Enhanced Neuroprotective Effects of Combination Therapy with Bone Marrow-Derived Mesenchymal Stem Cells and &lt;b&gt;&lt;i&gt;Ginkgo biloba&lt;/i&gt;&lt;/b&gt; Extract (EGb761) in a Rat Model of Experimental Autoimmune Encephalomyelitis

Hao, Fei; Li, Aiping; Yu, Huan; Liu, Meichen; Wang, Yachen; Liu, Jing; Liang, Zhanhua

doi:10.1159/000437429

Cited by 11 publications

(4 citation statements)

References 51 publications

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“…Combination therapy of EGb 761 with bone-marrow-derived mesenchymal stem cells (BMSCs) has shown a synergistic effect in animals with autoimmune encephalomyelitis. The therapeutic mechanism involves the inhibition of pro-inflammatory cytokines, demyelination, and protection axons and neurons [ 142 ]. Other studies have documented that GA prevents p-Tau deposition and thus protects cells from toxicity associated with Tau hyperphosphorylation.…”

Section: Ginkgo Biloba Extract (Egb) For Neuroprotection and Potentia...mentioning

confidence: 99%

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Akanchise

Angelova

2023

Pharmaceutics

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Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) and long-term illness consequences. They may be associated with inflammatory processes due to cellular oxidative stress and an imbalanced antioxidant system. The ability of phytochemicals with antioxidant and anti-inflammatory activities, such as Ginkgo biloba, to alleviate neurological complications and brain tissue damage has attracted strong ongoing interest in the neurotherapeutic management of long COVID. Ginkgo biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobalide, quercetin, ginkgolides A–C, kaempferol, isorhamnetin, and luteolin. They have various pharmacological and medicinal effects, including memory and cognitive improvement. Ginkgo biloba, through its anti-apoptotic, antioxidant, and anti-inflammatory activities, impacts cognitive function and other illness conditions like those in long COVID. While preclinical research on the antioxidant therapies for neuroprotection has shown promising results, clinical translation remains slow due to several challenges (e.g., low drug bioavailability, limited half-life, instability, restricted delivery to target tissues, and poor antioxidant capacity). This review emphasizes the advantages of nanotherapies using nanoparticle drug delivery approaches to overcome these challenges. Various experimental techniques shed light on the molecular mechanisms underlying the oxidative stress response in the nervous system and help comprehend the pathophysiology of the neurological sequelae of SARS-CoV-2 infection. To develop novel therapeutic agents and drug delivery systems, several methods for mimicking oxidative stress conditions have been used (e.g., lipid peroxidation products, mitochondrial respiratory chain inhibitors, and models of ischemic brain damage). We hypothesize the beneficial effects of EGb in the neurotherapeutic management of long-term COVID-19 symptoms, evaluated using either in vitro cellular or in vivo animal models of oxidative stress.

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Section: Ginkgo Biloba Extract (Egb) For Neuroprotection and Potentia...mentioning

confidence: 99%

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Akanchise

Angelova

2023

Pharmaceutics

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“…This study also noted the activity of SOD and myeloperoxidase (MPO) ( Yang et al, 2013 ). Hao et al (2016) demonstrated the neuroprotective effect of EGb 761 when co-administered with bone marrow derived mesenchymal stem cells (BMSCs) in encephalomyelitis (EAE). Consequently, combination therapy with BMSCs and EGb 761 showed an synergistic effect in animals with experimental autoimmune encephalomyelitis through inhibition of pro-inflammatory cytokines, demyelination and protection of axons and neurons.…”

Section: The Use Of G Biloba In the Treatment And Prevention Of Admentioning

confidence: 99%

The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease

et al. 2021

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Alzheimer’s disease, a neurodegenerative disease, is one of the most common causes of dementia if elderly people worldwide. Alzheimer’s disease leads to the alienation of individuals and their exclusion from social and professional life. It is characterized mainly by the degradation of memory and disorientation, which occurs as a result of the loss of neuronal structure and function in different brain areas. In recent years, more and more attention has been paid to use in the treatment of natural bioactive compounds that will be effective in neurodegenerative diseases, including Alzheimer’s disease. G. biloba L. and its most frequently used standardized extract (EGb 761), have been used for many years in supportive therapy and in the prevention of cognitive disorders. The paper presents an overview of reports on the pathogenesis of Alzheimer’s disease, as well as a summary of the properties of G. biloba extract and its effects on the possible pathogenesis of the disease. By exploring more about the pathogenesis of the disease and the benefits of G. biloba extract for patients with Alzheimer’s disease, it will be possible to create an individualized therapeutic protocol to optimize the treatment.

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“…Song et al revealed the protective effects of Ginkgo biloba extract Ginkgolide B against acute SCI in rats, which may be related to the JAK/STAT signaling pathway [13]. Current reports have focused on the effects of Ginkgo biloba extracts on neuronal apoptosis and their neuroprotective effects after SCI [14,15]. However, whether Ginkgo biloba extracts inhibit spinal cord inflammation after secondary injury while simultaneously exerting neuroprotection after early decompression has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ginkgo biloba on Early Decompression after Spinal Cord Injury

Guo

Wang

Dong³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Spinal cord injury (SCI) is a severe trauma of the central nervous system characterized by high disability and high mortality. Clinical progress has been achieved in understanding the pathological mechanism of SCI and its early treatment, but the results are unsatisfactory. In China, increasing attention has been paid to the role of traditional Chinese medicine in the treatment of SCI. In particular, extracts from the leaves of Ginkgo biloba (maidenhair tree), which have been reported to exert anti-inflammatory and antioxidant properties and repair a variety of active cellular damage, have been applied therapeutically for centuries. In this study, we established a rat SCI model to investigate the effects of Ginkgo biloba leaves on decompression at different stages of SCI. The application of Ginkgo biloba leaves during the decompression of SCI at different time points, the neurological recovery of SCI, and the underlying molecular mechanism were explored. The findings provide reliable experimental data that reveal the mechanism of GBI (Ginkgo biloba injection) in the clinical treatment of SCI.

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Enhanced Neuroprotective Effects of Combination Therapy with Bone Marrow-Derived Mesenchymal Stem Cells and <b><i>Ginkgo biloba</i></b> Extract (EGb761) in a Rat Model of Experimental Autoimmune Encephalomyelitis

Cited by 11 publications

References 51 publications

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease

Effects of Ginkgo biloba on Early Decompression after Spinal Cord Injury

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