Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat

Intra-amygdaloid infusion of Ginkgo biloba leaf extract (EGb761) facilitates fear-potentiated startle in rats

“…It has been found to increase cerebral blood flow (Krieglstein et al 1986), and the flavonoid constituents of EGb761 are known to possess free-radical scavenging properties (Clostre 2000). These mechanisms concern the ability of EGb761 to serve as a protective agent to protect against oxidative stress and prevent mitochondrial aging (Millan et al 1998;Topic et al 2002b;Smith and Luo 2003). Thus, it is providing a buffer against rapid age-related decline in mental function.…”

Herbal medicine Davaie Loban in mild to moderate Alzheimer’s disease: A 12-week randomized double-blind placebo-controlled clinical trial

“…The authors reported that Zingicomb might also facilitate spatial learning in older rats and reduces oxidative stress in the brain after chronic administration. 34 P. nigrum has also been implicated in animal studies to decrease oxidative stress in the brain tissue and improving neurodegenerative condition. 35 The above mentioned studies indicate the positive effect of each of the herbal medicines used in DL on memory.…”

Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders

“…The mixed herbal preparations that have antidementia effects on animal models are listed: BR-16A (Mentat) (Faruqi et al, 1995;Handu and Bhargava, 1997), Bu-Zhong-Yi-Qi-Tang (Shih et al, 2000), Choto-san (Mizushima et al, 2003;Watanabe et al, 2003;Yuzurihara et al, 1999), DX-9386 (Nishiyama et al, 1994a(Nishiyama et al, , 1994bSmriga et al, 1995;Zhang et al, 1994), Liuwei-Dihuang-Wan (Hirokawa et al, 1994;Hsieh et al, 2003;Wei, 2000), Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) (Egashira et al, 2003), Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) (Xu et al, 2000), S-113M (Nishiyama et al, 1995b(Nishiyama et al, , 1996, Shosaikoto (Amagaya et al, 1990), Yi-Zhi-Fang (Shan et al, 2002), and Zingicomb (Topic et al, 2002a(Topic et al, , 2002b.…”