Enhanced in vivo wound healing efficacy and excellent antibacterial, antifungal, antioxidant and anticancer activities via AgNPs@PCS

Zare-Bidaki, Majid; Ghasempour, Alireza; Mohammadparast-Tabas, Pouria; Ghoreishi, Seyedeh Masoumeh; Alamzadeh, Esmat; Javanshir, Reyhane; Le, Binh Nguyen; Barakchi, Mahsa; Fattahi, Mehdi; Mortazavi-Derazkola, Sobhan

doi:10.1016/j.arabjc.2023.105194

Cited by 36 publications

(5 citation statements)

References 70 publications

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“…Therefore, it can be applied that through the use of nanosilver, the wound healing process is damaged and thus the skin ends up with the exact appearance of the previous damage. [108] The same properties were confirmed by Tian et al, whose research confirmed the reduction of fibrogenic cytokines that initiate inflammation in the wound, [109] or Mensah et al, who combined Ag NPs into one material with eggshell membrane, the developed material, due to its properties, can be used as a potential skin dressing used in the treatment of wounds. [110] Another example of a nanocomposite that has a place as a potential wound-healing accelerator is chitosan and Ag NPs (Chi/Ag-NP).…”

Section: Application In Wound Treatmentmentioning

confidence: 70%

“…prepared Vaseline ointment containing Ag NPs synthesized using Petroselinum crispa seed extract and examined their effect on the burn wound, showing that Ag NPs occur on specific processes of granulation and epithelialization. Therefore, it can be applied that through the use of nanosilver, the wound healing process is damaged and thus the skin ends up with the exact appearance of the previous damage [108] . The same properties were confirmed by Tian et al., whose research confirmed the reduction of fibrogenic cytokines that initiate inflammation in the wound, [109] or Mensah et al., who combined Ag NPs into one material with eggshell membrane, the developed material, due to its properties, can be used as a potential skin dressing used in the treatment of wounds [110] .…”

Section: Properties Of Ag Nps and Au Npsmentioning

confidence: 99%

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Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Kowalska,

Adamska,

Grobelna

2024

ChemMedChem

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Nanoparticles (NPs) of noble metals such as silver (Ag NPs) or gold (Au NPs) draw the attention of scientists looking for new compounds to use in medical applications. Scientists have used metal NPs because of their easy preparation, biocompatibility, ability to influence the shape and size or modification, and surface functionalization. However, to fully use their capabilities, both the benefits and their potential threats should be considered. One possibility to reduce the potential threat and thus prevent the extinction of their properties resulting from the agglomeration, they are covered with a neutral material, thus obtaining core‐shell nanostructures that can be further modified and functionalized depending on the subsequent application. In this review, we focus on discussing the properties and applications of Ag NPs and Au NPs in the medical field such as the treatment of various diseases, drug carriers, diagnostics, and many others. In addition, the following review also discusses the use and potential applications of Ag@SiO2 and Au@SiO2 core‐shell nanostructures, which can be used in cancer therapy and diagnosis, treatment of infections, or tissue engineering.

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Section: Application In Wound Treatmentmentioning

confidence: 70%

Section: Properties Of Ag Nps and Au Npsmentioning

confidence: 99%

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Kowalska,

Adamska,

Grobelna

2024

ChemMedChem

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“…P. crispum Mill. was found to possess many pharmacological effects, including antioxidant, antibacterial, antifungal, hepatoprotective, antidiabetic, analgesic, antispasmodic, immunosuppressive, and gastroprotective properties [19][20][21][22][23][24][25][26][27][28]. The results of previous studies highlighted the presence of certain phenolic compounds, mainly ferulic acid, gallic acid, and quercetin.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis

Ganea,

Vicaș,

Gligor

et al. 2024

Molecules

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The status of parsley as a well-known folk medicine noted for its nutritional and medicinal properties prompted the exploration of its potential as a functional food and natural remedy. The paper aims to investigate the potential of parsley to enhance muscle function and alleviate psoriasiform dermatitis, eventually establishing it as a natural, well-tolerated alternative with specific benefits for both muscles and skin. This study examines the tolerability of parsley in a cohort of 937 participants by assessing immunoglobulin G (IgG) reactions. The findings reveal high tolerability, as 96.26% of participants experienced no adverse effects. Among the 902 individuals lacking hypersensitivity, 37.02% reported muscle cramps, with a notable 15.02% reduction observed in the subgroup consuming parsley juice. In the subset of 32 subjects with dermatitis, the application of parsley extract ointment led to a significant decrease in dermatological parameters (redness, thickness, scaling). While the control group exhibited improvements, statistical significance was not observed. Notably, four categories of affected area reduction were identified, with scaling demonstrating the most pronounced impact. The results propose that parsley holds promise for favorable tolerability, contributing to the alleviation of muscle cramps and presenting an effective alternative in dermatitis treatment. Nonetheless, sustained validation through long-term studies is imperative to substantiate these preliminary findings.

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“…The different concentrations (3.25-200 mg/ml) of silver nanoparticles prepared from methanol extract of P. crispum seeds (AgNPs@PCS) were examined by MTT assay against MCF-7 cell line. The IC50 value was found to be 200 mg/ml after 24 hours of exposure [73].…”

Section: Anticancer Activitymentioning

confidence: 96%

“…In the in vivo examination, it was observed that the wound closure percentage was higher on the 7 th and 14 th days than in the control group (vaseline) and the wound was completely closed after 21 days. It has been reported that nanoparticles have the potential to be used clinically [73].…”

Section: Wound Healing Activitymentioning

confidence: 99%

Petroselinum Crispum (Mill.) Fuss (Parsley), a Food and Medicinally Important Plant: A Review of Recent Studies Between 2013-2023

Subaş,

Özgen,

Gökkaya

et al. 2024

Ankara Ecz. Fak. Derg.

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Objective: Petroselinum crispum (Mill.) Fuss is a bright green biennial medicinal and aromatic herb that grows almost all over the world. Today, it is one of the most commonly used culinary herbs. In addition to its use as food, it has been shown to possess broad pharmacological activities in several in vivo and in vitro studies. This study aimed to comprehensively summarize the current studies on the traditional use, phytochemical composition, pharmacological activities, clinical studies, toxicity, and drug interactions of parsley. Result and Discussion: According to the literature data, parsley is used as a diuretic, carminative, emmenagogue and for the prevention and treatment of kidney stone formation, the treatment of conditions such as urinary tract infections and stomach disorders. Its phytochemical composition consists of flavonoids, coumarins, phenolic compounds, organic acids, carotenoids, vitamins, minerals, fixed oil, essential oil, and other compounds. Studies on P. crispum have shown that it has a wide range of pharmacological activities, including antioxidant, antibacterial, antifungal, antidiabetic, antihypertensive, antiplatelet, analgesic, antiinflammatory, antihepatotoxic, antinephrotoxic, anticancer, antiurolithiatic, wound healing, antiobesity, estrogenic and neuroprotective effects. This review comprehensively summarizes the scientific data of the last ten years (2013-2023) on P. crispum.

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Enhanced in vivo wound healing efficacy and excellent antibacterial, antifungal, antioxidant and anticancer activities via AgNPs@PCS

Cited by 36 publications

References 70 publications

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis

Petroselinum Crispum (Mill.) Fuss (Parsley), a Food and Medicinally Important Plant: A Review of Recent Studies Between 2013-2023

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