase proteins in hepatocyte, which have anti-inflammatory properties and are indispensable for immune defense (52). Whereas, in various inflammation and autoimmune diseases, as well as inflammation-associated cancer, IL-6 trans-signaling is pro-inflammatory and blockade of it is sufficient to alleviate the inflammatory reaction (53–61). But the controversy is existed.…”

Section: Classic and Trans-signaling Pathway Of Il-6mentioning

confidence: 99%

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

2017

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Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.

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“…Recently, Jasiewicz et al proved that IL-6 trans-signalling is enhanced in pulmonary hypertension and its levels are associated with clinical indicators of disease severity [36]. Data published by Spoto et al showed that high-serum IL-6 is associated with a history of CVD and predicts incident CV events in patients diagnosed with stages II–V of CKD progression [37].…”

Section: Discussionmentioning

confidence: 99%

The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease

et al. 2019

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PurposeIndoxyl sulfate (IS) is one of the most potent uremic toxins involved in chronic kidney disease (CKD) progression, induction of inflammation, oxidative stress, and cardiovascular diseases occurrence. It is proved that hypertension is a common CVD complication and a major death risk factor as well as contributes for decline in a renal function. The aim of our study was to investigate how implementing of antihypertensive therapy impact IS concentrations and the associations between IS and markers of renal function, inflammation and oxidative stress.MethodsStudy was conducted on 50 patients diagnosed with CKD and hypertension, divided into three groups: without hypotensive therapy (CKD-NONE), hypotensive monotherapy (CKD-MONO), and hypotensive polypharmacotherapy (CKD-POLI), and 18 healthy volunteers. The markers of inflammation [interleukin-6, tumor necrosis factor-alpha (TNF-α), high-sensitive C-reactive protein (hs-CRP), neopterin, ferritin], oxidative status [superoxide dismutase (Cu/Zn-SOD), antibodies against oxidized low-density lipoprotein (oxLDL-abs)], and selectins were determinate using immunoenzymatic methods. IS levels were assayed using high-performance liquid chromatography and other parameters were analysed using routine laboratory techniques. Then cross-sectional analysis was performed.ResultsElevated levels of IS, indicators of kidney function, markers of inflammation and blood pressure values were observed in each CKD subgroups. There was no effect of antihypertensive therapy on IS levels between studied groups, as well as there was no clear relationship between IS and blood pressure values in each studied group. The positive associations between IS and Cu/Zn SOD, neopterin, hs-CRP, creatinine and neutrophils/lymphocytes ratio were observed in CKD-NONE and CKD-POLI subgroups. Additionally, in CKD-POLI group IS positively correlated with TNF-α, ferritin and neutrophils. In CKD-MONO group, IS was positively related to oxLDL-abs, neopterin, E-selectin and creatinine, whereas it was inversely associated with hs-CRP.ConclusionsOur study showed for the first time that the antihypertensive therapy has no impact on IS levels in CKD patients with hypertension. However, the introduction of the antihypertensive therapy modified the dependencies between IS and the studied markers of kidney function, inflammation, oxidative stress and hematological parameters that are crucial for mortality and morbidity amongst the CKD patients with hypertension.Electronic supplementary materialThe online version of this article (10.1007/s11255-018-02064-3) contains supplementary material, which is available to authorized users.

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Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage

Cited by 40 publications

References 31 publications

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease

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