We investigate pairing and superconductivity in the attractive Hubbard model on the onedimensional sawtooth lattice. This is a periodic lattice with two sites per unit cell, which exhibits a flat band (FB) by fine-tuning the hopping rates. We first discuss the formation of pairs in vacuum, showing that there is a broad region of hopping rates values around the FB point, for which both the binding energy and the effective mass of the bound state are strongly affected even by weak interactions. Based on the DMRG method, we then address the ground-state properties of a system with equal spin populations as a function of the interaction strength and the hopping rates. We compare our results with those available for a linear chain, where the model is integrable by Bethe ansatz, and show that the multiband nature of the system substantially modifies the physics of the BCS-BEC crossover. The chemical potential of a system near the FB point remains always close to its zero-density limit predicted by the two-body physics. In contrast, the pairing gap exhibits a remarkably strong density dependence and, differently from the binding energy, it is no longer peaked at the FB point. We show that these results can be interpreted in terms of polarization screening effects, due to an anomalous attraction between pairs in the medium and single fermions. In particular, we find that three-body bound states (trimers) are allowed in the sawtooth lattice, in sharp contrast with the linear chain geometry.