Enhanced osteoblast differentiation on scaffolds coated with TIO2 compared to SIO2 and CaP coatings

Processing of highly porous TiO2 bone scaffolds with improved compressive strength

“…14 Recent studies have shown the fabrication of highly porous rutile TiO 2 foams with pore architectural properties well-matched for those required from a bone scaffold and the capacity to promote adhesion, proliferation and differentiation of osteoblasts and human mesenchymal stem cells (hMSC) on the entire scaffold surface in vitro. [15][16][17][18] Compressive strength values of approximately 2.5 MPa were reported for these novel TiO 2 scaffolds at overall porosity of ∼85%, 16 while the compressive strength of trabecular bone is typically 2-12 MPa. 19 Since the scaffold structure is also required to provide mechanical stability for the defect site, the use of these TiO 2 scaffolds in load-bearing environment is somewhat limited as the compressive strength of the highly porous TiO 2 foam structure only reaches the lower limit of strength of human trabecular bone.…”

Enhancing bioactive properties of silk fibroin with diatom particles for bone tissue engineering applications

“…Various materials were proposed for osteoinduction, such as inorganic ceramics, metals and polymers (Liu et al ., ; Tautzenberger et al ., ; Verket et al ., ; Zhang et al, ).…”

Cell growth on pore-graded biomimetic TiO2 bone scaffolds

“…9,10 Architectural features of these scaffolds have been shown to facilitate tissue ingrowth and vascularisation, since they surpass porosity, pore size and mechanical values required for enhanced bone formation. 9,11 Nonetheless, despite the successful imitation of trabecular bone, these scaffolds lack the ability to block soft tissue invasion.…”