Enhanced permeability of ferulic acid loaded nanoemulsion based gel through skin against UVA mediated oxidative stress

Harwansh, Ranjit K.; Mukherjee, Pulok K.; Bahadur, Shiv; Biswas, Rajarshi

doi:10.1016/j.lfs.2015.10.001

Cited by 76 publications

(33 citation statements)

References 33 publications

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“…Moreover, the polyphenol profile founded in the current work is in agreement with previous studies of Sousa et al (2008) with different species and varieties of brassica; Luthria & Pastor-Corrales (2006a), Xu & Chang (2008) and Joseph et al (2014) for different important, because not only shows that wastes from these crops have similar profile as the respective edible counterparts, but also shows that they have a higher content of polyphenols, enhancing their chance to be used for extraction of bioactive compounds, particularly those associated with important beneficial properties on human health. Polyphenols like caffeic acid, ferulic acid, sinapic acid, quercetin and kaempferol, highly present in the current samples, have been reported as having strong antioxidant, anti-inflammatory and antimicrobial activities (Marchese et al, 2014;Deng et al, 2015;Harwansh et al, 2015). Sato et al (2011), in an in vitro and in vivo study, found that chlorogenic and caffeic acids can play a protective against intestinal injuries caused by radical oxygen species (ROS).…”

Section: Resultsmentioning

confidence: 90%

“…Polyphenols like caffeic acid, ferulic acid, sinapic acid, quercetin and kaempferol, highly present in the current samples, have been reported as having strong antioxidant, anti-inflammatory and antimicrobial activities (Marchese et al, 2014;Deng et al, 2015;Harwansh et al, 2015). Polyphenols like caffeic acid, ferulic acid, sinapic acid, quercetin and kaempferol, highly present in the current samples, have been reported as having strong antioxidant, anti-inflammatory and antimicrobial activities (Marchese et al, 2014;Deng et al, 2015;Harwansh et al, 2015).…”

Section: Figurementioning

confidence: 85%

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Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Aires

Carvalho

Saavedra

2016

Int J of Food Sci Tech

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Summary The aim of this study was to evaluate the potential use of crop wastes (stems and leaves) from broccoli, beans and tomato to extract antioxidant polyphenols. Two different methods of extraction were performed: ultrasound (40 kHz) and conventional with 70 °C. In both methods, alkaline and acidic solvents were used. The polyphenol composition was assessed by HPLC‐DAD/UV‐VIS, and the 2,2‐diphenyl‐1‐picrylhydrazyl assay was used to measure the antioxidant activity. The results showed a significant variation of polyphenol composition and antioxidant activity with the type of sample, pH of solvent and extraction method. Also it was possible to observe that acidic methanol and 70 °C enables the extraction of significant amounts of phenolic acids and flavonoids. Based in our results, broccoli, green bean and tomato wastes can be used to extract antioxidant polyphenols, and the use of such wastes to extract polyphenols can be an opportunity to develop an environmental friendly management's systems creating incoming for producers and agro‐food sector.

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Section: Resultsmentioning

confidence: 90%

Section: Figurementioning

confidence: 85%

Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Aires

Carvalho

Saavedra

2016

Int J of Food Sci Tech

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“…90 ). The in vivo application of FA in the form of a nanogel significantly increased the level of SOD, GPx and CAT and reduced the MDA level in UVA-irradiated rat skin 91 .…”

Section: Ferulic Acidmentioning

confidence: 92%

Ultraviolet A protective potential of plant extracts and phytochemicals

Škařupová

Vostalová

Svobodová

2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

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“…Another study exhibited the development of ferulic acidloaded NG with improved penetrability and augmented antioxidant activity in rats for the treatment of oxidative stress. This NG exhibited excellent stability and sustained release of the drug with outstanding antioxidant activity which could be attributed to the increase solubility of the drug and augmented permeability from the NG [94].…”

Section: Treatment Of Oxidative Stressmentioning

confidence: 99%

Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

Sabir

Asad

Qindeel

et al. 2019

Journal of Nanomaterials

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Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels.

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Enhanced permeability of ferulic acid loaded nanoemulsion based gel through skin against UVA mediated oxidative stress

Cited by 76 publications

References 33 publications

Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Ultraviolet A protective potential of plant extracts and phytochemicals

Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

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