Enhanced intestinal glucose and alanine transport in cystic fibrosis.

Abstract

The rise in short-circuit current associated with the active transport ofglucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na+-linked nutrient transport is enhanced in cystic fibrosis.

The effect of rapid changes in plasma sugar concentration on the brush‐border potential difference in rat jejunum

“…In this context it is of interest that, when animals are made hypoglycaemic with insulin, sugar uptake across the jejunal brush-border membrane is enhanced, also within minutes (Debnam & Chowrimootoo, 1993) by a mechanism involving a decreased brush-border membrane Cl-conductance. A reduced brush-border permeability to Cl-may also explain the higher jejunal sugar transport in cystic fibrosis (Baxter, Goldhill, Hardcastle, Hardcastle & Taylor, 1990).…”

Status of Fluid and Electrolyte Absorption in Cystic Fibrosis

“…Early reports indicated enhanced Na þ -dependent glucose cotransport (Frase et al 1985). These observations were supported by the subsequent studies showing increased nutrientdependent short circuit currents (Baxter et al , 1989(Baxter et al , 1990aHardcastle et al 1990;Teune et al 1996). It is well known that secretion of electrolyte fluid is severely compromised throughout the intestine including the jejunum and ileum (Berschneider et al 1987(Berschneider et al , 1988Taylor et al 1987Taylor et al , 1988.…”

Methyl 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-4-nitrobenzoate

“…For use of boronic acids as synthetic intermediates, see : Hall (2005); for their use as sensors in the alcoholic beverage industry, see : Wiskur & Anslyn (2001) and as saccharide sensors, see: Baxter et al (1990); Fedorak et al (1989); Yamamoto et al (1990); Yasuda et al (1990). For a review on borolectins, see : Yang et al (2002: Yang et al ( , 2004.…”

“…However, they have found wider applications more recently as sensors of 'gallate-like′ compounds in the alcoholic beverage industry (Wiskur & Anslyn, 2001), in the development of saccharide sensors (in vivo at neutral pH in aqueous environment) (Baxter et al, 1990;Fedorak et al, 1989;Yamamoto et al, 1990;Yasuda et al, 1990), boronolectins (Yang et al, 2002(Yang et al, , 2004, as protease (Fevig et al, 1996;Kettner et al, 1990;Prusoff et al, 1993), glycosidase (Johnson & Houston, 2002) and proteasome inhibitors (Adams et al, 1998).…”