Enhanced platelet-derived microparticle formation is associated with carotid atherosclerosis in convalescent stroke patients

Łukasik, Maria; Różalski, Marcin; Luzak, Bogusława; Michalak, Michał; Ambrosius, Wojciech; Watała, Cezary; Kozubski, Wojciech

doi:10.3109/09537104.2011.654292

Cited by 55 publications

(42 citation statements)

References 32 publications

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“…In addition, circulating pMVs have been reported to reflect the size of myocardium at risk in patients with ST-elevation myocardial infarction (Jung et al, 2012) and correlated with the presence of atherothrombotic lesions in carotid plaques (Lukasik et al, 2013), intracranial atherosclerotic lesions (Kuriyama et al, 2010), early stage of coronary artery calcification in menopausal women (Jayachandran et al, 2008), cerebrovascular disease (Chiva-Blanch et al, 2016b) and peripheral arterial disease (van der Zee et al, 2006). Stenting in stable coronary atherosclerotic lesions is associated with a substantial release of pMVs (Horn et al, 2015).…”

Section: Platelet-derived Microvesicles and Cardiovascular Diseasementioning

confidence: 99%

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Suades²,

et al. 2016

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Reports in the last decade have suggested that the role of platelets in atherosclerosis and its thrombotic complications may be mediated, in part, by local secretion of platelet-derived microvesicles (pMVs), small cell blebs released during the platelet activation process. MVs are the most abundant cell-derived microvesicle subtype in the circulation. High concentrations of circulating MVs have been reported in patients with atherosclerosis, acute vascular syndromes, and/or diabetes mellitus, suggesting a potential correlation between the quantity of microvesicles and the clinical severity of the atherosclerotic disease. pMVs are considered to be biomarkers of disease but new information indicates that pMVs are also involved in signaling functions. pMVs evoke or promote haemostatic and inflammatory responses, neovascularization, cell survival, and apoptosis, processes involved in the pathophysiology of cardiovascular disease. This review is focused on the complex cross-talk between platelet-derived microvesicles, inflammatory cells and vascular elements and their relevance in the development of the atherosclerotic disease and its clinical outcomes, providing an updated state-of-the art of pMV involvement in atherothrombosis and pMV potential use as therapeutic agent influencing cardiovascular biomedicine in the future.

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Section: Platelet-derived Microvesicles and Cardiovascular Diseasementioning

confidence: 99%

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Suades²,

et al. 2016

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“…Despite technical challenges and variability in methods to quantify microvesicles (29), there is considerable clinical research interest in quantification of circulating microvesicles. Elevated platelet-derived microvesicles have been demonstrated in the circulation of patients with a variety of thrombotic and inflammatory disorders (130, 144, 148, 149, 190). Release of microvesicles is another mechanism by which platelets contribute to immune responses; as mentioned earlier, platelets were shown to release IL-1β-enriched microvesicles following stimulation by bacterial (27).…”

Section: Platelets As Immune Cellsmentioning

confidence: 99%

Platelets and Their Interactions with Other Immune Cells

Lam

Vijayan

Rumbaut

2015

Comprehensive Physiology

130

119

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Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This manuscript reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions.

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“…There is growing evidence for PMP playing important roles in atherosclerosis (Tan and Lip, 2005). In healthy subjects, low numbers of PMPs circulating in the blood exert only minor effects like phospatidylserine catalyzed generation of negligible amounts of thrombin (Rautou et al, 2011), but upon activation PMP abundance in the blood rises, as suggested by ex vivo activation with TRAP and ADP of platelets from convalescent stroke patients (Lukasik et al, 2013). PMPs were identified as transcellular delivery systems for chemokines such as CCL5 promoting monocyte recruitment and atherosclerosis (Mause et al, 2005).…”

Section: Platelet-derived Microparticles In Atherosclerosismentioning

confidence: 99%

Platelets and their chemokines in atherosclerosisâ€”clinical applications

2014

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The concept of platelets as important players in the process of atherogenesis has become increasingly accepted due to accumulating experimental and clinical evidence. Despite the progress in understanding the molecular details of atherosclerosis, particularly by using animal models, the inflammatory and thrombotic roles of activated platelet s especially in the human system remain difficult to dissect, as often only the complications of atherosclerosis, i.e., stroke and myocardial infarction are definable but not the plaque burden. Platelet indices including platelet count and mean platelet volume (MPV) and soluble mediators released by activated platelets are associated with atherosclerosis. The chemokine CXCL4 has multiple atherogenic activities, e.g., altering the differentiation of T cells and macrophages by inhibiting neutrophil and monocyte apoptosis and by increasing the uptake of oxLDL and synergizing with CCL5. CCL5 is released and deposited on endothelium by activated platelets thereby triggering atherogenic monocyte recruitment, which can be attenuated by blocking the corresponding chemokine receptor CCR5. Atheroprotective and plaque stabilizing properties are attributed to CXCL12, which plays an important role in regenerative processes by attracting progenitor cells. Its release from luminal attached platelets accelerates endothelial healing after injury. Platelet surface molecules GPIIb/IIIa, GP1bα, P-selectin, JAM-A and the CD40/CD40L dyade are crucially involved in the interaction with endothelial cells, leukocytes and matrix molecules affecting atherogenesis. Beyond the effects on the arterial inflammatory infiltrate, platelets affect cholesterol metabolism by binding, modifying and endocytosing LDL particles via their scavenger receptors and contribute to the formation of lipid laden macrophages. Current medical therapies for the prevention of atherosclerotic therapies enable the elucidation of mechanisms linking platelets to inflammation and atherosclerosis.

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Enhanced platelet-derived microparticle formation is associated with carotid atherosclerosis in convalescent stroke patients

Cited by 55 publications

References 32 publications

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Platelets and Their Interactions with Other Immune Cells

Platelets and their chemokines in atherosclerosisâ€”clinical applications

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