Enhanced peroxidase-like activity of MOF nanozymes by co-catalysis for colorimetric detection of cholesterol

Abstract

Metal-organic frameworks (MOF) has been widely used as nanozymes with a great development prospect due to its unique advantages. It is known that the current Fe-based or Cu-based MOF, etc.,...

Bimetallic Cu–Zn Zeolitic Imidazolate Frameworks as Peroxidase Mimics for the Detection of Hydrogen Peroxide: Electrochemical and Spectrophotometric Evaluation

“…Initially, Cu + formation is facilitated by a Fenton like reaction as shown below (eq ). Cu + centers are responsible for the reduction of H 2 O 2 (eq ), and Cu + centers are in turn oxidized to Cu 2+ , which then oxidizes TMB to TMB + and reduces back to Cu + ions (eq ; Scheme ). 2 Cu 2 + → 2 Cu + + 2 normale − .25em ( Fenton‐like reaction in presence of H 2 O 2 ) 2 Cu + + normalH 2 normalO 2 → 2 Cu 2 + + normalH 2 normalO TMB + Cu 2 + → TMB + + Cu + …”

“…Also, doping of MOFs with various metals can enhance the performance of Fenton or Fenton-like reactions and thus enhance the decomposition efficiency of H 2 O 2 . Molybdenum (Mo) was doped over a copper-2-methyimidazole (2-MI) MOF where the doping of Mo was proven to enhance the peroxidase mimicking activity of Cu-2-MI MOF . An Fe–Ni-based bimetallic MOF was found to have intrinsic peroxidase-like activity, and it was immobilized along with the glucose oxidase enzyme for glucose sensing .…”

“…Molybdenum (Mo) was doped over a copper-2-methyimidazole (2-MI) MOF where the doping of Mo was proven to enhance the peroxidase mimicking activity of Cu-2-MI MOF. 14 An Fe–Ni-based bimetallic MOF was found to have intrinsic peroxidase-like activity, and it was immobilized along with the glucose oxidase enzyme for glucose sensing. 15 Doping of copper to the ZIF-67 MOF was shown to enhance gas uptake capacity and reported to be utilized for organic dye degradation.…”

Accelerating the Phosphatase-like Activity of Uio-66-NH2 by Catalytically Inactive Metal Ions and Its Application for Improved Fluorescence Detection of Cardiac Troponin I

“…To date, several strategies have been proposed to improve the intrinsic catalytic activities of nanozymes, such as surface modification, heteroatom doping, size controlling, exogenous energy fields, and adding promotors. ,− Among them, modifying or doping nanozymes with metal ions is a reliable and universal strategy to obtain highly active nanozymes. For example, Fe 3+ , Cu 2+ , Ce 4+ , and Au 3+ have been used to modify or dope carbon-based or metal organic framework (MOF) nanozymes to enhance their peroxidase-like or oxidase-like activities. − Zr 4+ and Ce 4+ have been applied to modify catalytically inactive nanomaterials for obtaining catalytically active nanozymes with high phosphatase-like activity. , It is worth noting that the mentioned metal ions themselves possess enzyme-like activities.…”

Breaking through the pH Limitation of Fe1–xS Nanozymes Using Component-Modulated Coupled Nanoclay

“…Disease markers are a kind of indicator that can objectively reflect the normal physiological condition and the development of the disease . In recent years, due to the advantages of low cost, high sensitivity, accuracy, and multifunctionality, , colorimetric methods based on nanozymes (i.e., nanomaterials with enzymatic properties) have gradually become a research hotspot in the field of disease marker detection, including xanthine, glucose, cholesterol, and lactic acid . However, nanozymes (especially metal sulfide nanozymes) exhibit high catalytic activity only under acidic conditions, resulting in low detection sensitivity.…”