Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma

He, Zhonglei; Charleton, Clara; Devine, Robert; Kelada, Mark; Walsh, John M.D.; Conway, Gillian E; Gunes, Sebnem; Mondala, Julie Rose Mae; Tian, Furong; Tiwari, Brijesh K.; Kinsella, Gemma K.; Malone, Renee; O’Shea, Denis; Devereux, Michael; Wang, Wenxin; Cullen, Patrick J.; Stephens, John C.; Curtin, James F.

doi:10.1016/j.ejmech.2021.113736

Cited by 7 publications

(1 citation statement)

References 56 publications

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“…Glial cells play a significant supportive role to the neuron cells in the brain and perform important physiological functions. Glioblastoma multiforme (GBM) accounts for 60% of brain tumors, and the median reported survival of GBM patients after its first diagnosis is, unfortunately, only about 16 months due to the unstoppable proliferation of glioma cells, poor diagnosis, disease prognosis, and a high-grade metastasis [ 1 ]. Glioma patients are treated with surgery to remove the tumor or the tumor-carrying site, followed by chemotherapy and radiation therapy to slow or stop the tumor growth [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel on a Smart Nanomaterial Interface to Carry Therapeutics for Digitalized Glioma Treatment

Zhao

Javed

Tian

et al. 2022

Gels

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Glioma is considered the primary brain tumor to cause brain illnesses, and it is difficult to treat and shows resistance to various routine therapeutics. The most common treatments to cure glioma are the surgical removal of tumors followed by adjuvant chemotherapy and radiation therapy. The latest biocompatible interfaces have been incorporated into therapeutic modalities such as the targeted delivery of drugs using hydrogels to treat and manage brain glioma. This review illustrates the applications of the multimodal hydrogel as the carrier of therapeutics, gene therapy, therapeutic tactics, and glioma devices. The scientific articles were retrieved from 2019 to 2022 on Google Scholar and the Scopus database and screened to determine whether they were suitable for review. The 20 articles that fit the study are summarized in this review. These studies indicated that the sizes of the hydrogel range from 28 nm to 500 nm. There are 16 out of 20 articles that also explain the post-surgical application of hydrogels, and 13 out of 20 articles are employed in 3D culture and other structural manifestations of hydrogels. The pros of the hydrogel include the quick formulation for a sufficient filling of irregular damage sites, solubilizing hydrophobic drugs, continuously slowing drug release, provision of a 3D cell growth environment, improving efficacy, targetability of soluble biomolecules, increasing patient compliance, and decreased side effects. The cons of the hydrogel include difficult real-time monitoring, genetic manipulations, the cumbersome synchronized release of components, and lack of safety data. The prospects of the hydrogel may include the development of electronic hydrogel sensors that can be used to enhance guidance for the precise targeting patterns using patient-specific pathological idiosyncrasies. This technology has the potential to revolutionize the precision medicine approaches that would aid in the early detection and management of solid brain tumors.

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Section: Introductionmentioning

confidence: 99%

Hydrogel on a Smart Nanomaterial Interface to Carry Therapeutics for Digitalized Glioma Treatment

Zhao

Javed

Tian

et al. 2022

Gels

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Nickel supported on magnetic biochar as a highly efficient and recyclable heterogeneous catalyst for the one‐pot synthesis of spirooxindole‐dihydropyridines

Dong

Wang

Zhang

et al. 2022

Applied Organom Chemis

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Magnetic materials show promising applications in heterogeneous catalysis because of their ease of separation and good reusability. The present work reports the design, synthesis, and characterization of a novel magnetic biochar supported nickel catalyst. Fourier infrared spectroscopy (FT‐IR), powder X‐ray diffraction technology (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and vibrating sample magnetometer (VSM) techniques were used for analyzing the prepared catalyst. The prepared catalyst exhibited excellent catalytic activity for synthesis of spirooxindole‐dihydropyridines derivatives by a one‐pot three‐component reaction of isatin, barbituric acid, and 6‐amino uracil or 1H‐pyrazol‐5‐amine. This new methodology demonstrated some important features, including high yields, lower loading of the catalyst, easy work‐up, and recyclability of the catalyst for a minimum of six times without an obvious decay of catalytic performance.

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Characteristics of Portable Air Floating-Electrode Dielectric-Barrier-Discharge Plasmas Used for Biomedicine

Zhao,

Chen

et al. 2023

Plasma Chem Plasma Process

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Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma

Cited by 7 publications

References 56 publications

Hydrogel on a Smart Nanomaterial Interface to Carry Therapeutics for Digitalized Glioma Treatment

Hydrogel on a Smart Nanomaterial Interface to Carry Therapeutics for Digitalized Glioma Treatment

Nickel supported on magnetic biochar as a highly efficient and recyclable heterogeneous catalyst for the one‐pot synthesis of spirooxindole‐dihydropyridines

Characteristics of Portable Air Floating-Electrode Dielectric-Barrier-Discharge Plasmas Used for Biomedicine

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