Enhanced osteogenesis properties of titanium implant materials by highly uniform mesoporous thin films of hydroxyapatite and titania intermediate layer

Jalali, Fahimeh; Oveisi, Hamid; Meshkini, Azadeh

doi:10.1007/s10856-020-06450-1

Cited by 9 publications

(6 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This current method provides a sustainable and easily reproducible approach for the surface modification of implants. Previous methods showed that the use of TiO 2 surface as intermediate layer between HA and Ti‐6Al‐4V improves cell adhesion 4,88,89 . The temperature and conditions for the pack cementation in this study allows the formation of TiO 2 and HA network on the Ti‐6A‐4V substrates.…”

Section: Discussionmentioning

confidence: 82%

Hydroxyapatite nano‐pillars on TI‐6Al‐4V: Enhancements in cell spreading and proliferation during cell/surface integration

Osafo,

Etinosa,

Obayemi

et al. 2024

J Biomedical Materials Res

View full text Add to dashboard Cite

Despite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti‐6Al‐4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of biomedical devices into the human body. This paper presents a novel, easy and reproducible method of nanoscale and nanostructured hydroxyapatite (HA) coatings on Ti‐6Al‐4V. The resulting nanoscale coatings/nanostructures are characterized using a combination of Raman spectroscopy, scanning electron microscopy equipped with energy dispersive x‐ray spectroscopy. The nanostructured/nanoscale coatings are shown to enhance the early stages of cell spreading and integration of bone cells (hFOB cells) on Ti‐6Al‐4V surfaces. The improvements include the acceleration of extra‐cellular matrix, cell spreading and proliferation by nanoscale HA structures on the coated surfaces. The implications of the results are discussed for the development of HA nanostructures for the improved osseointegration of Ti‐6Al‐4V in orthopedic and dental applications.

show abstract

Section: Discussionmentioning

confidence: 82%

Hydroxyapatite nano‐pillars on TI‐6Al‐4V: Enhancements in cell spreading and proliferation during cell/surface integration

Osafo,

Etinosa,

Obayemi

et al. 2024

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…In this regard, divalent Co 2+ ions are shifted to octahedral "B" sites, and trivalent Fe 3+ ions are occupied by both tetrahedral "A" and octahedral "B" sub-lattice sites [7] . This is a good indication that the CoFe 2 O 4 nanoparticles have been suitable for a wide variety of technological and medical applications [12][13][14][15] .…”

Section: Introductionmentioning

confidence: 77%

Synthesis Factors Dependence of Magnetic Properties of CoFe2O4 and CoFe2-xGdxO4 Semicrystalline Nanoparticles with desired Morphology through Hydrothermal Procedure

Hosseinzadeh

Oveisi

2022

Preprint

Self Cite

View full text Add to dashboard Cite

In the present study, CoFe2O4 and CoFe2-xGdxO4 nanoparticles were synthesized by the hydrothermal process. The CoFe2O4 nanoparticles were synthesized at different temperatures (70oC, 100oC, 150oC, and 200oC), molar ratio of CoCl2/ FeCl3 (0/2, 0.75/2, 1/2, 1.5/2, and 2/2). Gadolinium-doped cobalt ferrite (CoFe2-xGdxO4) nanoparticles have also been synthesized with Gd/Fe molar ratios of 0.18 and 0.53. The XRD patterns indicate that cobalt ferrite and Gadolinium-doped cobalt ferrite nanoparticles have been successfully synthesized without impurities with a medium degree of crystallinity. The XRD patterns show that by increasing the synthesis temperature from 70oC to 200oC, the size of the nanoparticles decreased from 50.49nm to 32.45nm while the morphology of the nanoparticles also changed from a shapeless and agglomerated state to a spherical shape. The XPS curve illustrated several peaks corresponding to Fe+3, Co+2, and O 1s. The binding energies for Co and Fe were consistent with Fe 2p and Co 2p binding energies for cobalt ferrite nanoparticles. The magnetic saturation value (Ms) increased from 17.253 emu/g to 54.438 emu/g with a rise in the synthesis temperature. The effects of FeCl3/CoCl2 molar ratio on the magnetic properties showed the highest value of Ms (54.438 emu/g) and the coercivity (HC) of 744.56 Oe for a 2/1 molar ratio. The addition of gadolinium to the composition resulted in a reducing of the magnetic properties of nanoparticles; accordingly, the amount of saturated magnetization was reduced to 22.469 emu/g. Another effect of gadolinium dopant in the composition was a change in nanoparticle morphology from spherical to rod shape. The final aim of this study was to investigate the possible utilization of CoFe2O4 and CoFe2-xGdxO4 nanoparticles in medical treatment in the near future.

show abstract

“…Many methods have been developed to decorate Ti-based implant surfaces with bioactive molecules in the past decades: sputter-deposition, electrophoretic deposition, sol-gel coating, and plasma spraying or chemical crosslinking, and so on [ [14] , [15] , [16] , [17] ]. However, traditional surface modification strategies mainly rely on covalent bonding to graft bioactive molecules onto the surfaces of Ti-based implants, which will inevitably impair the active epitopes of the biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation

Sun

Huang

Zhao

et al. 2022

Bioactive Materials

View full text Add to dashboard Cite

Upon the osteoporotic condition, sluggish osteogenesis, excessive bone resorption, and chronic inflammation make the osseointegration of bioinert titanium (Ti) implants with surrounding bone tissues difficult, often lead to prosthesis loosening, bone collapse, and implant failure. In this study, we firstly designed clickable mussel-inspired peptides (DOPA-N3) and grafted them onto the surfaces of Ti materials through robust catechol-TiO 2 coordinative interactions. Then, two dibenzylcyclooctyne (DBCO)-capped bioactive peptides RGD and BMP-2 bioactive domain (BMP-2) were clicked onto the DOPA-N3-coated Ti material surfaces via bio-orthogonal reaction. We characterized the surface morphology and biocompatibility of the Ti substrates and optimized the osteogenic capacity of Ti surfaces through adjusting the ideal ratios of BMP-2/RGD at 3:1. In vitro, the dual-functionalized Ti substrates exhibited excellent promotion on adhesion and osteogenesis of mesenchymal stem cells (MSCs), and conspicuous immunopolarization-regulation to shift macrophages to alternative (M2) phenotypes and inhibit inflammation, as well as enhancement of osseointegration and mechanical stability in osteoporotic rats. In summary, our biomimetic surface modification strategy by bio-orthogonal reaction provided a convenient and feasible method to resolve the bioinertia and clinical complications of Ti-based implants, which was conducive to the long-term success of Ti implants, especially in the osteoporotic or inflammatory conditions.

show abstract

Enhanced osteogenesis properties of titanium implant materials by highly uniform mesoporous thin films of hydroxyapatite and titania intermediate layer

Cited by 9 publications

References 77 publications

Hydroxyapatite nano‐pillars on TI‐6Al‐4V: Enhancements in cell spreading and proliferation during cell/surface integration

Hydroxyapatite nano‐pillars on TI‐6Al‐4V: Enhancements in cell spreading and proliferation during cell/surface integration

Synthesis Factors Dependence of Magnetic Properties of CoFe2O4 and CoFe2-xGdxO4 Semicrystalline Nanoparticles with desired Morphology through Hydrothermal Procedure

Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation

Contact Info

Product

Resources

About