Enhanced Photodynamic Therapy

Li, Buhong; Lin, Li

doi:10.1002/9783527823550.ch6

Biomedical Photonic Technologies 2023

DOI: 10.1002/9783527823550.ch6

|View full text |Cite

Enhanced Photodynamic Therapy

Buhong Li¹,

Li Lin²

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate

Chen,

Shen,

Lin

et al. 2024

J. Innov. Opt. Health Sci.

View full text Add to dashboard Cite

Photodynamic therapy (PDT) has been increasingly used in the clinical treatment of neoplastic, inflammatory and infectious skin diseases. However, the generation of reactive oxygen species (ROS) may induce undesired side effects in normal tissue surrounding the treatment lesion, which is a big challenge for the clinical application of PDT. To date, (–)-Epigallocatechin gallate (EGCG) has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative damage. This study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether (Hemoporfin)-mediated PDT. The quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be [Formula: see text] M−1S−1 and [Formula: see text] M−1S−1, respectively. The vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel, suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with EGCG. This study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2, and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT.

show abstract

Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate

Chen,

Shen,

Lin

et al. 2024

J. Innov. Opt. Health Sci.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Enhanced Photodynamic Therapy

Cited by 1 publication

References 81 publications

Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate

Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate

Contact Info

Product

Resources

About