Enhanced Photodynamic inactivation of Staphylococcus Aureus with Schiff base substituted Zinc phthalocyanines through conjugation to silver nanoparticles

Şen, Pınar; Nyokong, Tebello

doi:10.1016/j.molstruc.2021.130012

Cited by 15 publications

(17 citation statements)

References 45 publications

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“…Several studies on the ability of nanoparticles to enhance antibacterial activities have also been reported. Several nanocojugates, i.e., Schiff base complexes with zinc conjugated to silver nanoparticles, showed excellent antimicrobial activity against S. aureus [86]. A recent work by Minhaz et al (2020) [87] compared the activity of an SB (53) and silver nanoparticles of this compound (53-AgNPs), studied as nanoprobes.…”

Section: Nanoparticles Of Schiff Basesmentioning

confidence: 99%

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

et al. 2022

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Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic and organic chemistry. They are used as dyes, catalysts, polymer stabilizers, luminescence chemosensors, catalyzers in the fixation of CO2 biolubricant additives and have been suggested for solar energy applications as well. Further, a wide range of pharmacological and biological applications, such as antimalarial, antiproliferative, analgesic, anti-inflammatory, antiviral, antipyretic, antibacterial and antifungal uses, emphasize the need for SB synthesis. Several SBs conjugated with chitosan have been studied in order to enhance the antibacterial activity of chitosan. Moreover, the use of the nanoparticles of SBs may improve their antimicrobial effects. Herein, we provide an analytical overview of the antibacterial and antifungal properties of SBs and chitosan-based SBs as well as SBs-functionalized nanoparticles. The most relevant and recent literature was reviewed for this purpose.

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Section: Nanoparticles Of Schiff Basesmentioning

confidence: 99%

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

et al. 2022

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“…Moreover, gold NPs display biocompatibility, low toxicity, and immunogenicity, almost chemical inertness (distinctly from their inherent catalytic properties), while silver nanomaterials present intrinsic antimicrobial activity against a broad spectrum of microorganisms and related MDR infections (e.g., towards Gram(−) and Gram(+) mature biofilms of MRSA), and disruption of biofilm formations while being safe for mammalian cells [124][125][126].Ultimately, both Au and Ag NPs share nano features specific to noble metal systems, i.e., localized surface plasmon resonance (LSPR, arising from their resonant oscillation of their free electrons upon light exposure) and resonance energy transfer (RET), with subsequent optical and photothermal properties of enhancing appositeness in aPDT applications and PDI efficacy (e.g., ROS production) [127][128][129]. For the most part, Au and Ag NPs of various shapes (e.g., spheres, rods, cubes) are combined with organic PS molecules such as RB and MB [128][129][130][131][132][133][134][135][136], but also with metallated PSs such as ruthenium complexes, metallophthalocyanines, and metalloporphyrins [108,137,138]; the corresponding PS nanovehicles can also be labeled as "conjugates" but they strictly differ from the "mixtures" involving metal NPs and PS molecules [139]. Other noble metal NPs, viz., platinum, have also been employed in aPDT applications due to their multitarget action to inactivate microbes, although to a lower degree up to now owing to synthetic limitations [27,140].…”

Section: Metal Npsmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

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“…Due to these structural properties, it is used in many fields such as non‐linear optics, [4] pigments, [5] solar cells, [6–7] catalyst, [8–9] gas sensors, [10] liquid crystal [11] . In addition, it continues to be the subject of intense research for medical purposes such as antioxidant, antimicrobial, pharmacology, photosensitizer for photodynamic therapy [12–14] . Fluorescence properties and singlet oxygen production capacity are the most sought‐after properties of compounds, especially for photodynamic therapy.…”

Section: Introductionmentioning

confidence: 99%

“…[11] In addition, it continues to be the subject of intense research for medical purposes such as antioxidant, antimicrobial, pharmacology, photosensitizer for photodynamic therapy. [12][13][14] Fluorescence properties and singlet oxygen production capacity are the most sought-after properties of compounds, especially for photodynamic therapy. For this reason, in this study, the synthesis of axial phthalocyanines known for their fluorescent properties was aimed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Axial Bis(benzo[d][1,3]dioxol‐5‐ylmethoxy)phthalocyaninato Silicon (IV): Photophysical and Photochemical Properties and Docking Studies on DNA‐SiPc Interactions

2022

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The synthesis of an axial phthalocyanine compound by the reaction of piperonyl alcohol and SiPcCl2 has been reported. Its structure was characterized by compound 1HNMR,13CNMR, Mass, FTIR and UV visible spectroscopy. Photophysical and photochemical properties of the compound were investigated by fluorescence spectroscopy. The photosensitizer performance of the compound was determined. In addition, with the quantum chemical study, the HOMO ‐ LUMO band gap and the optimized structure of the compound were investigated with two basic sets of the TD‐DFT B3LYP method. The band gap (ΔE) was found to be in the range of 0.6–0.7 eV, and it was determined that the compound would require low energy in the chemotherapeutic interaction with light and in its stimulation. As a chemotherapy drug candidate, its adhesion to protein and DNA structure has been evaluated as in‐silico. In this context, the potential binding and interaction aspects of the new chemotherapeutically effective phthalocyanine compound with two kinds of homo sapiens protein‐DNA complexes were investigated by molecular docking approach. It bonded with the phthalocyanine compound in both crystal structures. A docking score of 6.315 kcal/mol was obtained in the 6DIA encoded DNA polymerase beta substrate complex.

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Enhanced Photodynamic inactivation of Staphylococcus Aureus with Schiff base substituted Zinc phthalocyanines through conjugation to silver nanoparticles

Cited by 15 publications

References 45 publications

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Synthesis of Axial Bis(benzo[d][1,3]dioxol‐5‐ylmethoxy)phthalocyaninato Silicon (IV): Photophysical and Photochemical Properties and Docking Studies on DNA‐SiPc Interactions

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