Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite

Kobayashi, Takayuki; Nakamura, Satoshi; Yamashita, Kimihiro

doi:10.1002/1097-4636(20011215)57:4<477::aid-jbm1193>3.0.co;2-5

Cited by 225 publications

(159 citation statements)

References 32 publications

Supporting

Mentioning

157

Contrasting

Order By: Relevance

“…Even in wide gaps of 0.2-0.5 mm between the HA and bone, direct bonding bone formation was observed on the negatively charged surfaces at 1 week after implantation. 6 In the vicinity of the positively charged HA surfaces, the formation of bone derived from osteoid tissue entirely occupied the gaps. 7 Within 4 weeks, almost perfect bone reconstruction occurred accompanied with activated osteoblastic cells, with the processes varying according to the charge polarity.…”

Section: Introductionmentioning

confidence: 99%

Numerical osteobonding evaluation of electrically polarized hydroxyapatite ceramics

Nakamura

Kobayashi

Yamashita

2003

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Enhanced osteobonding abilities of electrical polarized hydroxyapatite (HA) ceramics were statistically evaluated by a bone morphometric technique. HA ceramics with an average charge of 3.9 Ccm Ϫ2 were implanted in tibial and femoral diaphyses of New Zealand white rabbits. Estimation of the affinity index, defined as the ratio of the direct bonding length to the HA ceramic length, significantly showed more active osteobonding ability with a negatively charged surface than with a positively charged surface and a nonpolarized HA 1 week after administration. The enhanced osteobonding ability attributed to the stimulated osteoids in the vicinity of the positively charged surface ranked above the nonpolarized surface. Although amounts of the newly formed bone on the HA surfaces increased with implantation period in all of the observation areas, the negatively charged surface was almost covered with bone and had the best index value of 94.0% at 4 weeks. The superior osteobonding activity of the negatively charged surfaces was statistically proven.

show abstract

Section: Introductionmentioning

confidence: 99%

Numerical osteobonding evaluation of electrically polarized hydroxyapatite ceramics

Nakamura

Kobayashi

Yamashita

2003

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Polarization is important in biomaterials, since we have more recently demonstrated by in vitro and in vivo tests that the charged surfaces of electrically polarized hydroxyapatite 9,10 acquired enhanced osteoconductivities. [11][12][13] This study will demonstrate the electrical polarizability and in vitro biocompatibility or chemico-vector effect of gc: Narpsio.…”

Section: -7mentioning

confidence: 93%

Chemico-Vector and Mechanochemico-Vector Properties of Polarized Glass-Ceramic Silicophosphate of Narpsio

聡

正人

恵一

et al. 2006

J. Ceram. Soc. Japan

Self Cite

View full text Add to dashboard Cite

ȹȬɲɻɛदệᇋ‫ك‬ȴɱɁ Narpsio ǽȹɧȻɡȷɐɳ‫ڽ‬ȂɩȳɖȹɧȻɡȷɐɳᣀම ቧ ଉ ɿ͑ʅᓺ͆ଉ , ଉ ଉ ɿᢨ୮෴ʶଉ ଉ ɿ୮ˁ͈গଉ ଉ ኇ̸ٛᲇᔂᲇগક᧯Χቦᄦకકᮾ᳣ཀࢫ101-0062 ኇ̸ȩ٣ͦᨀٚᨀْᖽ۞ 2-3-10 ଉ ଉ ኇᘬগકకકȤࢫ259-1292 প᭔౪झల‫ل‬ʈᬶ 1117Glass-ceramics of Na 2 O-R 2 O 3 -P 2 O 5 -SiO 2 Narpsio consist of a skeleton structure of 12-tetrahedra-membered rings and exhibit a super Na ࢪ conductivity. Glass-ceramic Narpsio was proved to be electrically polarized through highly mobile sodium ions. Narpsio also shows relatively higher solubility in water. Taking into account of the water solubility and the chemical composition, the reactivity of polarized and non-polarized glass-ceramic Narpsio in the stimulated body fluid SBF were investigated in relation to bioactivity. After the 6 days' immersion of SBF, hydroxyapatite microcrystals aggregated semispherically were grown on the glass-ceramic Narpsio surfaces. Although the acceleration effects were under study, the growth rate was recognized to be higher in both of the negatively and positively charged surfaces. In analogy with polarized bioglasses, we confirmed the chemico-vector effects of glass-ceramic Narpsio for biomedical purpose. Additionally, glass-ceramic Narpsio, prepared by the locally biasing crystallization method, showed unreported microstructural changes of surfaces during chemical polishing with water, depending upon the direction of a biasing field. The phenomenon was interpreted as a mechanochemico-vector effect.

show abstract

“…So the effect of piezoelectricity of hydroxyapatite would be cancelled out and seems to be minor compared to that of collagen fibrils. In 2001, however, Dr. K. Yamashita found that the negative charge introduced in hydroxyapatite induced the growth of new bone [37], To study the molecular mechanism how the electromechanical properties of collagen and hydroxyapatite influence on the growth of bone is a challenging subject of future research. The Wolff's law connecting the mechanical stress and the direction of growth of bone is also a good target of research.…”

Section: Piezoelectricity Of Synthetic Polymersmentioning

confidence: 99%

Research on bioelectromechanics for 70 years

Fukada

2016

J Biorheol

View full text Add to dashboard Cite

Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite

Cited by 225 publications

References 32 publications

Numerical osteobonding evaluation of electrically polarized hydroxyapatite ceramics

Numerical osteobonding evaluation of electrically polarized hydroxyapatite ceramics

Chemico-Vector and Mechanochemico-Vector Properties of Polarized Glass-Ceramic Silicophosphate of Narpsio

Research on bioelectromechanics for 70 years

Contact Info

Product

Resources

About