Enhanced properties of nickel–silver codoped hydroxyapatite for bone tissue engineering: Synthesis, characterization, and biocompatibility evaluation

Sivakumar, Ponnurengam Malliappan; Yetisgin, Abuzer Alp; Sahin, Sevilay Burcu; Demir, Ebru; Cetinel, Sibel

doi:10.1016/j.envres.2023.117131

Environmental Research

2023

DOI: 10.1016/j.envres.2023.117131

|View full text |Cite

Enhanced properties of nickel–silver codoped hydroxyapatite for bone tissue engineering: Synthesis, characterization, and biocompatibility evaluation

Ponnurengam Malliappan Sivakumar,

Abuzer Alp Yetisgin,

Sevilay Burcu Sahin

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cationic substitution effects in phosphate-based bioceramics - A way towards superior bioproperties

Lukaviciute,

Ganceviciene,

Tsuru

et al. 2024

Ceramics International

View full text Add to dashboard Cite

Cationic substitution effects in phosphate-based bioceramics - A way towards superior bioproperties

Lukaviciute,

Ganceviciene,

Tsuru

et al. 2024

Ceramics International

View full text Add to dashboard Cite

Eco-friendly nanotechnology in rheumatoid arthritis: ANFIS-XGBoost enhanced layered nanomaterials

Zhang,

Ye,

et al. 2024

Environmental Research

View full text Add to dashboard Cite

Internalized Hydroxyapatite Nanoparticles Conjugated with a Modified Form of Curcumin Functionalized with Folic Acid Promote Bone Tumor Cell Necrosis

Rodrigues,

Marinho,

Arantes Fernandes Vieira

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Osteosarcoma (OS) is a common aggressive bone tumor that affects both young adults and children. The prognosis for this type of cancer remains poor due to high lung metastasis rates and radiotherapy resistance. Consequently, the development of innovative strategies to prevent this type of cancer recurrence and metastasis is crucial. This study explored an OS treatment using a modified form of curcumin (CMAP) with hydroxyapatite (CMAP-HA) functionalized with folic acid (CMAP-HAF). The samples were characterized by Fourier transform infrared spectroscopy (FTIR), CHN elemental analysis, ζ-potential, and transmission electron microscopy (TEM). The results showed the successful incorporation of folic acid (FA) into the nanostructure, resulting in cytotoxic effects on osteosarcoma cells (U2OS) and adult human dermal fibroblasts (HDFa). CMAP-HAF treatment decreased cyclin E expression by 16.8 ± 2.3%. Furthermore, CMAP-HAF was internalized by 99.6% of U2OS cells, compromising plasma membrane integrity, causing necrosis, affecting cell migration and cloning formation. These findings suggest that CMAP-HAF is a promising therapeutic agent for OS treatment and offers an innovative approach to improve patient outcomes.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Enhanced properties of nickel–silver codoped hydroxyapatite for bone tissue engineering: Synthesis, characterization, and biocompatibility evaluation

Cited by 5 publications

References 56 publications

Cationic substitution effects in phosphate-based bioceramics - A way towards superior bioproperties

Cationic substitution effects in phosphate-based bioceramics - A way towards superior bioproperties

Eco-friendly nanotechnology in rheumatoid arthritis: ANFIS-XGBoost enhanced layered nanomaterials

Internalized Hydroxyapatite Nanoparticles Conjugated with a Modified Form of Curcumin Functionalized with Folic Acid Promote Bone Tumor Cell Necrosis

Contact Info

Product

Resources

About