Enhanced Photodynamic Therapy: A Review of Combined Energy Sources

Rodrigues, José Guilherme Lança; Correia, J. H.

doi:10.3390/cells11243995

Cited by 31 publications

(41 citation statements)

References 125 publications

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“…According to numerous studies of photochemical reactions include a direct interaction of excited molecules with the help of photoirradiation the PS on the substrate and forming transient radicals that react with oxygen [7]. Interaction initiates a complex cascade of free radicals, such as singlet oxygen, hydroxyl radical, hydrogen peroxide and superoxide anion radical, causing the development of oxidative stress syndrome [11]. As a result, PDT effectively induced tumor-cell apoptosis, autophagy and necrosis, and tumor destruction [12,13].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Photodynamic Therapy with Chlorine-Based Photosensitizer in the Treatment of Basal Cell Carcinomas

Artsemyeva¹,

Tzerkovsky²

2023

J. Anal. Oncol.

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The aim of this study is to evaluate a safety and antitumor efficacy of photodynamic therapy (PDT) with chlorine-based photosensitizer (PS) for treatment patients with basal cell skin carcinomas (BCC). Material and Methods: The work was performed on the basis of the Department of hyperthermia and photodynamic therapy. The object of the study were 172 patients with a verified diagnosis of BCC (T1N0M0, I stage), who received treatment from 2007 to 2022. PS «Photolon» (RUE «Belmedpreparaty», Republic of Belarus) was administrated intravenously at a dose of 2.0-2.5 mg/kg. The session of PDT was performed 2.5-3 h after intravenous injection of PS using semiconductor lasers (λ=660±5 nm) with exposure doses 50-250 J/cm² and power density – 0.15-0.5 W/cm². Frequency and severity of side effects after treatment session was assessed based on the criteria CTCAE (Version 4.03; 2010). The antitumor efficacy was evaluated 3 months after treatment. Clinical outcome was evaluated visually and morphologically by cytological or histopathological examination. Performance criteria were as follows (according to WHO, 1979). Results: The phenomenon of skin phototoxicity due to violation of the light regime (hyperemia, burning, slight swelling of the soft tissues of the face; CTCAE, I-II grades) was registered in 5.8% of cases (n=10). Serious adverse reactions (anaphylactic shock, Quincke's edema, severe pain syndrome) after the administration of PS and photoirradiation were not identified. Complete and partial regressions of tumors was observed in 93.0% and 4.7% of patients, respectively. The objective answer was 97.7%. The frequency of local relapses of the disease 1, 2, 3, 4 and 5 years after PDT was 3.1%, 3.1%, 4.6%, 4.6% and 6.9%, respectively. Сonclusion: PDT is a well-tolerated and highly effective therapeutic option in patients with BCC.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Photodynamic Therapy with Chlorine-Based Photosensitizer in the Treatment of Basal Cell Carcinomas

Artsemyeva¹,

Tzerkovsky²

2023

J. Anal. Oncol.

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“…While photons in the range of 630-800 nm are effective for irradiation of photosensitized tissues, another report [8] suggested use of microwaves, X-rays, ultrasound and electric and magnetic fields to elicit phototoxicity. The authors suggest Cerenkov radiation as a possibility but then point out that the fluence rates from this source are insufficient to be effective.…”

Section: Matters Arisingmentioning

confidence: 99%

Adventures in Photodynamic Therapy: Location, Location, Location

Kessel

2023

Photochem & Photobiology

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“…Gastric cancer (GC) stands as the fifth most frequently diagnosed cancer, ranking as the fourth leading cause of all cancer-related light excitation for PDT. [9][10][11] One such approach involves the use of IR780, a recently developed NIR heptamethine cyanine dye, employed for both PDT and photothermal therapy (PTT). IR780 has emerged as a promising nano-agent for tumor therapies due to its higher optical stability and lower tissue autofluorescence compared to the widely used ICG (Indocyanine Green), [12] and has therefore become a cancer imaging probe and a targeted therapeutic tool for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Photodynamic Therapy Synergizing with Inhibition of Tumor Neutrophil Ferroptosis Boosts Anti‐PD‐1 Therapy of Gastric Cancer

Zhu,

Zheng,

Wang

et al. 2024

Advanced Science

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For tumor treatment, the ultimate goal in tumor therapy is to eliminate the primary tumor, manage potential metastases, and trigger an antitumor immune response, resulting in the complete clearance of all malignant cells. Tumor microenvironment (TME) refers to the local biological environment of solid tumors and has increasingly become an attractive target for cancer therapy. Neutrophils within TME of gastric cancer (GC) spontaneously undergo ferroptosis, and this process releases oxidized lipids that limit T cell activity. Enhanced photodynamic therapy (PDT) mediated by di‐iodinated IR780 (Icy7) significantly increases the production of reactive oxygen species (ROS). Meanwhile, neutrophil ferroptosis can be triggered by increased ROS generation in the TME. In this study, a liposome encapsulating both ferroptosis inhibitor Liproxstatin‐1 and modified photosensitizer Icy7, denoted LLI, significantly inhibits tumor growth of GC. LLI internalizes into MFC cells to generate ROS causing immunogenic cell death (ICD). Simultaneously, liposome‐deliver Liproxstatin‐1 effectively inhibits the ferroptosis of tumor neutrophils. LLI‐based immunogenic PDT and neutrophil‐targeting immunotherapy synergistically boost the anti‐PD‐1 treatment to elicit potent TME and systemic antitumor immune response with abscopal effects. In conclusion, LLI holds great potential for GC immunotherapy.

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Enhanced Photodynamic Therapy: A Review of Combined Energy Sources

Cited by 31 publications

References 125 publications

Efficacy of Photodynamic Therapy with Chlorine-Based Photosensitizer in the Treatment of Basal Cell Carcinomas

Efficacy of Photodynamic Therapy with Chlorine-Based Photosensitizer in the Treatment of Basal Cell Carcinomas

Adventures in Photodynamic Therapy: Location, Location, Location

Enhanced Photodynamic Therapy Synergizing with Inhibition of Tumor Neutrophil Ferroptosis Boosts Anti‐PD‐1 Therapy of Gastric Cancer

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