This paper presents a comparative analysis of interior permanent magnet synchronous motor (IPMSM) drives powered by symmetrical and asymmetrical cascaded H-bridge multilevel inverters. The asymmetric topology operates using multiple DC sources with different voltage values, generating a voltage waveform with more output voltage levels than its traditional counterpart, all while maintaining the same hardware configuration. The main goal is to demonstrate that asymmetrical multilevel inverters are a promising option for improving the performance of electric drives while maintaining cost-efficiency and reliability. The proposed comparison is conducted through simulations in the MATLAB/Simulink R2024a environment, which allows an in-depth analysis of the dynamic performance of the electric drive. Additionally, the variation of the DC link input power of each H-bridge and the Total Harmonic Distortion (THD) of the voltage and current of the output of the converters were studied for different operating conditions in both cases. The obtained results were confirmed through real-time validation, demonstrating the applicability of electric drives powered by asymmetric converters and the advantages, in terms of efficiency, harmonic content and dynamic performance, in certain conditions of operation in terms of speed and applied load.