Enhanced Membrane-tethered Mucin 3 (MUC3) Expression by a Tetrameric Branched Peptide with a Conserved TFLK Motif Inhibits Bacteria Adherence*

Pan, Qiong; Yin, Tian; Li, Xiaohuan; Ye, Jun; Liu, Yun; Song, Lili; Yang, Yongtao; Zhu, Rong; He, Yonghong; Chen, Lei; Chen, Wensheng; Mao, Xuhu; Peng, Zhihong; Wang, Rongquan

doi:10.1074/jbc.m112.408245

Cited by 21 publications

(15 citation statements)

References 35 publications

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“…Pan et al expressed synthetic tetrameric-branched peptide that enhanced the expression of Mucin 3 (25). They found that Mucin 3 interacted with EPEC and EHEC and reduced their binding to epithelial cells.…”

Section: Enteropathogenic E Coli (Epec)mentioning

confidence: 99%

Recent advances in adherence and invasion of pathogenic Escherichia coli

Kalita¹,

Hu²,

Torres

2014

Current Opinion in Infectious Diseases

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Purpose of review Colonization of the host epithelia by pathogenic Escherichia coli is influenced by the ability of the bacteria to interact with host surfaces. Because the initial step of an E. coli infection is to adhere, invade, and persist within host cells, some strategies used by intestinal and extra-intestinal E. coli to infect host cell are presented. Recent findings This review highlights recent progress understanding how extra-intestinal pathogenic E. coli strains express specific adhesins/invasins that allow colonization of the urinary tract or the meninges, while intestinal E. coli strains are able to colonize different regions of the intestinal tract using other specialized adhesins/invasins. Finally, evaluation of, different diets and environmental conditions regulating the colonization of these pathogens is discussed. Summary Discovery of new interactions between pathogenic E. coli and the host epithelial cells unravels the need of more mechanistic studies that can provide new clues in how to combat these infections.

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Section: Enteropathogenic E Coli (Epec)mentioning

confidence: 99%

Recent advances in adherence and invasion of pathogenic Escherichia coli

Kalita¹,

Hu²,

Torres

2014

Current Opinion in Infectious Diseases

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“…The pGL3-Basic vector containing the miR-200b-a-429 promoter (Ϫ158 to ϩ19 bp) and two E-box sites (CACCTG) served as a wild-type construct for the generation of the miR-200b-a-429-Luc construct, which harbors mutations in the two E-box sites (CACCGG) via PCRbased site-directed mutagenesis. Transfection of the luciferase reporters with different miR-200 promoters and luciferase assays were performed as described in our previous report (19).…”

Section: Methodsmentioning

confidence: 99%

MicroRNA-200 (miR-200) Cluster Regulation by Achaete Scute-like 2 (Ascl2)

Yin

Pan

Shang

et al. 2014

Journal of Biological Chemistry

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“…It is part of a tandem duplication involving MUC3A, and MUC3B is expressed exclusively in the small intestine and colon (Pratt et al 2000;Kyo et al 2001). Variants of MUC3A have been associated with inflammatory bowel disease, and up-regulation of MUC3 inhibited adherence of pathogenic E. coli in human intestinal cells (Pan et al 2013). The CHM1 version of MUC3B contains four copies of the tandem repeat.…”

Section: Gene Contentmentioning

confidence: 99%

Single haplotype assembly of the human genome from a hydatidiform mole

et al. 2014

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A complete reference assembly is essential for accurately interpreting individual genomes and associating variation with phenotypes. While the current human reference genome sequence is of very high quality, gaps and misassemblies remain due to biological and technical complexities. Large repetitive sequences and complex allelic diversity are the two main drivers of assembly error. Although increasing the length of sequence reads and library fragments can improve assembly, even the longest available reads do not resolve all regions. In order to overcome the issue of allelic diversity, we used genomic DNA from an essentially haploid hydatidiform mole, CHM1. We utilized several resources from this DNA including a set of end-sequenced and indexed BAC clones and 1003 Illumina whole-genome shotgun (WGS) sequence coverage. We used the WGS sequence and the GRCh37 reference assembly to create an assembly of the CHM1 genome. We subsequently incorporated 382 finished BAC clone sequences to generate a draft assembly, CHM1_1

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Enhanced Membrane-tethered Mucin 3 (MUC3) Expression by a Tetrameric Branched Peptide with a Conserved TFLK Motif Inhibits Bacteria Adherence*

Cited by 21 publications

References 35 publications

Recent advances in adherence and invasion of pathogenic Escherichia coli

Recent advances in adherence and invasion of pathogenic Escherichia coli

MicroRNA-200 (miR-200) Cluster Regulation by Achaete Scute-like 2 (Ascl2)

Single haplotype assembly of the human genome from a hydatidiform mole

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