1991
DOI: 10.1002/mcs.1220030203
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Enhanced radial dispersion in open tubular column chromatography

Abstract: Abstract. Radial diffusion of solutes in the mobile phase limits the practical linear velocities that can be used to increase speed of analysis in conventional open tubular column chromatography. Several methods have been devised to enhance radial dispersion that do not depend only on molecular radial diffusion. In this review, the methods of enhancing dispersion found in the chromatographic literature are discussed. These methods include the use of deformed columns, and spinning band and static mixer columns.… Show more

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Cited by 22 publications
(7 citation statements)
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“…Particularly, the nonlinear macroscopic EOF dynamics (Figure ), relatively extended induced space charge regions (Figure ), flow instability (Figure ), and the resulting pore-scale dispersion (Figure ) constitute key differences. Thus, induced-charge electroosmosis can become a promising tool for process intensification, e.g., in electrodialysis (membrane transport) which is severely limited by stable CP, , or in miniaturized devices concerning the nonlinear pumping of bulk fluid and efficient mixing at low Re, i.e., Re < 1. , In separation science, the realization and control of chaotic instability and turbulent flow over defined temporal and spatial domains has been a challenging task for a long time. In this respect, nonlinear electrokinetics analyzed in this letter is a unique mechanism for reducing axial dispersion by faster lateral exchange of analytes beween flow velocity extremes during the long-distance transport through porous media employed, e.g., in electrochromatography. Future work needs to address the influence of the applied field and mobile phase ionic strengths, local hydrodynamics, morphology of the pore space, and surface physicochemical properties on the development and consequences of induced-charge electroosmosis in porous media.…”
mentioning
confidence: 99%
“…Particularly, the nonlinear macroscopic EOF dynamics (Figure ), relatively extended induced space charge regions (Figure ), flow instability (Figure ), and the resulting pore-scale dispersion (Figure ) constitute key differences. Thus, induced-charge electroosmosis can become a promising tool for process intensification, e.g., in electrodialysis (membrane transport) which is severely limited by stable CP, , or in miniaturized devices concerning the nonlinear pumping of bulk fluid and efficient mixing at low Re, i.e., Re < 1. , In separation science, the realization and control of chaotic instability and turbulent flow over defined temporal and spatial domains has been a challenging task for a long time. In this respect, nonlinear electrokinetics analyzed in this letter is a unique mechanism for reducing axial dispersion by faster lateral exchange of analytes beween flow velocity extremes during the long-distance transport through porous media employed, e.g., in electrochromatography. Future work needs to address the influence of the applied field and mobile phase ionic strengths, local hydrodynamics, morphology of the pore space, and surface physicochemical properties on the development and consequences of induced-charge electroosmosis in porous media.…”
mentioning
confidence: 99%
“…In conventional gas chromatography, used columns are tubes functionalized by a stationary phase having length ranging from 10 to 100 m. To obtain an excellent column, few parameters can be optimized: length, inner diameter, film thickness, and the coiling radius [37]. Theory of chromatography predicts an increase of efficiency, while the diameter of a capillary column decreases.…”
Section: Geometrymentioning
confidence: 99%
“…Such flow distribution is through electroosmotic flows (Ghosal, 2004 andZholkovskij, et al, 2004,), redox-magnetohydrodynamics (Anderson, et al, 2010, Weston, et al, 2012, and Sahore, et al, 2013, or the optimized geometry of the channel cross section under pressure driven flows (Dutta, et al, 2001, Ajdari, et al, 2006, and Parks, et al, 2007. Increasing apparent radial dispersion (Sumpter, et al, 1991) is another way for reducing axial dispersion. Utilizing turbulent flows is one of the methods for increasing radial dispersion.…”
Section: Columnmentioning
confidence: 99%