2022
DOI: 10.3390/pharmaceutics14071510
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Enhanced Oral Bioavailability of MT-102, a New Anti-inflammatory Agent, via a Ternary Solid Dispersion Formulation

Abstract: This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly soluble extract of Isatis indigotica and Juglans mandshurica) were prepared using a solvent evaporation method with various drug/excipient ratios. Following that, the effectiveness of various SDs as an oral formulation of MT-102 was investigated using indirubin as a marker component. By forming SDs with hydrophilic polymers, the aqueo… Show more

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Cited by 7 publications
(5 citation statements)
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“…Curcumol, a natural product isolated from the traditional Chinese medicine Rhizoma curcumae , possesses various therapeutic values for many diseases [ 19 ]. However, the low aqueous solubility of curcumol may affect drug absorption in the gastrointestinal tract of animals and further limit the translation of this drug into clinical practice [ 1 , 20 ]. In this case, we explored the dose formulation of curcumol and set up four different formulas for oral administration in rats and followed the pharmacokinetic experiments.…”
Section: Discussionmentioning
confidence: 99%
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“…Curcumol, a natural product isolated from the traditional Chinese medicine Rhizoma curcumae , possesses various therapeutic values for many diseases [ 19 ]. However, the low aqueous solubility of curcumol may affect drug absorption in the gastrointestinal tract of animals and further limit the translation of this drug into clinical practice [ 1 , 20 ]. In this case, we explored the dose formulation of curcumol and set up four different formulas for oral administration in rats and followed the pharmacokinetic experiments.…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, extracts and active components of traditional medicine have become the focus of the pharmaceutical and food industry due to their extensive pharmacological activities and application value. Rhizoma curcumae , a traditional Chinese medicine, has been well-known for its use in alleviating pain, removing blood stasis, and anticoagulation over thousands of years [ 1 ]. The essential oil extract of Rhizoma curcumae has shown good bioactivities in anti-bacterial and anti-inflammatory properties, and has already been approved as a therapeutic remedy for disorders by the National Medical Products Administration (NMPA) of China [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Pharmaceutics 2023, 15, x FOR PEER REVIEW 2 of 15 MT-102 is a natural extract derived from Isatis indigotica and Juglans mandshurica, exhibiting a good anti-inflammatory effect [6]. Given its poor aqueous solubility, MT-102 exhibits low oral bioavailability [6].…”
Section: Introductionmentioning
confidence: 99%
“…Pharmaceutics 2023, 15, x FOR PEER REVIEW 2 of 15 MT-102 is a natural extract derived from Isatis indigotica and Juglans mandshurica, exhibiting a good anti-inflammatory effect [6]. Given its poor aqueous solubility, MT-102 exhibits low oral bioavailability [6]. Thus, effective solubilization of MT-102 is essential for enhancing its oral efficacy.…”
Section: Introductionmentioning
confidence: 99%