Enhanced protein synthesis in Triatoma infestans treated with DDT

Agosín, Manuel R.; Aravena, Luisa; Neghme, A

doi:10.1016/0014-4894(65)90053-6

Cited by 29 publications

(6 citation statements)

References 9 publications

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“…However, MORELLO (1964) found a slightly higher rate of DDT detoxicafion in vivo in Triatoma in/estans after treatment with 3-methylcholanthrene, but rightly remarks that this is not necessarily due to the induction of microsomal activity. AGOSlN et al (1965AGOSlN et al ( , 1966 found evidence for an irffluence o~ DDT on protein synthesis in Triatoma infestans and Musca domestica. It remains to be seen however whether these observations should be regarded as induction in the sense of a stimulation of a specific detoxicatio~a system, in particular since curious differences occurred between different stages (Triatoma) and strains (Musca).…”

Section: Discussionmentioning

confidence: 99%

DDT Resistance in the Housefly Caused by Microsomal Degradation

Oppenoorth¹,

Houx²

1968

Entomologia Exp Applicata

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In vitro microsomal detoxication of DDT was studied in five strains of houseflies. One of these, Fc, is resistant to DDT and diazinon, and this resistance can be overcome by sesamex. Microsomes of this strain degraded DDT at a rate of 0.5 μg per fly per hour to at least four products of higher polarity. Resistance in this strain is due to a gene on the 3rd chromosome, which we have called DDT‐md (microsomal detoxication). Evidence is presented that some of the products from DDT are produced in more than one step, and that primary and secondary reactions occur in microsomes of strain Fc only and are CO sensitive. In the other strains tested there was only a much lower rate of detoxication. No evidence was found in Fc flies of an increased detoxication by microsomal induction with DDT. Zusammenfassung DURCH MIKROSOMALEN ABBAU HERVORGERUFENE DDT‐RESISTENZ BEI DER STUBENFLIEGE Entgiftung von DDT durch Mikrosomen in vitro wurde bei 5 Stubenfliegen‐Stämmen studiert. Einer von ihnen, Fc, ist resistent gegen DDT und Diazinon; diese Resistenz kann durch Sesamex überwunden werden. Mikrosomen dieses Stammes bauten DDT mit einer Rate von 0,5 mg pro Fliege und Stunde zu wenigstens 4 Produkten höherer Polarität ab. Die Resistenz beruht in diesem Stamme auf einem Gen im dritten Chromosom, welches wir DDT‐md (microsomal detoxication) genannt haben. Es wird wahrscheinlich gemacht, daß einige der Produkte aus DDT in mehr als einem Schritt erzeugt werden und daß primäre und sekundäre Reaktionen nur in Mikrosomen des Fc‐Stammes auftreten und CO‐empfindlich sind. In anderen geprüften Stämmen ergab sich nur eine geringere Entgiftungsratc. In Fc‐Fliegen war kein Nachweis für eine verstärkte Entgiftung durch mikrosomale Induktion mit DDT zu erbringen.

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Section: Discussionmentioning

confidence: 99%

DDT Resistance in the Housefly Caused by Microsomal Degradation

Oppenoorth¹,

Houx²

1968

Entomologia Exp Applicata

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“…Protein and FAA were not involved in the mobilization of carbohydrates and lipids in treated beetles except for permethrin treatments. Agosin et al [36] reported enhanced protein synthesis in Triatoma infestans treated with another cholorinated insecticide, DDT. Kulkarni and Mehrotra 1371, however, concluded that dieldrin and sumithion did not alter amino acid nitrogen and proline titers during the initial stages of poisoning.…”

Section: Synthetic Pyrethroids Have Attracted Considerable Attention mentioning

confidence: 99%

Permethrin‐ and malathion‐induced macromolecular abnormalities in adult Tribolium castaneum (herbst)

Saleem

Shakoori

1987

Arch Insect Biochem Physiol

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In Tribolium castaneum adults, sublethal doses of 1 and 2 ppm permethrin and 300 ppm malathion led to significant changes in amylase, trehalase, acid phosphatase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and isocitrate dehydrogenase activities. Malathion at 150 ppm did not affect phosphatases and lactate dehydrogenase. Both malathion and permethrin significantly increased cholinesterase activity. Mixing of the two insecticides resulted in antagonistic action with reference to various enzymatic activities. Glucose and glycogen contents were at first mobilized for energy supply under insecticidal stress conditions followed by lipid and cholesterol. Soluble protein, total protein, free amino acids, and urea contents remained unaltered under all experimental conditions.

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“…The present results are also in agreement with findings of above workers. Synthetic insecticides have also been shown to decrease the total protein level in insects by inhibiting amino acid incorporation into protein causing adverse effect on protein biosynthesis 25,23,1 .…”

Section: Resultsmentioning

confidence: 99%