Enhanced mindfulness-based stress reduction in episodic migraine: a randomized clinical trial with magnetic resonance imaging outcomes

Seminowicz, David A.; Burrowes, Shana A B; Kearson, Alexandra; Zhang, Jing; Krimmel, Samuel R.; Samawi, Luma; Furman, Andrew J.; Keaser, Michael L.; Gould, Neda F; Magyari, Trish; White, Linda W.; Goloubeva, Olga; Goyal, Madhav; Peterlin, B. Lee; Haythornthwaite, Jennifer A.

doi:10.1097/j.pain.0000000000001860

Cited by 81 publications

(123 citation statements)

References 97 publications

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“…Consequently, a more skilful approach and a new perspective could be utilizing (Ghawadra et al., 2019; Gu et al., 2020), thereby reducing emotional exhaustion and depersonalization. Meanwhile, studies showed that long‐term mindfulness meditation training could thicken the cerebral cortex responsible for attention and comprehensive emotions, shrink the amygdala related to fear emotions and strengthen the function of the insula (Seminowicz et al., 2020; Yuan et al., 2020), which lead the individuals to be more positive and optimistic. These studies proved that the effect of mindfulness on emotional exhaustion from the perspective of neurophysiological mechanism, and depersonalization is the result of emotional exhaustion.…”

Section: Discussionmentioning

confidence: 99%

Mindfulness, emotional intelligence and occupational burnout in intensive care nurses: A mediating effect model

Xie

Zeng

et al. 2020

J Nurs Manag

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Aim(s) To construct structural equation models to test the mediating role of emotional intelligence in the relationship between mindfulness and occupational burnout. Background Reports assessing the relationships among mindfulness, emotional intelligence and burnout, specifically in ICU nurses, are scarce. Methods This was a descriptive, correlational, cross‐sectional research design with 883 ICU nurses enrolled by convenience sampling from 29 ICUs in seven tertiary hospitals in urban areas of Chengdu, China. Mediation analysis was performed by structural equation modelling. Indirect effects were evaluated through bootstrapping. Results The associations among mindfulness, emotional intelligence, emotional exhaustion, depersonalization and personal accomplishment were all significant (p < .001). In the mediation models, emotional intelligence partially mediates the relationships between mindfulness and emotional exhaustion (indirect effect 0.118, p = .006; direct effect −0.374, p = .010; total effect −0.492, p = .011) and between mindfulness and depersonalization (indirect effect −0.182, p = .006; direct effect −0.452, p = .015; total effect −0.633, p = .018). Emotional intelligence plays a total mediating role between mindfulness and personal accomplishment (indirect effect 0.293, p = .004; direct effect 0.119, p = .053). Conclusions The results suggest that nursing manager could implement mindfulness training to improve occupational burnout in ICU nurses. Implications for Nursing Management Nursing managers could help create a more favourable working environment by providing mindfulness training. Such mindfulness training could help improve nursing quality, reduce errors and ensure patient safety, possibly improving patient prognosis and probably satisfaction.

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Section: Discussionmentioning

confidence: 99%

Mindfulness, emotional intelligence and occupational burnout in intensive care nurses: A mediating effect model

Xie

Zeng

et al. 2020

J Nurs Manag

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“…This secondary analysis utilized data from the MRI Outcomes of Mindfulness Meditation for Migraine clinical trial (NCT02133209). 17 Participants were enrolled from June 2014 to February 2017. The primary objective of the clinical trial was to determine the short and long term efficacy of MBSR+ on headache frequency, brain structure and function.…”

Section: Methodsmentioning

confidence: 99%

“…Patients may also have better sleep quality, related to MBSR and or improvement in headaches. This secondary data analysis from our clinical trial 17 assessed enhanced MRSR (MBSR+) as a comprehensive therapy for migraine. We hypothesized that a) compared to SMH, patients randomized to MBSR+ have greater improvement in sleep quality, anxiety, depression and stress symptoms over time compared to an active control treatment arm, b) baseline sleep quality, anxiety, depression and stress symptoms predict treatment response to MBSR+ and c) sleep quality, anxiety, depression and stress symptoms are mediators of the effect of MBSR+ on treatment response.…”

Section: Introductionmentioning

confidence: 99%

Effects Of Mindfulness On Sleep Quality, Anxiety, Depression and Stress In Migraine

Burrowes

Goloubeva

Stafford

et al. 2020

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Objective: To examine the change over time in sleep quality and psychosocial outcomes from the MRI Outcomes for Mindfulness Meditation Clinical Trial, assess how these mediated treatment response (50% reduction in headache frequency post-intervention) and examine the relationship between baseline values and treatment response. Methods: This is a secondary analysis of a randomized placebo-controlled trial with single masking. Patients were recruited from the community, headache clinics and primary care offices in Baltimore Maryland. Eligible patients were aged 18-65 and met the International Classification of Headache Disorders criteria for episodic migraine (4-14 headache days in 28 days).The trial (primary outcomes previously reported) included 98 episodic migraine patients randomized to either enhanced (MBSR+) or stress management for headache (SMH). Follow-up visits occurred at 10, 20 and 52 weeks post baseline. Intervention groups met separately for two hours weekly for 8 weeks and then biweekly for an additional 8 weeks. MBSR+ had an additional half-day retreat held between weeks 6 and 8. Results: There was a significant improvement in sleep quality from baseline to post-intervention (p=0.0025), in both groups. There were no significant change from baseline or between groups in anxiety, depression and stress. There was also no significant association between baseline scores and treatment response. Mediation analysis showed a significant indirect effect for sleep, anxiety, stress, and depression on treatment response, ranging from 6-8%. Conclusions: The findings indicate that in episodic migraine, treatment response to MBSR+ compared to SMH was mediated by small, but significant improvements in sleep, anxiety, depression and stress.

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“…Participants were recruited as part of two larger studies acquiring clinical, behavioral, and MRI data to examine biomarkers of chronic daily headache (patients with CM, Stanford University) and mindfulness based stress reduction for migraine (patients with EM, University of Maryland, Baltimore and Johns Hopkins University) 27 . Prior publications including these data 27,28 did not investigate amygdala structure and/or function between EM and CM in relation to headache and cognitive-affective measures. Patients were eligible for the current study if they were at least 18 years of age and met the diagnostic criteria for EM or CM with or without aura for at least three months according to the International Classification of Headache Disorders (ICHD)-3 1 , as determined by a physician.…”

Section: Methodsmentioning

confidence: 99%

Increased amygdala volume and functional connectivity with cognitive control networks in chronic migraine

DeSouza

Krimmel

Sanjanwala

et al. 2020

Preprint

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Objective: To characterize the role of the amygdala in episodic (EM) and chronic (CM) migraine, we evaluated amygdala volumes, functional connectivity (FC), and associations with clinical and affective measures. Methods: Eighty-eight patients (44 with EM and 44 age- and sex-matched patients with CM) completed anatomical and resting-state functional MRI scans. Amygdala volumes and resting-state FC to three core large-scale cognitive control networks (default mode (DMN), salience (SN), central executive (CEN)) were compared between groups. Associations between amygdala volume and FC, measures of headache severity (frequency and intensity), and cognitive-affective measures (depression, anxiety, pain catastrophizing) were evaluated. Results: Compared to EM, patients with CM had larger amygdala volume bilaterally. Headache frequency and intensity were associated with increased left and right amygdala volume, and depression was associated with increased right amygdala volume. Patients with CM also demonstrated increased left amygdala FC with the DMN, which across patients was related to headache frequency. Left amygdala FC to the SN was correlated with headache intensity while right amygdala FC to the CEN was correlated with pain catastrophizing. Conclusion: Our findings reveal increased amygdala volume and FC with large-scale neurocognitive networks in patients with CM compared to EM. Aberrant amygdala volume and FC measures were associated with increased migraine severity, depression, and pain catastrophizing, pointing to a link between emotion and pain in migraine. Our findings provide novel insights into amygdala involvement in chronic migraine and may inform future interventions aimed at preventing the progression of both headache and its negative cognitive-affective symptoms.

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Enhanced mindfulness-based stress reduction in episodic migraine: a randomized clinical trial with magnetic resonance imaging outcomes

Cited by 81 publications

References 97 publications

Mindfulness, emotional intelligence and occupational burnout in intensive care nurses: A mediating effect model

Mindfulness, emotional intelligence and occupational burnout in intensive care nurses: A mediating effect model

Effects Of Mindfulness On Sleep Quality, Anxiety, Depression and Stress In Migraine

Increased amygdala volume and functional connectivity with cognitive control networks in chronic migraine

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