Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation

Xu, Yang; Wang, Qilong; Feng, Yingshu; Firempong, Caleb Kesse; Zhu, Yuan; Omari‐Siaw, Emmanuel; Yang, Zheng; Pu, Zunqin; Xu, Ximing; Yu, Jiangnan

doi:10.1016/j.jff.2016.10.007

Cited by 57 publications

(27 citation statements)

References 24 publications

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“…As shown in Fig 6, pH values of media had no effect on the in vitro release of Res from Res SMEDDS (P>0 . 05) , which is consistent with release properties of phenol compounds Gingerol-SMEDDS reported by Xu Y et al[37]. However, the cumulative percentages of the Res powder at different pH values were 32.53±1.83 (pH = 1.2), 45.40±1.91 (pH = 6.8) and 50.87±1.87 (pH = 7.4), which was significant difference at the three different pH values (P<0 .…”

Section: Resultssupporting

confidence: 89%

Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion

Tang

Xiang

et al. 2019

PLoS ONE

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The purpose of this study was to improve the solubility of resveratrol (Res) by a self-microemulsifying drug-delivery system (SMEDDS). Through a solubility experiment, the pseudoternary phase diagram and ternary phase diagram were used to optimize the Res SMEDDS formula. The optimum formulation consisted of 5% IPM, 20% PEG400, and 65% Cremophor RH40. The water solubility, stability, in vitro release and antioxidant activity of the Res SMEDDS were characterized. The Res solubility in the SMEDDS was at least 1,000 times compared to that in water. The average droplet size of the microemulsion was 28.00±1.67 nm and uniform distribution. The Res SMEDDS should be stored at low temperature and in the dark to avoid light conditions. Res SMEDDS was able to improve the in vitro release rate of Res, and the in vitro release of Res from Res SMEDDS was significantly faster that of Res powder and unaffected by pH value of media. Antioxidant assays showed that antioxidant activities of Res in Res SMEDDS were unaffected compared to Res powder. Cytotoxicity study indicated that Res SMEDDS at the concentration of less than 100 μM was safe. These results demonstrated the potential use of Res SMEDDS for oral administration of Res.

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Section: Resultssupporting

confidence: 89%

Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion

Tang

Xiang

et al. 2019

PLoS ONE

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“…In another study, (6)-Gingerol-SMEDDS formulation was characterized according to its droplet size, polydispersity index and zeta potential. In this study, similar droplet size and polydispersity index were measured (73.06 ± 0.49 nm and 0.32 ± 0.02 respectively), but zeta potential was measured as -2.45 ± 0.41 (44). Figure 4 shows in vitro release graph of Cisplatin loaded SMEDDS formulation and Cisplatin solution with a concentration of 2 mg/mL.…”

supporting

confidence: 66%

Preparation and Characterization of Self-Microemusifying Drug Delivery System (Smedds) of Cisplatin for Oral Use in Ovarian Cancer Treatment

Akartas¹,

Karasulu²

2020

Acta Poloniae Pharmaceutica - Drug Research

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Cancer is one of the most leading causes of death in the world. Ovarian cancer is the seventh most common cancer in women. Also, it has the highest, mortality rate among female reproductive system cancers (1). According to the American Cancer Society in 2018, 22240 new cases of ovarian cancer will be diagnosed and 14070 women will die of ovarian cancer in the United States (2). The highest incidences are related in Europe, Canada and the United States. The lowest incidences are reported in China and Africa. According to GLOBOCAN 2008 database, the incidence rates are reported as over 11 cases per 100000 in Europe, less than 3 cases per 100000 in Africa and 4-8 cases per 100000 in South American, Asian and Caribbean countries (3). The latest cancer mortality statistics of the World Health Organization (WHO) showed that mortality will increase by approximately 45% until 2030 (4). Ovarian cancer has different risk factors like family history, age, early age menarche, menopause, parity, oral contraceptive use, lactation, obesity, cigarette smoking and alcohol consumption (5-7). Epithelial ovarian cancer is the most common type of ovarian cancer. Early diagnosis increases the chances successful treatment. The pathogenesis of ovarian cancer hasnít been elucidated yet, but ovulation, hormonal factors and inflammations have an important role in it (8, 9). There are two types of ovarian tumors. Type I tumors tend to be less aggressive and slow-growing like low grade malign serous tumors, low grade malign endometrioid carcinoma and mucinous carcinoma. Type II tumors are more aggressive than Type I tumors. They are high grade malign serous carcinoma, carcinosarcoma and undifferentiated carcinoma (10, 11). Ovarian cancer is staged by using the FIGO staging system which has 4 stages. A tumor is limited to the ovary at stage I. During stage II, tumor involves one or both of the ovaries. Pelvic extension and primary peritoneal tumor occurred. At stage III,

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“…Finally, add SS to saturation. The final SSSM was obtained by magnetic stirring at 100 r/min for 10 min, oscillating at 100 r/min for 48 h in a 37 °C hotbed and equilibrated for 24 h [19].…”

Section: Methodsmentioning

confidence: 99%

Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice

et al. 2019

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Background The hypolipidemic effect of phytosterols has been wildely recognized, but its application is limited due to its insolubility in water and low solubility in oil. In this study, β-sitosterol ester with linoleic acids and β-sitosterol self-microemulsions were prepared and their hypolipidemic effects on hyperlipidemia mice were studied. Methods Firstly, the mice were randomly divided into normal group and model group,they were fed with basic diet and high-fat diet for 70 days respectively. After high-fat model mice was successfully established, the model group was further divided into eight groups: HFD (high-fat diet feeding), SELA-TSO(8 ml/kg, SELA:700 mg/kg), TSO (8 ml/kg), SSSM (8 ml/kg,SS:700 mg/kg), NLSM (8 ml/kg), SSHT-TSO (8 ml/kg, SS: 700 mg/kg) and SS-TSO (8 ml/kg, SS: 700 mg/kg) groups, and treated with β-sitosterol ester with linoleic acid, β-sitosterol self-microemulsion, commercial β-sitosterol health tablets and β-sitosterol powder for 35 days, respectively, and blank control groups were established. At the end of the treatment period, the blood lipid level, tissues, cholesterol and lipids in feces of mice in each group were investigated. Statistical and analytical data with SPSS 17.0 Software,statistical significance was set at p * < 0.05 and p ** < 0.01 levels . Results The order of lowering blood lipid effect is listed as: SSSM> SELA-TSO > SSHT-TSO > SS-TSO, which shows that β-sitosterolself-microemulsion have the highest treatment effect among the experimental groups. Conclusions In this study, a new formulation of β-sitosterol was developed, and its hypolipidemic effect was investigated. The results showed that β-sitosterol self-microemulsion has a good blood lipid lowering effect.

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Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation

Cited by 57 publications

References 24 publications

Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion

Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion

Preparation and Characterization of Self-Microemusifying Drug Delivery System (Smedds) of Cisplatin for Oral Use in Ovarian Cancer Treatment

Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice

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