The impurity-limited resistance in quasi-one dimensional nanowires is studied by the Nonequilibrium Green function simulations and the Lippmann-Schwinger scattering theory under various spatial configurations of localized impurities. It is shown explicitly that both phase interference and phase randomization simultaneously play a crucial role in determining the impurity-limited resistance even under the fully coherent circumstances. Consequently, the ensemble average resistance of multiple impurities under the uniform configuration of impurities becomes very close to the series resistance due to single-impurity at room temperature and, thus, each impurity could be regarded as an independent scattering center.