Enhanced recovery after surgery (ERAS) programs for esophagectomy protocol for a systematic review and meta-analysis

Abstract

Background:Esophageal cancer is one of the worst malignant digestive neoplasms with poor treatment outcomes. Esophagectomy plays an important role and offers a potential curable chance to these patients. However, esophagectomy with radical lymphadenectomy is known as one of the most invasive digestive surgeries which are associated with high morbidity and mortality. The enhanced recovery after surgery (ERAS) protocol is a patient-centered, surgeon-led system combining anesthesia, nursing, nutrition, and psychology, which is designed for reducing complications, promoting recovery, and improving treatment outcomes. This systematic review and meta-analysis is aiming at how beneficial, and to what extent ERAS really will be.Methods:A systematic literature search will be performed through January 2018 using MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and Google Scholar for relevant articles published in any language. Randomized controlled trials, prospective cohort studies, and propensity-matched comparative studies will be included. All meta-analyses will be performed using Review Manager software. The quality of the studies will be evaluated using the guidelines listed in the Cochrane Handbook. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements will be followed until the findings of the systematic review and meta-analysis are reported.Results:The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.Conclusion:Our study will draw an objective conclusion of the comparisons between ERAS and conventional care in aspects of perioperative outcomes and provide level I evidences for clinical decision makings.

Smoking and pulmonary complications: respiratory prehabilitation

“…The importance of perioperative management is highlighted because esophageal cancer is the ninth most commonly diagnosed and the sixth most common cause of cancer-related neoplasms with a high perioperative risk of death (1). The best treatment option for these patients is esophagectomy as a curative approach; however, this procedure with radical lymphadenectomy is known as one of the most invasive digestive operations (1,2).…”

Enhanced recovery after surgery (ERAS) pathway for primary hip and knee arthroplasty: study protocol for a randomized controlled trial

“…The concept of ERAS, or fast-track surgery, was introduced in 1997 by Dr. Henrik Kehlet [9], a gastrointestional surgeon who won 2014 Excellence in Research Award by the American Society of Anesthesiologists (ASA) for his outstanding contributions to anesthesiology by the creation of ERAS. A number of literatures, including clinical studies [10][11][12], reviews [6,13,14], and meta-analysis [4,15,16] demonstrated that compared with conventional treatment, implementation of ERAS protocol could be associated with reduced length of stay in hospital, decreased morbidity, attenuated stress, less in-hospital cost, and accelerated recovery in various types of surgery during perioperative period.…”

Enhanced recovery after surgery (ERAS) pathway for primary hip and knee arthroplasty: study protocol for a randomized controlled trial

“…The concept of ERAS, or fast-track surgery, was introduced in 1997 by Dr. Henrik Kehlet [11], a gastrointestional surgeon who won 2014 Excellence in Research Award by the American Society of Anesthesiologists (ASA) for his outstanding contributions to anesthesiology by the creation of ERAS. A number of literatures, including clinical studies [12][13][14], reviews [6,15,16], and meta-analysis [4,17,18] demonstrated that compared with conventional treatment, implementation of ERAS protocol could be associated with reduced length of stay in hospital, decreased morbidity, attenuated stress, less in-hospital cost, and accelerated recovery in various types of surgery during perioperative period.…”