Enhanced Inhibition of Protein Carbohydrate Interactions by Dendritic Multivalent Glycoligands

Abstract

Dendritic glycoligands of numerous sizes and shapes have provided a wealth of information about multivalency effects in the binding and inhibition of carbohydrate binding proteins over the years. Considering the biological roles of many such proteins, inhibition can be a highly valuable goal. Here a number of well-studied proteins have been selected and the effectiveness of the various dendritic ligands is discussed in relation to the nature of the protein target and the relevant multivalency mechanisms.