Enhanced In Vitro Skin Deposition Properties of Retinyl Palmitate through Its Stabilization by Pectin

Suh, Dong‐Churl; Kim, Yeongseok; Kim, Hyeongmin; Ro, Jieun; Cho, Seong-Wan; Yun, Gyiae; Choi, Sung-Up; Lee, Jaehwi

doi:10.4062/biomolther.2013.094

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…The reason for the consideration of polysaccharides as stabilizers for RP was their usefulness in being formulated into cosmetic formulations such as gels, creams, and packs. In addition, we also confirmed the stabilizing action of pectin can improve the skin penetration and distribution characteristics of RP in a rat skin model [ 9 ]. Based on our previous investigation, we could further anticipate that microor nano-particulated RP can maximize the stabilizing effect of pectin on RP.…”

Section: Introductionsupporting

confidence: 64%

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport

Kim

et al. 2015

Korean J Physiol Pharmacol

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Retinyl palmitate (RP)-loaded pectinate micro- and nano-particles (PMP and PNP) were designed for stabilization of RP that is widely used as an anti-wrinkle agent in anti-aging cosmeceuticals. PMP/PNP were prepared with an ionotropic gelation method, and anti-oxidative activity of the particles was measured with a DPPH assay. The stability of RP in the particles along with pectin gel and ethanolic solution was then evaluated. In vitro release and skin permeation studies were performed using Franz diffusion cells. Distribution of RP in each skin tissue (stratum corneum, epidermis, and dermis) was also determined. PMP and PNP could be prepared with mean particle size diameters of 593~843 μm (PMP) and 530 nm (i.e., 0.53 μm, PNP). Anti-oxidative activity of PNP was greater than PMP due largely to larger surface area available for PNP. The stability of RP in PMP and PNP was similar but much greater than RP in pectin bulk gels and ethanolic solution. PMP and PNP showed the abilities to constantly release RP and it could be permeated across the model artificial membrane and rat whole skin. RP was serially deposited throughout the skin layers. This study implies RP loaded PMP and PNP are expected to be advantageous for improved anti-wrinkle effects.

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Section: Introductionsupporting

confidence: 64%

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport

Kim

et al. 2015

Korean J Physiol Pharmacol

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“…Pectin has been used to stabilize RPalm, leading to its improvement of skin permeation and deposition. 43 In this study, retinoids were combined with glycerol, ethanol and water to prepare the therapeutic formulation, showing good efficacies. However, other components need to be next tested in retinoid formulations as possibly better stabilizing adjuvant and skin penetration agent, such as collagen, alginate, HA, and chitosan.…”

Section: Discussionmentioning

confidence: 99%

“…Skin permeation and distribution of retinoids are essential for their therapeutic performance. Pectin has been used to stabilize RPalm, leading to its improvement of skin permeation and deposition 43 . In this study, retinoids were combined with glycerol, ethanol and water to prepare the therapeutic formulation, showing good efficacies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of five retinoids for anti‐photoaging therapy: Evaluation of anti‐inflammatory and anti‐oxidative activities in vitro and therapeutic efficacy in vivo

Shu,

Jiang,

et al. 2023

Photochem & Photobiology

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Over the past decades, increasing evidences have demonstrated that five retinoids, including retinol (ROL), retinol acetate (RAc), retinol propionate (RP), retinol palmitate (RPalm), and hydroxypinacolone retinoate (HPR), can be potential therapeutic agents for skin photoaging. However, therapeutic efficacies and biosafety have never been compared to these compounds. This study aimed to determine the optimal retinoid type(s) for anti‐photoaging therapy both in vitro and in vivo. Our data demonstrated that four retinoids (RPalm, RP, HPR and ROL) but not RAc were effective for anti‐photoaging treatment at 5 μg/mL in vitro, with action mechanisms associated with antioxidative, anti‐inflammatory and anti‐skin ECM degradation activities. Notably, both RPalm and RP appeared superior to HPR and ROL for those activities. Importantly, both RPalm and RP were shown to be optimal for anti‐photoaging therapy when topically applied at 5 mg/kg in a UVB‐induced mice model of photoaging, which is consistent with their high anti‐photoaging activities in vitro. Additionally, topical application of these five retinoids showed satisfactory biosafety without causing significant apoptosis in animal organs, although RP application led to a slight decline in animal body weights. Collectively, these data have laid a good foundation for the next development of the clinical application of these retinoids for skin healthcare.

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“…Nevertheless, RP is a very popular cosmetic ingredient and there is ongoing research to improve its stability and efficacy through various formulation approaches, including nanoformulations [54, [121][122][123][124][125][126][127][128], microencapsulation [124,129], or combination with other ingredients such as pectin [124,130]. Most of the developed formulations have been evaluated by various in vitro or ex vivo tests, including release and skin permeation studies [54, 121,124,125,127,128,131], skin irritation test [123], in vitro safety profile and in vitro antioxidant activity [126].…”

Section: Retinyl Palmitatementioning

confidence: 99%

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Milosheska¹,

Roškar

2022

Adv Ther

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Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

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Enhanced In Vitro Skin Deposition Properties of Retinyl Palmitate through Its Stabilization by Pectin

Cited by 11 publications

References 20 publications

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport

Comparison of five retinoids for anti‐photoaging therapy: Evaluation of anti‐inflammatory and anti‐oxidative activities in vitro and therapeutic efficacy in vivo

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

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