2019
DOI: 10.1016/j.biomaterials.2018.11.009
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Enhanced repair of meniscal hoop structure injuries using an aligned electrospun nanofibrous scaffold combined with a mesenchymal stem cell-derived tissue engineered construct

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Cited by 61 publications
(59 citation statements)
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“…An increasing number of studies are supporting the idea that cell-based strategies effectively improve meniscus repair and regeneration 32 33. However, it is still not clear which cell type is most effective for meniscus repair 34 35.…”
Section: Discussionmentioning
confidence: 99%
“…An increasing number of studies are supporting the idea that cell-based strategies effectively improve meniscus repair and regeneration 32 33. However, it is still not clear which cell type is most effective for meniscus repair 34 35.…”
Section: Discussionmentioning
confidence: 99%
“…Electrospun nanofibers have found extensive applications in the energy, environment, and biomedical field [1]. In biomedical applications, adjusting the surface properties of the nanofibers (e.g., fiber orientation and patterned structure) is frequently employed to achieve specific cell adhesion and growth on fiber surfaces [9,10]. Favorable cell adhesion is the key to tissue regeneration [11], but cell adhesion could lead to serious undesirable consequences under certain circumstances, such as tendon adhesion [12], intestinal adhesion [13], and intrauterine adhesion [14].…”
Section: Introductionmentioning
confidence: 99%
“…MSCs seeded in nanofibrous meniscus scaffolds demonstrated fibrocartilage tissue growth that improved biomechanical properties at the knee and protected cartilage from degeneration in an animal model 68. Shimomura et al found similar results using a MSC-seeded nanofibrous scaffold constructed to match the meniscus circumferential fibre structure, and they demonstrated a significant decrease in meniscus extrusion following repair 71. Conversely, Hong et al 72 did not find evidence of tissue healing or regeneration with bone marrow stem cell matrix implantation in animal medial meniscus root tears.…”
Section: Bodymentioning
confidence: 92%