Enhanced production and action of cyclic ADP–ribose during oxidative stress in small bovine coronary arterial smooth muscle

CD38 Mediates Angiotensin II–Induced Intracellular Ca2+ Release in Rat Pulmonary Arterial Smooth Muscle Cells

“…RyR1 and RyR2 are associated mainly with SR in the subsarcolemmal region, whereas RyR3 is localized predominantly in the perinuclear SR (23,40 There is substantial evidence suggesting that Ang II enhances ROS production through activation of NOX, contributing to Ca 21 response in VSMCs (17). Several studies have shown that CD38 activity is regulated by redox state and oxidative stress (19,20,22,27,43). However, the mechanism of Ang II-induced CD38 activation in PASMCs has not been established.…”

“…Evidence from other studies suggests that Ang II and ET-1 can also activate NADPH oxidases (NOXs) to increase the production of reactive oxygen species (ROS) in VSMCs (17). Several studies showed that ROS production is associated with CD38 activation (18)(19)(20). These observations suggest that CD38 may play an important role in the regulation of agonist-induced vascular responses.…”

Local production of O2− by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation

“…In these experiments, we used M 1 agonist, oxotremorine (Oxo), to stimulate O 2 .− production via NAD(P)H oxidase in CAMs. The reason for the use of this M 1 agonist, Oxo, is due to its strong action inducing O 2 .− production and vasoconstriction in denuded bovine coronary arteries [7,30]. In particular, previous studies have shown that bovine coronary arteries are insensitive to classical vasoconstrictors such as angiotensin II, norepinephrine, and vasopressin [7,[31][32][33] and therefore the vasoconstrictor action of this M 1 agonist is unique in studying the mechanism of bovine coronary vasoconstriction.…”

“…In particular, previous studies have shown that bovine coronary arteries are insensitive to classical vasoconstrictors such as angiotensin II, norepinephrine, and vasopressin [7,[31][32][33] and therefore the vasoconstrictor action of this M 1 agonist is unique in studying the mechanism of bovine coronary vasoconstriction. This compound-induced vasoconstriction was often found to be accompanied by O 2 .− production, and the latter may further enhance or amplify the vasoconstriction in these arteries [3,30,34]. In addition, many studies have demonstrated that M 1 receptor activation produces vasoconstriction primarily through cADPRRyR Ca 2+ signaling pathway in coronary arteries [13,35].…”

“…In addition, many studies have demonstrated that M 1 receptor activation produces vasoconstriction primarily through cADPRRyR Ca 2+ signaling pathway in coronary arteries [13,35]. Based on these findings, it is proposed that M 1 agonist is a unique tool compound for studies of Ca 2+ and redox signaling and their interactions in CAMs [30,36].…”